简介：Wehavereviewedthegenetherapyingastrointestinaldiseases^[1].GastriccanceriscommoninChina^(2-20),anditsearlydiagnosisandtreatmentarestilldifficultuptonow^(13-36).Theex-pressionofanexogenousgeneintroducedbygenetherapyintopa-tientswithgliomascanbemonitorednon-invasivelybypositron-emissiontornography^[4].

简介：Hepatocellularcarcinoma(HCC),thepredominantformofadultlivermalignancies,isaglobalhealthconcern.Itsdismalprognosishaspromptedrecentsignificantadvancesintheunderstandingofitsetiologyandpathogenesis.Thederegulationofepigeneticmechanisms,whichmaintainheritablegeneexpressionchangesandchromatinorganization,isimplicatedinthedevelopmentofmultiplecancers,includingHCC.ThisreviewsummarizesthecurrentknowledgeofepigeneticmechanismsinthepathogenesisofHCC,withanemphasisonHCCmediatedbychronichepatitisBvirusinfection.Thisreviewalsodiscussestheencouragingoutcomesandlessonslearntfromepigenetictherapiesforhematologicalandothersolidcancers,andhighlightsthefuturepotentialofsimilartherapiesinthetreatmentofHCC.

简介：ThetreatmentofprimarygastricdiffuselargeB-celllymphoma(DLBCL)haschangedradicallyoverthelast10–15years,withtheabandonmentofroutinegastrectomyinfavorofmoreconservativetherapies.Low-levelevidencesuggeststhatconsolidationradiotherapycouldbeavoidedinpatientswithlimited-stageDLBCLofthestomachwhoachievecompleteremissionafterrituximab-CHOPcombination.Small,recentprospectivetrialssuggestthatselectedpatientswithlimited-stageHelicobacterpylori(H.pylori)-positiveDLBCLofthestomachandfavorableprognosticfactorscanbemanagedwithantibioticsalone,withexcellentdiseasecontrolandcurerates,keepingchemo-radiotherapyforunresponsivepatients.Thisrecommendationshouldequallyregardpatientswithmucosa-associatedlymphoidtissue-relatedordenovoDLBCL.FuturestudiesshouldbefocusedontheestablishmentofreliablevariablesabletodistinguishthebestcandidatesforexclusivetreatmentwithH.pylorieradicationfromthosewhoneedforconventionalchemo-immunotherapy.

简介：Thecurrentulcerativecolitis(UC)treatmentalgorithminvolvesastep-uptherapeuticstrategy,mainlyaimingatinducingandmaintainingitsclinicalremission.Althoughthistherapeuticstrategymayseemtobecost-efficientandreducetheriskofsideeffects,recenttrialsandcasereportshaveshownthattop-downtherapyusingin·iximabinducesarapidclinicalresponse,enhancespatientqualityoflife,promotesmucosalhealing,reducessurgeriesandindirectcostoftreatmentforpatientswithsevereUC.Moreover,sincelong-termtreatmentwithin·iximabissafeandwelltolerated,earlyaggressivetop-downtherapeuticstrategymaybeamoreeffectiveapproach,atleastinasubgroupofsevereextensiveUCpatients.

