简介：Severalriskfactors,whichincludeheredity,ultra-violet(UV)lightandchronicinflammation,contributetopterygiumdevelopment.However,thereisnoreportintegratingthesefactorsinthepathogenesisofpterygium.Theaimofthisreviewistodescribetheconnectionbetweenheredity,UV,andinflammationinpterygiumdevelopment.ExistingreportsindicatethatsunlightexposureisthemainfactorinpterygiumoccurrencebyinducinggrowthfactorproductionorchronicinflammationorDNAdamage.Hereditymaybeafactor.Ourstudiesonfactorsinpterygiumoccurrenceandrecurrenceidentifythatheredityiscrucialforpterygiumtodevelop,andthatsunlightisonlyatrigger,andthatchronicinflammationpromotespterygiumenlargement.WeproposethatgeneticfactorsmayinterferewiththecontroloffibrovascularproliferationwhileUVlightor(sunlight)mostlikelyonlytriggerspterygiumdevelopmentbyinducinggrowthfactorswhichpromotevibrantfibrovascularproliferationinpredisposedindividuals.Italsojusttriggersinflammationandcollagenolysis,whichmaybepromotersoftheenlargementofthefibrovascularmass.Pterygiumprobablyoccursinthepresenceofexuberantcollagenproductionandprofuseneovascularisation.

简介：AIM:ToscreenmicroRNAs（miRNAs）andsetuptargetmiRNAsinpterygium.METHODS:PrimaryfibroblastswereisolatedfrompterygiumandTenon’scapsuleandcultured.ImmunocytochemicalanalysisandWesternblottingwereperformedtoconfirmthecultureoffibroblasts.Inall,1733miRNAswerescreenedinthefirststepbyusingGeneChip?miRNA3.0Array.SpecificmiRNAsinvolvedinthepathogenesisofpterygiumweresubsequentlydeterminedusingthefollowingcriteria:1)highreproducibilityinarepetitivetest;2)baselogvalueof>7.0forbothcontrolandpterygialfibroblasts;and3)logratioof>1.0betweenpterygialfibroblastsandcontrolfibroblasts.RESULTS:Primaryscreeningshowedthat887/1733miRNAswereup-regulatedand846/1733miRNAsweredown-regulatedinpterygialfibroblastscomparedwiththoseincontrolfibroblasts.Ofthe1733miRNAsscreened,4miRNAs,namely,miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5pandmiRNA-411a-5p,mettheabove-mentionedcriteria.Primaryscreeningshowedthatthese4miRNAswereup-regulatedinpterygialfibroblastscomparedwithcontrolfibroblastsandthatmiRNA-143a-3phadthehighestmeanratiocomparedwiththemiRNAsincontrolfibroblasts.CONCLUSION:miRNA-143a-3p,miRNA-181a-2-3p,miRNA-377-5pandmiRNA-411a-5pareup-regulatedinpterygialfibroblastscomparedwithcontrolfibroblasts,suggestingtheirinvolvementinthepathogenesisofpterygium.

简介：AIMTo把主要、周期性的pterygium外科的长期的结果与三种不同技术作比较：联合结膜自体移植和覆盖羊膜的膜移植(有AMT的猫)，结膜自体移植移植(猫)独自一个、羊膜的膜移植(AMT)alone.METHODSIn这回顾的研究，142个pterygium病人的142只眼睛(104主要，38周期性)经历了猫(组A)，AMT(组B)或有AMT(组C)的猫分别地后面的外科的切除基于复发和手术后的complications.RESULTSThe数字被考察并且比较一样的描述在下面)，18(10，8)并且2(1，1)在组A，B，和C分别地；干燥眼睛是22(16，6)，27(18，9)并且7(3，4)；结膜发炎是30(17，13)，27(16，11)并且11(6，5)。在组C(主要或周期性的任何一个或两个)的病人主要在组A或B比那些显示出显著地更好的结果(P<0.05)关于上述临床的effects.CONCLUSIONCombined猫并且过分AMT比猫或AMT为主要、周期性的pterygium外科有复发和手术后的复杂并发症的显著地更低的率独自一个。