摘要
AlportsyndromeisanX-linkedsyndromethatresultsinnephritis,renalfailure,sensorineuralhearingloss,andeyedeficits.Asaresultofsensorineuralhearingloss,theseindividualsarelikelytoexperiencedifficultiesintheareaofspeechandlanguage.Whilestudiesinthepasthaveexaminedthespeechandlanguagecharacteristicsofchildrenwithsyndromicsensorineuralhearingloss,toourknowledgetherearenopreviousstudiestohavedocumentedthespeechandlanguagecharacteristicsofthesechildrenonalong-termbasis.Thecurrentstudyaddressesthislimitationbyreportingspeech,language,hearing,andfunctionoftwinbrotherswithX-linkedAlportsyndromeacrossaseven-yearperiod.Informationwascollectedbyexaminingthemedicalrecordsoftheparticipantsaswellasthroughaverbalinterviewwiththeparticipants'guardian.Resultsrevealedthattheparticipants'hearingabilitiesgraduallydeterioratedovertheseven-yearperiodwhichaffectedtheirspeechandlanguagedevelopmentaswell.Thekidneyfunctiontestsrevealedsignificantpresenceofhematuria(bloodintheurine)aswellasproteinuria(proteinintheurine)suggestingchronickidneydysfunction.Thislongitudinalstudydemonstratesthefunctionalrelationshipbetweenthekidneysandthecochlea,althoughtheyappeartobeindependentofoneanother.AsindividualswithAlportsyndromeexhibitsystemiccomplications,interdisciplinarycollaborationisessentialamonghealthcareprovidersincludingaudiologists,speech-languagepathologists,nephrologists,andophthalmologisttopromoteevidence-basedpractice.
出版日期
2017年02月12日（中国期刊网平台首次上网日期，不代表论文的发表时间）