简介：AIM:Tostudytheeffectsofglutamine(Gin)onthechangeofintestinalpermeabilityanditsrelationshiptosystemicinflammatoryresponseinearlyabdominalpostoperativepatients.METHODS:Aprospective,randomized,double-blindandcontrolledtrialwastaken.TwentypatientsundergoingabdominalsurgerywererandomizedintoGingroup(oraladministrationofglutamine,30g/d,for7d,n=10)andplacebogroup(oraladministrationofplacebo,30g/d,for7d,n=-10).Temperaturesandheartratesofallpatientsweredailyrecorded.Whitebloodcellcounts(WBC)andbiochemicalvariablesweremeasuredbeforeoperationand4and7dalterdrugadministration.Serumconcentrationsofglutamine,endotoxin,diamineoxidaseandmalondialdehydeandurinelactulose/mannito(L/M)ratioweremeasuredbeforeand7dalterdrugadministration.RESULTS:Thepatientsinthe2groupswerecomparablepriortodrugadministration.SerumGinconcentrationwassignificantlydecreasedintheplacebogroupandincreasedintheGingroup7dalterdrugadministration.UrineL/MratiowassignificantlyincreasedintheplacebogroupanddecreasedintheGingroup.Theserumconcentrationofendotoxin,diamineoxidaseandmalondialdehydewassignificantlydecreasedintheGingroupcomparedwiththoseintheplacebogroup.Temperatures,heartratesandWBCcountsweresignificantlylowerintheGingroupthanthoseintheplacebogroup.CONCLUSION:Gutisoneofthesourcesofsystemicinflammatoryresponseinabdominalpostoperativepatientsandglutaminecandecreaseintestinalpermeability,maintainintestinalbarrierandattenuatesystemicinflammatoryresponseinearlypostoperativepatients.

简介：Thisreviewaimsatevaluatingtheexistingevidenceregardingpostreperfusionsyndrome,providingadescriptionofthepathophysiologicmechanismsinvolvedandpossiblemanagementandpreventivestrategies.APubMedsearchwasconductedusingtheMeSHdatabase,＂Reperfusion＂AND＂livertransplantation＂werethecombinedMeSHheadings;EMBASEandtheCochranelibrarywerealsosearchedusingthesameterms.52relevantstudiesandoneongoingtrialwerefound.Theconceptofpostreperfusionsyndromehasevolvedthroughyearstoamultisystemicdisorder.Theimplicationsofthemainorgan,recipientandprocedurerelatedfactorsinthegenesisofthiscomplexsyndromearediscussedinthetextasthenovelpharmacologicandtechnicalapproachestoreduceitsincidence.Howevertheavailableevidenceaboutriskfactors,physiopathologyandpreventivemeasuresisstillconfusing,thepresenceoftwomaindefinitionsandthenumerosityofpossibleconfoundingfactorsgreatlycomplicatestheinterpretationofthestudies.

简介：瞄准：在试验性的老鼠在生物化学、组织病理学说的变化，氧化压力，和细菌的易位(BT)上调查allopurinol和高比重的氧(HBO)治疗的单个、联合的效果尖锐胰腺炎(AP)。方法：85只Sprague-Dawley老鼠在学习被包括。85只老鼠中的十五个被用作控制(假冒，组我)。AP在留下经由管内牛磺胆酸盐注入被导致七十只老鼠。幸存到尖锐引起坏死胰腺炎的正式就职的老鼠被使随机化进四个组。组II独自收到了saline，组IIIallopurinol，加HBO的组IVallopurinol和组VHBO。浆液淀粉酶层次，氧化压力参数，BT和组织病理学说的分数是坚定的。结果：浆液淀粉酶层次在与组II相比的组III，IV和V是更低的(974+/-110，384+/-40，851+/-56，和1664+/-234U/L，分别地P<0.05，为所有)。联合揭示的二种处理选择显著地降低median[25-75百分位数]组织病理学说的分数什么时候与单个政府相比(13[12.5-15]在allopurinol组，9.5[7-11.75]在HBO组，并且6[4.5-7.5]在联合的组，P<0.01)。氧化压力标记在与控制相比的所有处理组显著地更好。进胰和mes伤寒淋巴结的细菌的易位在与组II相比的组III，IV和V是更低的(54%，23%，50%对为到胰的易位的100%，并且62%，46%，58%对为到mes伤寒淋巴节点的易位的100%，分别地P<0.05为所有)。结论：当在试验性的老鼠AP独立管理了时，现在的学习证实HBO和allopurinol处理的利益。这些处理选择的联合看起来更有效地阻止胰腺的损害参数的前进。