简介:·AIM:Tostudytheeffectsofdanhonghuayukoufuye(DHK)onfastingbloodglucose(FBG)anddiabeticretinopathy(DR)instreptozotocin(STZ)-inducedtype1diabeticratstofacilitatetherationalusageofthisdrug.·METHODS:DiabeticratswereinducedbyinjectionofasingledoseofSTZintraperitoneallyat50mg/kg.Flashelectroretinogram(FERG)andoscillatorypotentials(OPs)wereusedtomeasureretinalfunction.Themicrovascularperfusionofearswasperformedtostudythemicrocirculationinrats.FBG,body-weight,and24-hurinevolume,waterintakeanddietintakewerealsoassessed.·RESULTS:DHKhadnoeffectonFBGinnormalrats.However,STZ+DHKgroupweresignificantlydifferentfromthoseofModelandmovedtowardthoseofnormalcontrol.Itreversedtheincreaseindietintake(P≤0.05vsmodelcontrol)andthelossinbody-weight(P≤0.05vsmodelcontrol)indiabeticrats.DHKdecreasedtheFBGofdiabeticratsby25.6%(P≤0.05)and37.9%(P≤0.01)after14and21daysadministrationascomparedwiththemodelcontrol,respectively.Moreover,DHKsignificantlyincreasedtheFERGb-waveamplitudeby80%(P≤0.05vsmodelcontrol)anddecreasedtheFERGb-wavelatencyby15.3%(P≤0.01vsmodelcontrol)after24daysadministration.TheOP1andOP2amplitudesinDHKgroupwere2.6(P≤0.01)and2.0(P≤0.01)timesofmodelgroupafter24daysofDHKtreatment,respectively.Atthesametime,OP1andOP2latenciesinDHKgroupreducedby16.0%(P≤0.001)and14.7%(P≤0.001)ascomparedwiththemodelcontrol,respectively.Furthermore,themicrovascularperfusionofDHKgroupwas2.4timesofmodelgroup(P≤0.001)after21daysadministration.·CONCLUSION:DHKhadnoeffectonnormalFBG.Butithadantihyperglycemicactivity,andhadapreventiveandtherapeuticeffectonDRindiabeticrats.·
简介:目的:使用Pentacam三维眼前段分析仪比较高度近视眼与正常人(正视眼)中央前房深度(centralanteriorchamberdepth,CACD)和前房角(anteriorchamberangle,ACA)两项前房参数差异,进一步了解高度近视眼的解剖学特点。方法:收集2010-10/2011-06在我院门诊就诊的正视眼82例,收集同期我院门诊与准分子激光中心就诊的高度近视眼68例,采用Pentacam三维眼前段分析仪测量CACD和ACA。对高度近视组与正视眼组的前房参数值进行两样本t检验,比较两组间参数有无差异。结果:Pentacam三维眼前段分析仪测得正常人CACD平均值为3.02±0.47mm,ACA平均值为33.26°±6.20°。高度近视眼的CACD平均值为3.24±0.38mm,ACA的平均值为39.55°±6.68°。高度近视眼与正视眼的两项前房参数值均存在显著性差异(均P〈0.05)。结论:Pentacam三维眼前段分析仪测量前房参数,高度近视眼与正视眼相比中央前房深度深、前房角宽。
简介:目的对眼科住院医师实施白内障囊外摘除术及人工晶体植入术中,手术并发症的预防及处理能力培训探讨。方法开展防盲治盲工作中,住院医师共施行215例(235只眼)的白内障囊外摘除术及人工晶体植入手术,对发生并发症进行回顾性分析。结果术后发生的手术并发症:后囊破裂15只眼(6.4%),虹膜脱出5只眼(2.1%),虹膜根部离断3只眼(1.3%),角膜水肿45只眼(19.1%),瞳孔上移10只眼(4.3%),前房皮质残留2只眼(0.9%),后囊瞳孔区皮质残留2只眼(0.9%),继发性瞳孔阻滞性青光眼1只眼(0.4%),黄斑囊样水肿1只眼(0.4%)。结论后囊膜破裂和角膜水肿是本组白内障囊外摘除术及人工晶体植入手术主要并发症,住院医师手术者应规范掌握手术要点是预防并发症发生的关键,对出现的手术并发症应积极妥善处理是减少并发症有效措施。
简介:目的:观察翼状胬肉切除联合自体球结膜瓣移植术后,局部应用1g/L环孢霉素A对胬肉复发的抑制效果。方法:对原发性翼状胬肉患者58例58眼进行前瞻性研究。所有入选眼均采用翼状胬肉切除联合自体球结膜瓣移植术,根据术后是否应用1g/L环孢霉素A滴眼液分为试验组和对照组。术后追踪随访1a,观察患者的胬肉复发率。结果:术后试验组基础泪液分泌试验(SchirmerⅠtest,SⅠt)结果明显优于对照组(9.93±1.59vs8.47±1.53mm/5min);SⅠt结果也显示1g/L环孢霉素A使患眼术后的泪液分泌量较术前有所增加。术后1a试验组与对照组的胬肉复发率分别为10%和39%。对照组并发症的出现率要高于试验组,差异具有统计学意义(P=0.029)。结论:翼状胬肉切除术后局部应用1g/L环孢霉素A滴眼液能够安全有效地降低胬肉的复发率。