简介:Nasopharyngealcarcinoma(NPC)isacommonheadandneckmalignancy.TheincidenceofNPCishigherinSouthernChinaandSoutheastAsiacomparedwithWesterncountries.Givenitshighradiosensitivity,thestandardtreatmentforNPCisradiotherapy.However,radioresistanceremainsaseriousobstacletosuccessfultreatment.Radioresistancecancauselocalrecurrenceanddistantmetastasesinsomepatientsaftertreatmentbyradiation.Thus,specialemphasishasbeengiventothediscoveryofeffectiveradiosensitizers.Thisreviewaimstodiscussthebiomarkers,classifiedaccordingtothemainmechanismsofradiosensitization,whichcanenhancethesensitivityofNPCcellstoionizingradiation.