简介：Retinoblastoma(RB)isthemostcommonintraocularcancerofinfancyandchildhood.ThiscancerisinitiatedbymutationonRB1,thetumorsuppressorgenethatisresponsiblefortheregulationofbothcellcycleandgnomestabilityinretinalcells.PatientswithaconstitutionalmutationonRB1canbeinherited.RBoccursapproximately1inevery15000-20000livebirths.Theworldwidemortalityforthiscancerisabout5%-11%.However,thisraterisestoabout40%-70%indevelopingcountriesduetoadelayindiagnosis.Awidevarietyofoptionsareavailableforthetreatment,butoftenacombinationoftherapiesisadoptedtooptimizeindividualizedcare.

简介：neovascularization的形成是许多眼睛的脉管的疾病的一个普通病理学的特征，并且是在病人的视觉损失的一个重要原因。Neovascularization能引起网膜的出血，玻璃的出血，和另外的严肃的复杂并发症，导致视觉的损失。intraocularneovascularization的治疗是眼科学研究的焦点。在最近的年里，一些研究发现了autophagy是仔细与脉管的endothelial生长因素和neovascularization的形成有关。Autophagy被期望为intraocularneovascularization的治疗成为一个新目标。因此，这篇文章在autophagy和intraocularneovascularization的形成上考察研究。

简介：DearEditor,IamDr.KhayWeiPohfromDepartmentofOphthalmology,HospitalKualaLumpur,Malaysia.IwritetoshareacaseofdiffusechoroidalhaemangiomainachildwithSturgerWebersyndromewhoshowedresolutionofexudativeretinal

简介：AIM:Toreviewpublishedclinicalstudiesexaminingtheeffectofnatamycininthetreatmentoffungalkeratitis.METHODS:WeselectedthepublicationsinCENTRAL,MEDLINE,EMBASE,CNKI,andCBM.Thisstudysystematicallyreviewedpublishedrandomizedcontrolledtrials(RCTs)thatcomparednatamycintootherantifungalagents,andconductedfeasibleMeta-analysisofefficacyresultsusingRevman5.2software.RESULTS:WeincludedseventrialswhichweremainlycarriedoutindevelopingcountriesofAsia,withfivetrialsconductedinIndia,oneeachinChinaandBangladesh.Atotalof804participantswererandomizedtofollowingcomparisons:2%econazoleversus5%natamycinshowedlittledifferenceintheeffectsoftreatmentoffungalkeratitis[RR=0.99,95%confidenceinterval(CI),0.8to1.21];chlorhexidinegluconateversus5%natamycinindicatedthattheresultsonhealingoftheulcerat21dwaslessconclusive(RR=0.77,95%CI,0.55to1.08;I2=0%);1%voriconazoleversus5%natamycinsuggestedthatnatamycintreatmentappearedtobesignificantlybetteroutcomesthanvoriconazole(regressioncoefficient=-0.18logMAR;95%CI,-0.30to-0.05;P=0.006),especiallyinFusariumcases(regressioncoefficient=-0.41logMAR;95%CI,-0.61to-0.20;P<0.001);natamycinversusfluconazoleshowedasignificantdifferenceincurerate(χ2=5.048,P<0.05)andnatamycingroupwasmoreeffectivethanfluconazoleinaverageperiodoftherapy(t=7.94,P<0.01).CONCLUSION:Natamycinwasapreferablechoiceinthetreatmentoffungalkeratitis,especiallyintheearlyperiodofFusariumcases.

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简介：AIMTo为Snellen和早治疗糖尿病的Retinopathy学习(ETDRS)图表比较精确性，重制度和测试持续时间，二个主要工具过去常测量视觉尖酸(VA).METHODSA计算机模拟被规划运用多重虚拟病人，有分配参数的一个唯一的集合的各个，包括VA，假积极、假否定的错误珍视。为各个，虚拟耐心的、分配VA随机沿着跨越在1.0～0.0个logMAR单位(到到20/20的20/200的等价物)之间的范围的连续规模被选择。每30000个虚拟病人在每二VAcharts.RESULTSAverage测试持续时间上被运用十次(表示了为在测试±期间介绍的人物的全部的数字；SD)是12.6±；11.1和31.2±；14.7个人物为Snellen和ETDRS，分别地。精确性，定义为绝对差别(±；SD)在分配VA和测量VA之间，在logMAR表示了单位，在ETDRS图表是优异的：0.12±；0.14和0.08±；0.08为Snellen和ETDRS图表，分别地。重制度，表示了可变性为测试网，在ETDRS图表是优异的：0.23±；0.17和0.11±；0.09个logMAR单位为Snellen和ETDRS图表，respectively.CONCLUSIONA比较真(分配)VA到测量VA，平均，更好证明ETDRS的精确性和重制度制图，但是在显著地更长的测试持续时间的惩罚。这些差别最在低VA范围被读。用一条模拟途径的重制度与在几临床的研究发现的重制度价值一致。

