简介：ECAPsarethesummaryofmultipleneurons’spikeswhichcouldberecordedbyabidirectionalstimulation-recordingsystemviathecochlearimplant,withtheartifacteliminationparadigmsofforward-maskingsubtractionparadigmoralternatingpolarityparadigm.ThreekindsofFDAapprovedcochlearimplantssupportECAPtesting.ThisarticleistosummarizetheclinicalapplicationofECAPlest.ECAPtestafterinsertionofelectrodeduringimplantoperationhasbeenwidelyusedduringcochlearimplantsurgery.Inrecentyears.ECAPthresholdsarealsousedtoestimatetheTlevelsandClevelshelpingprogramming.However,correlationbetweenECAPthresholdsandpsychophysicalthresholdsisaffectedbymanyfactors.Sofar,ECAPscannotyetbeagoodindicatorofpost-operativehearingandspeechperformance.

简介：Objective:ToevaluateHighResolutionComputerTomography(HRCT)inthediagnosisofexternalearcanalcholesteatoma.Methods:Inthisretrospectivestudy,HRCTsof27patientswithexternalearcanalcholesteatomawerereviewed.Thechangesintheexternalearcanal,tympanicmembrane(TM),scutum,tympanumandmastoidweremeasuredandcategorized.Results:Fourteenpatientsshowednoormilddestructionintheexternalearcanal(stageIgroup).Eightpatientshadobviousenlargementintheexternalearcanal(stageIIgroup)butshowedlimiteddestructionsofthemastoidboneandnodamageofthetympanums.Fivepatientshadseriousdestructionofthemastoidboneanddamageofthetympanum(stageIIIgroup).AllpatientsinthestageIIIgroupshowedacompressionofmanubriumsandTMs,with3havingdamagesonossicularchain.BonedestructionoftheverticalsectionoffacialnervecanalwasdiscoveredinonecaseinthestageIIIgroup.Conclusion:HRCTcanprovidedetailinformationabouttheextentofexternalearcanalcholesteatoma.Suchinformationcanbeusedtoidentifyspecialsituationswithseriouscomplicationsandtodifferentiateexternalearcanalcholesteatomafrommiddleearcholesteatoma.

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简介：ObjectiveThestudyistoidentifythecarrierrateofcommondeafnessmutationinChinesepregnantwomenviadetectingdeafnessgenemutationswithgenechip.MethodsThepregnantwomeninobstetricclinicwithouthearingimpairmentandhearingdisordersfamilyhistorywereselected.Theinformedconsentwassigned.PeripheralbloodwastakentoextractgenomicDNA.Applicationofgeneticdeafnessgenechipfordetecting9mutationalhotspotofthemostcommon4Chinesedeafnessgenes,namelyGJB2(35delG,176del16bp,235delC,299delAT),GJB3(C538T),SLC26A4(IVS72A>G,A2168G)andmitochondrialDNA12SrRNA(A1555G,C1494T).Furthergenetictestingwereprovidedtothespousesandnewbornsofthescreenedcarriers.ResultsPeripheralbloodof430pregnantwomenweredetected,detectionofdeafnessgenemutationcarriersin24cases(4.2%),including13casesoftheGJB2heterozygousmutation,3casesofSLC26A4heterozygousmutation,1casesofGJB3heterozygousmutation,and1caseofmitochondrial12SrRNAmutation.18spousesand17newbornstookfurthergenetictests,and6newbornsinheritedthemutationfromtheirmother.ConclusionThecommondeafnessgenesmutationhasahighcarrierrateinpregnantwomengroup,235delCandIVS7-2A>Gheterozygousmutationsarecommon.