简介：Computedtomography（CT）playsanimportantroleinthefieldofmodernmedicalimaging.Reducingradiationexposuredosewithoutsignificantlydecreasingimage＇squalityisalwaysacrucialissue.Inspiredbytheoutstandingperformanceoftotalvariation（TV）techniqueinCTimagereconstruction,aTVregularizationbasedBayesian-MAP（MAP-TV）isproposedtoreconstructthecaseofsparseviewprojectionandlimitedanglerangeimaging.Thismethodcansuppressthestreakartifactsandgeometricaldeformationwhilepreservingimageedges.Weusedorderedsubset（OS）techniquetoacceleratethereconstructionspeed.NumericalresultsshowthatMAP-TVisabletoreconstructaphantomwithbettervisualperformanceandquantitativeevaluationthanclassicalFBP,MLEMandquadratepriortoMAPalgorithms.Theproposedalgorithmcanbegeneralizedtocone-beamCTimagereconstruction.

简介：Preventionoflatecomplicationsafterlargeendoscopicresectionisinefficientwithcurrentmethods.Endoscopicshielding,asasimpleandsafetechnique,hasbeenproposedtoimprovetheincidenceoftheseevents.Differentmethods,sheetsorhydrogels,haveshowedprovenefficacyinthepreventionoflatebleedingandperforation,aswellastheimprovementoftissuerepair,inexperimentalmodelsandinclinicalpractice.

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简介：Toinvestigatetherelationshipbetweensurfaceelectromyographyandsubjectiveassessmentofmusclefatigue,20youngmalevolunteersparticipatedintheexperimentofpistolholdingandaiming.sEMGoftheanteriordeltoidwasrecordedduringtheentireprocess,whilefatigueassessments(Borgscale)werecollectedevery30s.Wedividedthesignalintoseveralpartsandthenoctavebandmethodwasusedtocalculatemeanenergyofeachpart,anequationwasderivedbasedontherelationshipbetweenthemeanenergyofsEMGandBorgscale.Theresultsshowedthatthedegreeoflocalmusclefatiguecouldbedescribedbyacubiccurve,andcouldbeusedtoevaluateandmonitormusclefatigue.

简介：DearEditor,Inarecentinterventionalcasereport,Allonetal~([1])hydratedcornealstromawithcefuroximetosealasmalltraumaticleakycornealperforationthatwasunresponsivetopriorsoftbandagecontactlensapplicationfor6d.Wewouldliketojustremindthepossiblecomplicationsofintracameralcefuroximeineyeswithalreadycompromised

简介：AstragaliRadix(AR)isoneofthemostpopularherbalmedicinesintraditionalChinesemedicine(TCM).WildARisbelievedtobeofhighquality,andsubstitutionwithcultivatedARisfrequentlyencounteredinthemarket.Inthepresentstudy,twotypesofARs(wildandcultivated)fromAstragalusmembranaceus(Fisch.)Bge.andA.membranaceusvar.mongholicus(Bge.)Hsiao,growingindifferentregionsofChina,wereanalyzedbyNMRprofilingcoupledwithmultivariateanalysis.Resultsshowedthatbothcouldbedifferentiatedsuccessfullyandcultivationpatternsorgrowingyearsmighthavegreaterimpactonthemetabolitecompositionsthanthevariety;themetabolitesresponsiblefortheseparationwereidentified.Inaddition,threeextractionmethodswerecomparedandthemethod(M1)wasusedforfurtheranalysis.InM1,theextractionsolventcomposedofwater,methanol,andchloroformintheratioof1:1:2wasusedtoobtaintheaqueousmethanol(upperlayer)andchloroform(lowerlayer)fractions,respectively,showingthebestseparation.Thedifferentialmetabolitesamongdifferentmethodswerealsorevealed.Moreover,thesucrose/glucoseratiocouldbeusedasasimpleindextodifferentiatewildandcultivatedAR.Meanwhile,thechangesofcorrelationpatternamongthedifferentialmetabolitesofthetwovarietieswerefound.TheworkdemonstratedthatNMR-basednon-targetedprofilingapproach,combinedwithmultivariatestatisticalanalysis,canbeusedasapowerfultoolfordifferentiatingARofdifferentcultivationtypesorgrowingyears.

