简介：·Glaucomaisoneoftheleadingcausesofvisualimpairmentandblindnessworldwide.Ofknownriskfactorsforglaucoma,anincreasedinintraocularpressureismosthighlycorrelatedwithglaucomatousdamage.Irrespectiveofthecause,apoptosisoftheretinalganglioncellsistheeventualoutcome.Itiswidelyacceptedthatglaucomaisaneurodegenerativediseasethatisstronglycorrelatedwithcentralnervoussystemdisorders,suchasAlzheimer’sdisease.Thesetwodisordersalsosharesomesimilaritiesinpathogenicmechanisms.Recentstudiessuggestthatthetransientreceptorpotentialcanonical6channelcouldworktogetherwithbrain-derivedneurotrophicfactortopromoteneuronsurvivalinbrainandretina.Inthisstudy,weproposethattransientreceptorpotentialcanonical6maycontributetothepathogenesisofhumanglaucomaandbecomeapotentialtherapeutictarget.

简介：目的分析早产儿眼底疾病的发生情况、高危因素及筛查时机和范围。方法回顾分析2014年12月至2018年2月在我院眼科检查的1348例早产儿的眼底检查结果,分析早产儿视网膜病变发生的高危因素。结果1348例早产儿中,正常者23.8%,未成熟视网膜者46.4%,ROP者17.5%,眼底出血者7.1%,渗出者3.7%,其他1.5%。且体重越低、胎龄越低、吸氧时间越长、全身疾病越重严重的早产儿ROP发生率越高、程度越严重。结论低体重、胎龄小、吸氧时间过长、窒息史、严重全身疾病、多胎等是引起早产儿视网膜病变的高危因素,早产儿眼底筛查时间应适当提前、范围应适当放宽。