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简介：Cytarabine(1-β-D-arabinofuranosylcytosine,Ara-C),isolatedfromaCaribbeanspongespeciesTethyacrypta,isthefirstantitumordrugfromamarineresource.In1980,theUSFoodandDrugAdministrationapprovedthisdrugforthetreatmentofdifferenttypesofleukemia.Thisdrughasashortplasmahalf-life,lowstability,limitedbioavailability,andseveresideeffects.Toimprovestabilityandbioavailability,wesynthesizedninenovelderivativesbyblockingthecytarabinemetabolicsitesandimprovinglipophilicity.ThecLogPvaluesofthenewlysynthesizedcompoundswerecalculated.Allthesynthesizedcompoundsweremorelipophilicthancytarabine,resultinginmembranepermeabilityandbioavailabilityimprovement.TheantitumoractivitiesagainstleukemiacelllineHL-60wereevaluatedbyusingtheMTTassay.ThebioassayresultsrevealedthattheIC50valuesofcompounds5,8and9were0.080,0.090and0.057μmolL-1,respectively,whichwassimilarwiththatofcytarabine(0.056μmolL-1).Incomparison,compound4withaphosphategroupatO5’wasinactive.Becausephosphoesterbondsareeasilyhydrolyzedbyalkalinephosphataseandarecommonlyusedinproducingprodrugstrategies,compound4mightalsobemetabolizedinvivoandgeneratecompound3orevencytarabinethroughamulti-stepreaction.Thus,compound4mightbeapromisingcompoundtobedevelopedasaprodrug.

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简介：富县区块盒1段属于低孔低渗致密气藏，现场压裂过程中多次发生砂堵，因此需要对区块岩石力学特征开展深入研究。通过多元线性回归的方法利用测井曲线及实验测试结果建立了富县区块盒1段岩石力学参数计算模型，并对多口井岩石力学剖面进行计算，统计分析了不同岩性杨氏模量及泊松比数值分布规律，采用克里金插值方法及岩性条件约束得到了岩石力学参数平面分布规律，为压裂设计优化提供借鉴。

简介：1概况近年来，中国气象局和中国民用航空局、香港天文台联合建设了亚洲航空气象中心，旨在促进航空气象服务。亚洲航空气象中心经过6次联合工作组会议和1次高层专职小组会议推动了三方合作，并完成了初期总体工程建设。

简介：Amapoftheaverageatomicnumberoflunarrockandsoilcanbeusedtodifferentiatelithologyandsoiltypeonthelunarsurface.Thispaperestablishesalinearrelationshipbetweentheaverageatomicnumberoflunarrockorsoilandthefluxofpositionannihilationradiation(0.512-MeVgamma-ray)fromthelunarsurface.TherelationshipisconfirmedbyMonteCarlosimulationwithdatafromlunarrockorsoilsamplescollectedbyLuna(Russia)andApollo(USA)missions.AmapoftheaverageatomicnumberofthelunarrockandsoilonthelunarsurfacehasbeenderivedfromtheGamma-RaySpectrometerdatacollectedbyChang’e-1,anunmannedChineselunar-orbitingspacecraft.Inthemap,thehigheraverageatomicnumbers(ZA>12.5),whicharerelatedtodifferenttypesofbasalt,areinthemariaregion;thehighestZA(13.2)readingsareassociatedwithSinusAestuum.ThemiddleZA(~12.1)regions,intheshapeofirregularovalrings,areinWestOceanusProcellarumandMareFrigoris,whichseemstobeconsistentwiththedistributionofpotassium,rareearthelements,andphosphorusasauniquefeatureonthelunarsurface.Theloweraverageatomicnumbers(ZA<11.5)arefoundtobecorrelatedwiththeanorthositeonthefarsideoftheMoon.

简介：地图学cartography研究模拟和数字地图的理论、技术以及应用的学科。理论地图学theoreticalcartography研究地图学的基础理论（地图空间认知、地图信息传输等）、应用理论（地图模型、地图感受、地图符号、地图功能等）和地图学发展历史的学科。实用地图学appliedcartography研究模拟和数字地图的设计、编绘、制版卬刷、地图分析和应用的学科。

简介：TheeffectsofBacillussubtilis2-1fromtheintestineofhealthyseacucumberonthegrowth,digestiveenzymeactivitiesandintestinalmicrobiotaofjuvenileseacucumber(Apostichopusjaponicus)weredeterminedinthepresentstudy.SeacucumberwasfedwithSargassumthunbergiipowdersupplementedwithB.subtilis2-1atdifferentconcentrationsvaryingamong0(control),105,107,and109CFUg-1for8weeks.ResultsshowedthatthegrowthperformanceandintestinalamylaseandtrypsinactivitiesweresignificantlyincreasedbydietaryB.subtilis2-1at109CFUg?1(P<0.05).However,dietaryB.subtilis2-1hadnosignificantinfluenceonthelipaseactivityinseacucumber(P>0.05).Thepolymerasechainreactiondenaturinggradientgelelectrophoresisand16SrRNAgenesequencinganalysisindicatedthatdietaryB.subtilis2-1at105and107CFUg-1inhibitedmostoftheProteobacteriaincludingthoseingenusVibrio.DietaryB.subtilis2-1at109CFUg-1notonlydecreasedtheabundanceandspeciesofgenusVibrio,butalsoincreasedtheintensityofgeneraPsychrobacterandBacillus.AspecificdosageofdietaryB.subtilis2-1couldincreasethegrowthandmodulatetheintestinalmicrobiotaofseacucumber;thusitmightbeanovelprobioticforkeepingthehealthofseacucumber.