简介：Thedevelopmentofcancernanotherapeuticshasattractedgreatinterestintherecentdecade.Cancernanotherapeuticshaveovercomeseverallimitationsofconventionaltherapies,suchasnonspecificbiodistribution,poorwatersolubility,andlimitedbioavailability.Nanoparticleswithtunedsizeandsurfacecharacteristicsarethekeycomponentsofnanotherapeutics,andaredesignedtopassivelyoractivelydeliveranti-cancerdrugstotumorcells.Weprovideanoverviewofnanoparticle-baseddrugdeliverymethodsandcancertherapiesbasedontumor-targetingdeliverystrategiesthathavebeendevelopedinrecentyears.

简介：Low-intensityfocusedultrasoundstimulation(FUS),whichpossesseshighspatialresolutionandpenetrationdepth,hasbeendevelopingrapidlyfornoninvasivebrainneuromodulationinrecentyears.Inthisletter,alow-intensityFUSsystemwasdevelopedfornoninvasivebrainneuromodulationinvivo.Theradiusofultrasonicfocalspotwasquantitativelycalculatedintheorytoevaluatethespatialresolution.Thelocalfieldpotential(LFP)ofrathippocompuswererecordedbeforeandafterFUS.TheeffectofFUSonLFPpowerspectrumwasinvestigatedbycomputingtheLFPmeanabsolutepowerandrelativepowerwithWelchalgorithm.TheexperimentresultsshowthatnoninvasiveFUScanenhanceLFPmeanabsolutepowerandaltertheLFPrelativepoweratdifferentfrequencybands.TheresultsindicatethatFUScanmodulatebrainrhythmsandhassignificantpotentialinthemodulationofneuronalandpsychiatricdiseases.

简介：AIMTo报导玻璃的出血的传染病学和发生并且在Taiwan.METHODSA回顾的基于人口的学习与玻璃的出血(VH)为病人冒险因素评估。从台湾健康保险计划的所有enrollees分析100万个题目的一件样品。所有数据从台湾健康保险研究数据库被获得，包含的耐心的性，生日，临床的访问和住院的所有记录，和诊断是在疾病的国际分类包括了编码它，第九修订，临床的修正(ICD-9-CM)。主要结果措施是到2010的VH.RESULTFrom2001的发生和风险因素，4379最新诊断了案例的数据库主张与VH被识别。在台湾的VH的平均发生每十是4.8个案例--千人年通常并且特别在在40之间变老的题目和59y与时间增加了并且当VH与proliferative糖尿病患者retinopathies或网膜的静脉吸藏被联系时。一在从2001～2010的VH的发生的毫无疑问向上的趋势被注意(为增加趋势的P值<0.001)。Univariate艇长回归分析指出了那老年(为40-59，P<0.001，HR=9.39；为60，P<0.001，HR=11.39)，男性(P=0.03，HR=1.07)并且被规定了的题目反凝结药包括了阿司匹林，warfarin和clopidogrel(P<0.001，HR=2.20)是重要风险因素因为受不了VH的VH.CONCLUSIONThe发生被估计每在台湾的10000人年是4.8个盒子。年龄，男性并且被规定了反凝结药与VH的发生被联系。

简介：Multidrugresistance(MDR)isamajorobstacletosuccessfulcancertreatmentandiscrucialtocancermetastasisandrelapse.CombinationtherapyisaneffectivestrategyforovercomingMDR.However,thedifferentpharmacokinetic(PK)profilesofcombineddrugsoftenunderminethecombinationeffectinvivo,especiallywhengreatlydifferentphysicochemicalproperties(e.g.,thoseofmacromoleculesandsmalldrugs)combine.Toaddressthisissue,nanotechnology-basedcodeliverytechniqueshavebeenactivelyexplored.Theypossessgreatadvantagesfortumortargeting,controlleddrugrelease,andidenticaldrugPKprofiles.Thus,apowerfultoolforcombinationtherapyisprovided,andthetranslationfrominvitrotoinvivoisfacilitated.Inthisreview,wepresentasummaryofvariouscombinationstrategiesforovercomingMDRandthenanotechnology-basedcombinationtherapy.

