摘要
4-Amino-5-(pyridin-3-yl)-4H-1,2,4-triazole-3-thiol1werecondensedwith2-bromo-1-(substitutedphenyl)ethanonetogivepyridinyltriazolothiadiazines2a～c,whichwerequaternarizedwithmethyliodideandoxidizedwith30%hydrogenperoxidetoaffordthecorrespondingmethylpyridiniumsalts3a～candpyridine-l-oxides4a～c,respectively.Thereductionofcompounds3and4withNaBH4inmethanolproducedthetargetcompounds1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryl-s-triazolothiadiazines5a～cand3-(1-hydroxyl-1,2,5,6-tetrahydropyridin-3-yl)-6-aryls-triazolothiadiazines6a～c,respectively.Theendotheliumvascularrelaxingactivityofthetargetcompoundswasscreened.
出版日期
2005年01月11日（中国期刊网平台首次上网日期，不代表论文的发表时间）
