简介:Take-homeMessages.TherecentlypublishedACC/AHAcholesterolguidelinesrecommendfixed-dosestatintherapyforthoseatrisk,andalthoughnotrecommendedasfirstlinetherapy,nonstatintherapiesarerecommendedwhenlessthananticipatedtherapeuticresponsetostatintherapyoccursorwhenpatientsarenotabletotoleratestatintherapy.Nonstatincholesterol-loweringdrugsshowntoreduceatheroscleroticcardiovasculardisease(ASCVD)eventsinrandomizedcontrolledtrials(RCTs)arepreferred.Noevidencewasfoundtosupporttheuseofspecificlow-densitylipoprotein(LDL)-cholesteroltargetlevels.