简介：这研究在跟随加速的transepithelial的keratoconus角膜评估了临床的结果角膜的骨胶原cross-linking(CXL)(AvedroKXL?系统，麻省沃尔瑟姆，美国)超过一年后续。光连贯断层摄影术(10月)测量的分界线的吝啬的深度是205.19???吳????????<

简介：AIM:Toevaluatethelong-termresponsetothefixedcombinationofdorzolamide/timololinpatientswithprimaryopenangleglaucoma(POAG)andtheadditionofotherintraocularpressure(IOP)loweringmedicationssuchasprostaglandinanalogsandbrimonidine.METHODS:Aretrospective,non-randomized,anddescriptiveclinicalstudywasperformedwith182eyesdiagnosedwithPOAG.Patientsweredividedintothreegroups:agroupwithfixedcombinationofdorzolamide/timololonly,asecondgroupwithprostaglandinanalogsplusfixedcombinationofdorzolamide/timolol,andathirdgroupwiththeadditionofbrimonidinetothesamefixedcombination.IOPdataweregatheredretrospectivelyandthedifferencesbetweengroupswerecalculated.RESULTS:IOPwasreducedsatisfactorilyinallthreegroups;however,aprogressiveIOPreductionwasnotedinthegroupwiththefixedcombinationplusprostaglandinanalogs.Inthisgroup,aprogressive,significantandmorehomogeneousresponseofthereductionwasnotedincomparisonwiththeothergroups.CONCLUSION:IOPreductionwasefficaciousinallthreegroups.TheadditionofprostaglandinanalogsshowedprogressiveIOPreduction,progressiveresponseandabsenceoflong-termdrift.Brimonidinedidnotshowasignificantadditiveeffect.

简介：AIMTo在transepithelial以后评估组织学的变化用在试验性的兔子研究的部分厚度excimer激光脱离或上皮的乙醇申请的角膜的crosslinking(CXL)。

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简介：　　角膜作为人眼屈光系统的重要组成部分,其地形、屈光力和厚度的准确测量直接决定着屈光手术的设计和角膜疾病的诊断.通常角膜地形图仪测量角膜前表面的地形,是角膜屈光力的主要来源,近年的研究表明角膜后表面的形状同样也影响着角膜的屈光力[1].角膜的厚度影响着内皮细胞层的屏障和泵功能,它的准确测量对于角膜疾病的诊断和避免屈光手术术后圆锥角膜的发生起着重要的作用[2].……

简介：在反脉管的endothelial生长的一个年以后与有斑点的浮肿的分辨率和foveal消沉的恢复在眼睛报导foveal厚度减小为包含中心的糖尿病的有斑点的浮肿(DME)的因素(anti-VEGF)治疗.METHODSFoveal厚度与光连贯断层摄影术被估计决定中央子字段foveal厚度(CSFT)并且在有DME的42只眼睛的有斑点的体积(CSFT>275湥獴愠?潣灭牡摥琠?敨污桴?潣瑮潲?牧畯？

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简介：AIM:Tocomparetheeffectsofintravitrealinjectionofbevacizumab(IVB)withintravitrealtriamcinoloneacetonide(IVTA)onthetreatmentofcystoidmacularedema(CME)secondarytoretinalveinocclusion(RVO).·METHODS:AliteraturesearchwasconductedusingPubMed,theCochraneCentralRegisterofControlledTrials,WebofScienceandtheChineseBiomedicalDatabase.Thecomparisonwasdividedintotwogroups,group1conductedcomparisoninbranchRVO(BRVO)orcentralRVO(CRVO),group2conductedcomparisoninischemic-RVOornonischemic-RVO.Pooledmeandifferences(MDs)forchangesinvisualacuity(VA),centralmacularthickness(CMT)andintraocularpressure(IOP)werecalculatedingroupsat4,12and24wkaftertreatmentrespectively.·RESULTS:EightstudiescomparingtheefficacyofIVBwithIVTAwereincludedintheMeta-analysis.Ingroup1,inBRVO,significantdifferencewasshownonthecomparisonofCMTat24wk(MD,-45.66;95%CI,-76.03to-15.28;P=0.003),IVBwaseffectiveonBRVOforatleast24wk;nosignificantdifferenceswerefoundinthecomparisonofVAateachtimepoints(P>0.05respectively).InCRVO,nosignificantdifferenceswerefoundinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).Ingroup2,inischemic-RVO,significantdifferenceswereshowninthecomparisonofVA(MD,-0.28;95%CI,-0.42to-0.14;P<0.0001)andCMT(MD,-86.50;95%CI,-151.18to-22.43;P=0.008)at24wk;Innonischemic-RVO,nosignificantdifferencesweredemonstratedinthecomparisonofVAorCMTbetweenIVBandIVTAateachtimepoints(P>0.05,respectively).TheoccurrenceofhighIOPwasmuchlowerinIVBgroup.·CONCLUSION:ThisMeta-analysissuggestedthatIVBwaseffectiveindecreasingCMTinBRVOforatleast24wk,IVBismoreeffectiveonimprovingVAandreducingCMTinischemic-RVO.IVBismorepromisingonRVOthanIVTA.