简介：Themajortherapyforischemicstrokeisthrombolytictreatment,butsevereconsequencesoccurwhenthismethodisusedtotreathemorrhagicstroke.Currently,computedtomographyandmagneticresonanceimagingareusedtodifferentiatebetweentwotypesofstroke,butthesetwomethodsarein-effectiveforpre-hospitalcare.

简介：Objective:Gastriccancer(GC)isoneoftheleadingcausesofdeathinChinaandotherAsiancountries.Recently,gastricendoscopyhasbecomethemainapproachforGCscreening,buttheidentificationofhigh-riskindividualsremainsachallengeinGCscreeningprograms.Methods:Therewere7,302patientswithchronicgastritisinvolvedinthisstudy.Endoscopicexaminationswereperformed,andtheirdemographiccharacteristicsandlifestyledatawerecollected.EachpossibleassociatedfactorofGC/premalignantandprecursorlesionswasevaluatedbyunivariateandmultivariatelogisticregressions.Nomogramswereusedforvisualizationofthosemodels,andreceiveroperatingcharacteristic(ROC)curveanalysiswasusedtopresentthepredictiveaccuracy.Results:Wedetected8(0.11%)gastricadenocarcinomas,17(0.23%)dysplasiacases,14(0.19%)hyperplasiacases,52(0.71%)intestinalmetaplasiacases,217(2.97%)inflammatorylesions,141(1.93%)gastriculcers,10(0.14%)atrophicgastritiscases,1,365(18.69%)erosivegastritiscases,and5,957(81.58%)superficialgastritiscasesin7,302patients.Theage(P<0.001),gender(P=0.086),laborintensity(P=0.018)andleekfoodintake(P=0.143)wereidentifiedasindependentpredictivefactorsofGC/premalignantlesionspossibility.Thecorrespondingnomogramexhibitedanareaunderthecurve(AUC)[95%confidenceinterval(95%CI)]of0.82(0.74–0.89)forthemodelinggroupand0.80(0.75–0.85)forthevalidationgroup.Theage(P=0.002),gender(P=0.024),smoking(P=0.002)andleekfoodintake(P=0.039)wereindependentpredictivefactorsofprecursorlesionspossibility.ThecorrespondingnomogramexhibitedanAUC(95%CI)of0.62(0.60–0.65)forthemodelinggroupand0.61(0.59–0.63)forthevalidationgroup.Conclusions:WeidentifiedseveralpotentialassociatedfactorsandprovidedapreclinicalnomogramwiththepotentialtopredictthepossibilityofGC/premalignantandprecursorlesions.

简介：AIMTo分析在眼睛的biomechanical和眼睛的生物测定的数据之间的关联，在健康subjects.METHODSThree上由基于Scheimpflug的设备测量了连续大小用角膜的可视化Scheimpflug技术(CorVis圣)被执行健康眼睛上的设备和10个设备特定的参数被记录。Pentacam导出HR的参数(前面、以后的表面上的角膜的弯曲半径；顶端的pachymetry；角膜的体积；角膜的错误数据；前面的房间的深度，体积和角度)并且从IOLMaster的轴的长度(AL)与10特定的CorVis圣parameters.RESULTSMeasurements被相关在43个志愿者的43只眼睛被进行(年龄61.24楴湯污?H

