简介：　　 [摘要 ] 目的 研究晚期结肠癌与直肠癌化疗近期有效率的差异。方法 共收集复发转移性大肠癌患者 194例，其中结肠癌患者 94例，直肠癌患者 100例，采用 χ2检验的方法对比分析两组患者经 4周期一线姑息性化疗后的疗效差异，以 P<0.05为标准。 结果 直肠癌患者化疗有效（ CR+PR） 38例（ 38.00%）。结肠癌患者中化疗有效（ CR+PR） 52例（ 55.32%）。两组患者化疗有效率差异有统计学意义（ P<0.05）。结论 晚期结肠癌患者姑息化疗近期有效率优于直肠癌组。  　　 [关键词 ] 晚期结肠癌；直肠癌；姑息化疗；差异  　 [Abstract] Objective To study the difference of short-term response rate between advanced colorectal cancer and rectal cancer. Methods a total of 194 patients with recurrent and metastatic colorectal cancer were collected, including 94 patients with colon cancer and 100 patients with rectal cancer. χ 2 test was used to compare and analyze the therapeutic effect of the two groups after four cycles of first-line palliative chemotherapy, with P < 0.05 as the standard. Results 38 patients (38.00%) had Cr + pr. Among the patients with colon cancer, 52 (55.32%) had effective chemotherapy (Cr + PR). There was significant difference in the effective rate of chemotherapy between the two groups (P < 0.05). Conclusion the short-term effective rate of palliative chemotherapy in patients with advanced colorectal cancer is better than that in patients with rectal cancer.