简介：Propofolpreconditioninghasbeenshowntoprovideneuroprotectionagainstspinalischemia/reperfusioninjury.Inthisstudy,spinalcordischemia/reperfusioninjurywasinducedbyblockingtheabdominalaortainrabbitsfor40minutes.Resultsshowedthattheco-applicationofpropofolpreconditioningandpostconditioningregimenamelioratedpathologicalinjuryoftheischemicspinalcordandsuppressedtheelevationofmalondialdehydelevelsandincreasedsuperoxidedismutaseactivitiesinthespinalcordtissues.Co-applicationofpropofolpreconditioningandpostconditioningresultedinpotentprotectiveeffectsagainstspinalcordischemia/reperfusioninjuryandprolongedthespinalcord'stolerancetoischemia.Thisprotectionwasassociatedwiththeanti-lipidperoxidationcapacityofthespinalcordtissues.
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