简介：AbstractTheGartnerkofelboreholeisoneofthemostthoroughlystudiedanddescribedPermo-Triassicsectionsintheworld.Detailedbulkorganiccarbonisotopestudiesshowanegativebaseshiftfrom-24%0to-28%0intheLatestPermianwhichlattervaluepersistsintotheEarliestTriassicafterwhichitdecreasesslightlyto-26‰.Twostronglynegativepeaksof〉-38‰intheLatestPermianandalesserpeakof-31‰intheEarlyTriassicaretoonegativetobeduetoagreaterproportionofmorenegativeorganicmatterandmustbeduetoverynegativemethaneeffects.TheoverallchangetomorenegativevaluesacrosstheBulla/Teseroboundaryfitstherelativeriseinsealevelforthistransitionbasedonthefacieschanges.ApositiveshiftinorganiccarbonisotopevaluesattheLatePermianEventHorizonmaybeduetoanincreaseinland-derivedorganicdetritusatthislevel-afeatureshownbyallTethyanPermo-Triassicboundarysectionsthoughtheseothersectionsdonothavethesamevalues.Carbonatecarbonisotopetrendsaresimilarinallsectionsdroppingby2-3unitsacrossthePermo-Triassicboundary.Gart-nerkofelcarbonateoxygenvaluesaresurprisingly,con-sideringtheubiquitousdolomitization,compatiblewithvalueselsewhereandindicatereasonabletropicaltemper-aturesof60~CintheLatestPermiansabkhasto20-40℃intheoverlyingmarinetransitionbeds.Increasedland-derivedinputattheLatePermianEventHorizonmaybeduetooffshoretransportbytsunamiswhosedepositshavebeenrecognizedinIndiaatthislevel.

简介：为研究石笋δ~（13）C与δ~（18）O在千年尺度随时间的变化关系,通过对比贵州石将军洞SJJ-1石笋的δ~（13）C与δ~（18）O变化发现二者之间既有相似性又不完全同步。千年尺度两者之间的相似性主要由δ~（13）C与δ~（18）O共同受太阳辐射驱动的东亚季风强度变化所致。通过中国地层孢粉反演的植被空间格局变化,碳氧同位素的滞后期与太阳辐射相对于植被变化的滞后时间一致。因植被中δ~（13）C随年降水量增加具有变轻趋势,因此,两者的不同步性更大可能是太阳辐射驱动的季风强度变化与植被变化的不同步性引起。

简介：为预测和评价贵州普安泥堡金矿床的成矿潜力,采用原生晕地球化学方法对10460勘探线所控制的Ⅲ-1号矿体进行原生晕轴向分带特征研究。采集了该勘探线上6个钻孔矿体附近的构造蚀变岩石样品进行ICP-AES分析。通过对各元素进行相关性分析及因子分析,选取原生晕地球化学特征研究的指示元素为Au、As、Ag、Cu、Hg、Mo、Co、Cd、Sb。综合原生晕分带图及指示元素分带序列分析,判断Ⅲ-1矿体原生晕出现了明显的分带异常,其由浅部到深部总体表现为：前缘晕元素＋尾晕元素—近矿晕—前缘晕元素＋近矿晕元素＋尾晕元素的元素异常分布序列,指示在深部存在一个或多个隐伏矿体,是造成元素异常叠加共存与轴向分带序列异常的原因。

简介：凌源-宁城盆地是松辽盆地外围南部众多具良好油气勘探前景的小盆地之一,为研究其中的油气资源情况,在牛营子地区部署和实施了油气地质调查井——牛D1井。该钻井揭示侏罗系海房沟组可能为研究区重要的烃源岩发育层系之一。系统采集了海房沟组岩心,对其进行了岩石热解、镜质体反射率、气相色谱-质谱等分析及有机地球化学研究。结果表明,海房沟组浅部多为好-很好烃源岩,而深部多为差烃源岩和非烃源岩,有机质类型均主要为Ⅱ_2和Ⅲ型;浅部烃源岩的三环萜烷、升藿烷和甾烷系列丰度较高,规则甾烷呈不对称＂V字型＂;而深部烃源岩的三环萜烷、升藿烷和甾烷系列丰度较低,规则甾烷多呈＂反L型＂。综合认为海房沟组浅部具有相对较强的生烃潜力,但牛D1井海房沟组烃源岩的成熟度较低,建议今后加强对海房沟组烃源岩展布和成熟度平面分布特征的研究。