简介：为uveal黑瘤发现新biomarkers(嗯)由在病人分析浆液peptidomeprofile.METHODSProteomic系列与嗯在操作被分析前后并且与那些相比健康控制。磁性的亲密关系祷告被用来捕获浆液肽和帮助矩阵的激光解吸附作用/电离time-of-flight(MALDI-TOF)质量分光计被用来编49肽的浆液肽profiles.RESULTSA面板差别被表示在之间嗯病人和控制，哪个33肽具有在耐心的组的更高的紧张，16肽具有在控制的更高的紧张组。基于这些潜在的标记的联合使用，有1467和9289.0Da的吝啬的分子的群众的肽提供高敏感(83.3%)，特性(100%)和精确性率(93.0%)一起把黑瘤病人区分开来与健康控制。手术后地6mo指向时间，在外科前表示的许多肽差别的层次显示出病人和控制组之间的没有更多的统计差别。纤维蛋白原链先锋作为潜力被识别嗯markers.CONCLUSIONWe证明了一种方便、快的proteomic技术，亲密关系祷告分离和MALDI-TOF分析与生物信息的软件结合了，便于新奇biomarkers的鉴定为嗯。

简介：Aim:Toinvestigatetheeffectofhome-basedcardiacrehabilitationonfunctionalcapacity,healthbehavior,andriskfactorsinpatientswithacutecoronarysyndromeinChina.Methods:Eightypatientswithacutecoronarysyndromewereenrolledinthisprospectiverandomizedcontrolledstudy.Patientsinthecardiacrehabilitationgroup(n=52)receivedhome-basedcardiacrehabilitationwithaheartmanualandahomeexercisevideofor3monthsandpatientsinthecontrolgroup(n=28)receivedonlyroutinesecondaryprevention.The6-minwalkdistance,laboratorytestresults,healthybehavior(questionnaire),qualityoflife(12-itemShortFormHealthSurvey),anxiety(7-itemGeneralizedAnxietyDisorderQuestionnaire),anddepression(9-itemPatientHealthQuestionnaire)wereevaluatedatthebeginningandaftertreatmentfor3months.Results:Comparedwithbaselinedata,52patientswhoparticipatedincardiacrehabilitationhadlonger6-minwalkdistance(515.26±113.74mvs0.445.30±97.92m,P<0.0002),higherproportionsof“alwaysexercise”(78.26%vs.28%,P<0.05),“alwayslimitfoodwithsugar”(65.22%vs12%,P<0.05),“alwayseatfruits200–400geveryday”(82.61%vs.4%,P<0.05).and“alwayseatvegetables300–500geveryday”(21.74%vs.12%,P<0.06)aftertreatmentfor3months.Thelow-densitylipoproteincholesterolcontrolrate(52.17%vs.28%,P<0.05)andthesystolicbloodpressurecontrolrate(100%vs.68%,P<0.05)werealsosignificantlyincreasedaftertreatmentfor3monthsinthecardiacrehabilitationgroup.Nosignificantincreasewasfoundinthecontrolgroupaftertreatmentfor3months.Nocardiac-eventrelatedtohomeexercisewasreportedinbothgroups.Conclusion:Home-basedcardiacrehabilitationisafeasibleandavailablecardiacrehabilitationmodeinChina.

简介：AconitiLateralisRadixPraeparata(Fuzi)isacommonlyusedtraditionalChinesemedicineinclinicforitspotencyinrestoringyangandrescuingfromcollapse.Aconitialkaloids,mainlyincludingmonoester-diterpenoidaconitines(MDAs)anddiester-diterpenoidaconitines(DDAs),areconsideredtoactasbothbioactiveandtoxicconstituents.Inthepresentstudy,afeasible,economical,andaccurateHPLCmethodforsimultaneousdeterminationofsixalkaloidmarkersusingtheSingleStandardforDeterminationofMulti-Components(SSDMC)methodwasdevelopedandfullyvalidated.Benzoylmesaconinewasusedastheuniquereferencestandard.Thismethodwasprovenasaccurate(recoveryvaryingbetween97.5%-101.8%,RSD<3%),precise(RSD0.63%-2.05%),andlinear(R>0.9999)overtheconcentrationranges,andsubsequentlyappliedtoquantitativeevaluationof62batchesofsamples,amongwhich45batcheswerefromgoodmanufacturingpractice(GMP)facilitiesand17batchesfromthedrugmarket.Thecontentswerethenanalyzedbyprincipalcomponentanalysis(PCA)andhomogeneitytest.ThepresentstudyprovidedvaluableinformationforimprovingthequalitystandardofAconitiLateralisRadixPraeparata.ThedevelopedmethodalsohasthepotentialinanalysisofotherAconitumspecies,suchasAconitumcarmichaelii(preparedparentroot)andAconitumkusnezoffii(preparedroot).