简介：AIM:Tocomparetheefficacyandsafetyofcombinationofranibizumabwithphotodynamictherapy(PDT)vsranibizumabmonotherapyinthetreatmentofage-relatedmaculardegeneration(AMD).METHODS:TheCochraneCentralRegisterofControlledTrials(CENTRAL)intheCochraneLibrary,Pubmed,andEmbaseweresearched.Therewerenolanguageordatarestrictionsinthesearchfortrials.Onlyrandomizedcontrolledtrials(RCTs)wereincluded.MethodologicalqualityoftheliteratureswasevaluatedaccordingtotheJadadScore.RevMan5.2.6softwarewasusedtodothemeta-analysis.RESULTS:Sevenstudieswereincludedinoursystematicreview,amongwhichfourofthemwereincludedinquantitativeanalysis.Theresultshowsthattheranibizumabmonotherapygrouphadabettermeanbestcorrectedvisualacuity(BCVA)changevsbaselineatmonth12comparedwiththatofthecombinationtreatmentgroup,andthestatisticaldifferencewassignificant(WMD,-2.61;95%CI,-5.08to-0.13;P=0.04).However,aftertheremovalofonestudy,thedifferencebetweenthetwogroupsshowednosignificantdifference(WMD,-2.29;95%CI,-4.81to0.23;P=0.07).Meanwhile,nosignificantcentralretinalthickness(CRT)reductionwasfoundinthecombinationtreatmentgroupandtheranibizumabmonotherapygroupat12monthsfollow-up.Nevertheless,thecombinationgrouptendedtohaveagreaterreductioninCRT(WMD,-4.13μm;95%CI,-25.88to17.63,P=0.71).Theproportionofpatientsgainingmorethan3linesatmonth12intheranibizumabgroupwashigherthaninthecombinationgroupandtherewasasignificantdifference(RR,0.72;95%CI,0.54to0.95;P=0.02).Whereastherewasnosignificantdifferencefortheproportionofpatientsgainingmorethan0lineatmonth12betweenthetwogroups(RR,0.93;95%CI,0.76to1.15;P=0.52).Thegeneraltendencyshowsareductioninranibizumabretreatmentnumberinthecombinationtreatmentgroupcomparedwiththeranibizumabmonotherapygroup.Asmajoradverseevents,thedifferencesinthenumberofeyepain,endophthalmitis,hypertensionandarterialt

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简介：目的：通过对视网膜脱离患者术前、术后的血流动力学研究及视网膜功能的了解,判断视网膜脱离患者的术后恢复情况,并探讨两种检测方法的临床价值。方法：对我院62例孔源性视网膜脱离患者,通过彩色多普勒（CDI）检测视网膜中央动脉（CRA）的收缩期峰值流速（Vmax）、舒张末期流速（Vmin）、阻力指数（RI）;多焦视网膜电图（mfERG）分别对视网膜脱离患者的术前、术后进行检测,并以对侧正常眼作对照组。结果：CDI术前患眼与对照眼的CRA各项指标比较,差异无统计学意义。术后2wk视网膜脱离眼CRA的Vmax,Vmin均较术前降低,RI增高,差异有统计学意义（P〈0.05）。视网膜脱离术后患者脱离区mfERG的a波、b波振幅密度均明显高于术前,潜伏期比手术前明显缩短,有统计学意义（P〈0.05）。结论：通过mfERG,CDI的联合检测能及时了解视网膜脱离术后的视网膜复位情况及硅胶海绵垫压后CRA的血流情况,从而避免视网膜脱离术后视网膜部分复位不良,巩膜因缺血引起局部坏死等情况发生。

