简介：摘要目的观察替吉奥联合草酸铂对比替吉奥单药治疗老年晚期胃癌的临床效果.方法回顾分析我院收治的８６例老年晚期胃癌患者,按照化疗方案分为两组,A组化疗方案为单药替吉奥口服,B组化疗方案为替吉奥联合草酸铂,治疗４周期后观察两组患者的一般情况、化疗副反应、近期有效率,并随访两组的一年生存率及总生存时间.结果４周期化疗后,A组KPS评分改善率与B组比较无统计学意义(P＞０．０５);A组近期有效率较B组低(３７．１％,６７．５％),比较有明显统计学差异(P＜０．０１);治疗过程中,A组发生Ⅱ~Ⅳ度白细胞、血小板下降及外周神经毒性人数较B组少,比较有统计学意义(P＜０．０５);两组一年生存率比较无统计学意义(P＞０．０５);Kaplan－Meier生存曲线提示B组较A组无明显生存优势(P＞０．０５).结论替吉奥联合草酸铂较单药替吉奥治疗老年晚期胃癌具有更高的近期有效率,但增加了化疗副反应,且并不能提高患者的一年生存率及总生存时间.关键词老年晚期;胃癌;替吉奥;草酸铂;总生存时间AbstractObjectiveTocomparetheclinicalefficacyofS１combinedwithoxaliplatinwithS１aloneintreatingeldlypatientswithadvancedgastriccancers．MethＧodsTotally８６eldlypatientswithadvancedgastriccancerswereretrospectivelyanalyzed．Casesweredividedintotwogroupsbyregimens．GroupAwastreatedwithS１alone,whilegroupBgivenS１combinedwithoxaliplatin．After４cycles,patients’performancestatus,adverseevents,responserate,following－uponeyearsurＧvivaltimeandoverallsurvivalwereevaluated．ResultsAfter４cyclesofchemotherapy,KPSimprovementhadnostatisticalsignificancebetweentwogroups(P＞０．０５)．ResponserateingroupAwaslowerthanthatingroupB(３７．１％,６７．５％),whichhadstatisticaldifference(P＜０．０１)．ThenumbersofⅡ~Ⅳleukocyte,plateＧletdeclineandperipheralnervetoxicityingroupAwerefewerthaningroupB,alsohadstatisticalsignificance(P＜０．０５)．Theoneyearsurvivalratehadnosignificantdifferencebetweentwogroups(P＞０．０５)．Kaplan－MeiersurvivalcurvedemonstratedthatgroupBhadnobettersurvivaladvantagethangroupA(P＞０．０５)．ConcluＧsionS１combinedwithoxaliplatinhadhigherresponseratecomparedwithS１aloneintreatingeldlypatientswithadvancedgastriccancers,however,sideeffectsinＧcreased,andcouldnotimprovetheoneyearsurvivalrateandoverallsurvival．Keywordsadvancedgastriccancer;eldly;S１;oxaliplatin;overallsurvival中图分类号R７３０文献标识码B文章编号１００８－６３１５(２０１５)１２－０１１９－０１