摘要
Thelymphaticsystemhasanimportantdefensiveroleinthehumanbody.Themetastasisofmosttumorsinitiallyspreadsthroughthesurroundinglymphatictissueandeventuallyformslymphaticmetastatictumors;thetumorcellsmayeventransfertootherorganstoformothertypesoftumors.Clinically,lymphaticmetastatictumorsdeveloprapidly.Giventhelimitationsofsurgicalresectionandtheloweffectivenessofradiotherapyandchemotherapy,thetreatmentoflymphaticmetastatictumorsremainsagreatchallenge.Lymphnodemetastasismayleadtothefurtherspreadoftumorsandmaybepredictiveoftheendpointevent.Underthesecircumstances,novelandeffectivelymphatictargeteddrugdeliverysystemshavebeenexploredtoimprovethespecificityofanticancerdrugstotumorcellsinlymphnodes.Inthisreview,wesummarizetheprinciplesoflymphatictargeteddrugdeliveryanddiscussrecentadvancesinthedevelopmentoflymphatictargetedcarriers.
出版日期
2014年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