简介：目的：探讨高度近视黄斑病变的光学相干断层扫描（OCT）和眼底荧光血管造影（FFA）的形态学特征、分类和对比分析。方法：对入选的高度近视黄斑病变患者61例101眼均行标准对数视力表检查，验光确定屈光度及最佳矫正视力（BCVA），并用IOL-Master测量眼轴长度。入选者需在同一天内行散瞳眼底检查、OCT及FFA检查，必要时行眼底联合造影（FFA＆ICGA）。分析不同类型的OCT及FFA形态学特征之间的相互联系，并探讨其与屈光度、最佳矫正视力、眼轴长度及中心凹厚度之间的关系。结果：FFA分类的漆样裂纹型在OCT分类的1型中所占比例为57．14％，显著高于新生血管型和黄斑萎缩型（21.43％），差异有统计学意义（P＜0．05）。FFA分类的黄斑萎缩型在OCT分类的2型中所占的比例为67．80％，显著高于漆样裂纹型（18．64％）和新生血管型（13．56％），差异有统计学意义（P＜0．05）。OCT3型均属于FFA分类的黄斑萎缩型。OCT1型的屈光度、眼轴长度明显低于2型和3型，而最佳矫正视力和中心凹厚度则明显高于2型和3型。FFA的漆样裂纹型与新生血管型在屈光度及眼轴长度上虽无明显差异，但后者的BCVA及中心凹厚度显著低于前者（P＜0．05）。漆样裂纹型及新生血管型的屈光度、眼轴长度均显著低于黄斑萎缩型，最佳矫正视力则明显高于黄斑萎缩型（P＜0．05）。结论：高度近视黄斑病变的OCT和FFA形态学特征密切相关，结合OCT和FFA的图像特征对高度近视黄斑病变形态学改变进行对比分析，不仅有助于明确病变的性质，提高我们对疾病发病机制及预后转归的认识，更为临床诊疗提供了有力的支持。

简介：目的：通过多焦视网膜电图（multifocalelectroretinography,mf-ERG）在中心性浆液性脉络膜视网膜病变（centralserouschorioretinopathy,CSC）治疗前后的观察,提高CSC诊断的准确性,并指导临床诊疗,评估预后。方法：设置有比较性的CSC观察组和双眼正常的对照组。观察组有31例CSC患者都是单眼发病,这些患者每只眼（包括患眼与对侧眼）在发病期与恢复期都经过眼科的系统检查,包括最佳矫正视力、眼底荧光血管造影、OCT和mf-ERG,并记录这些检查的数据。对照组有30例,与观察组年龄范围相同,同样做上述检查并记录数据。对两组数据进行对比分析。结果：在CSC发病期,mf-ERG显示患眼平均视网膜振幅密度在1环为60.54±18.20nV/degree2,比对照组（110.94±31.20nV/degree2）低45.43%（P〈0.01）,在2环为38.12±10.81nV/degree2,比对照组（60.91±11.43nV/degree2）低37.42%（P〈0.05）。在恢复期,mf-ERG显示患眼平均视网膜振幅密度在1环为93.71±14.13nV/degree2,比对照组（110.94±31.20nV/degree2）低15.53%（P〈0.05）;在2环为51.16±10.34nV/degree2,比对照组（60.91±11.43nV/degree2）低16.01%（P〈0.05）。另外,我们还发现,观察组31例患者中有8例对侧眼也显示出异常,平均视网膜振幅密度在1环为62.41nV/degree2,其余23例患者对侧眼未发现异常。结论：多焦视网膜电图有助于中心性浆液性脉络膜视网膜病变患者的临床治疗与随访观察,对中心性浆液性脉络膜视网膜病变患者的诊断、病情评估及预后都起着重要的作用。

简介：目的探讨和总结“复明一号”眼科流动手术车在农村地区行白内障复明手术围手术期的管理方法。方法对“复明一号流动手术车”2012年在农村地区施行的5483例白内障手术联合人工晶体植入手术围手术期管理方法进行回顾性分析和总结。结果在“复明一号”眼科流动手术车上施行的5483例白内障复明手术无一例严重的术中术后并发症发生。结论在眼科流动手术车上施行大规模白内障复明手术除严格遵守常规的围手术期护理方法外，还要结合农村地区的条件和在车上进行手术的特点制定实施围手术期管理方法，以减少手术并发症，使白内障复明手术安全高效。