简介：AIMTo由高分辨率的Placido基于磁盘的地形学把测量的重覆性/重制度与一个高分辨率的旋转Scheimpflug照相机的作比较并且在与keratoconus在眼睛测量角膜的力量估计在二台仪器之间的协议并且在situkeratomileusis(LASIK)激光以后.METHODSOne眼睛每经历了的36个keratoconic病人和20个题目LASIK在这未来的观察研究被包括。二个独立检查人在一份随机的订单工作了与两台仪器拿每只眼睛的三大小。四个参数在前面的角膜上被测量：陡峭的角膜散光计(K)，扁平的角膜散光计(Kf)，吝啬的角膜散光计(Km)，和散光(Ks-Kf)。Intra检查人重覆性和内部检查人的重制度被计算在内题目标准差(Sw)评估重覆性(R)，变化(CoV)的系数，和intraclass关联系数(国际计算中心)的系数。在仪器之间的同意被计算.RESULTSInkeratoconic眼睛，intra检查人和内部检查人的国际计算中心是的同意(95%LoA)的95%限制与Bland-Altman方法测试>0.95。作为与由高分辨率的Placido基于磁盘的地形学的测量相比，高分辨率的旋转Scheimpflug照相机的intra检查人R是更低的为Kf(0.32对0.88)，K(0.61对0.88)，和Km(0.32对0.84)但是为Ks-Kf(0.70对0.57)更高。内部检查人的R值为用高分辨率的旋转Scheimpflug照相机测量的所有参数是更低的。95%LoA是到为Kf，到为K的+0.99的-1.36，到为Km的+0.50的-1.08，和到为Ks-Kf的+1.48的-1.11的+0.55的-1.28。在post-LASIK眼睛，intra检查人和内部检查人的国际计算中心是>0.87为所有参数。intra检查人和内部检查人的R为用高分辨率的旋转Scheimpflug照相机测量的所有参数是更低的。intra检查人R为Kf是0.17对0.88，0.21对0.88为K，0.17对0.86为Km，并且0.28对0.33为Ks-Kf。内部检查人的R为Kf是0.09对0.64，0.15对0.56为K，0.09对0.59为Km�

简介：CD8+细胞毒素的T淋巴细胞(CTL)疲劳是为在长期的传染疾病的无效病毒消除的一个主要问题。我们产生了新奇ovalbumin(卵)特定的OVA-Texo和导致治疗学的免疫的HIV特定的Gag-Texo疫苗。在长期的感染估计他们的治疗学的效果，我们由与表示卵的侵入人体气管粘膜的病菌AdVova感染C57BL/6老鼠的i.v开发了一个新长期的感染模型。在长期的AdVova感染期间，老鼠CTL被发现房间死亡protein-1(PD-1)和淋巴细胞激活gene-3(LAG-3)到禁止的分子规划了的快车，证明在T房间增长，IFN-生产和cytolytic的重要缺乏完成机能上地精疲力尽并且。天真的CD8+T房间upregulated禁止的PD-ligand1(PD-L1)，B淋巴细胞和T淋巴细胞衰减器和T房间联系变应力缺乏的分子(圣盘和痒)当时下面调整在在有长期的感染的老鼠的刺激之上的proliferative反应。显著地，OVA-Texo疫苗抵抗了T房间变应力缺乏并且变换了CTL疲劳。后者与(i)被联系为CTL功能的一个标记的upregulation，diacetylatedhistone-H3(diAcH3)，(ii)CTL，宿主DC的发生独立人士或CD4+T细胞的四折的增加，并且(iii)CTLIFN-生产和cytotoxicity的恢复。在vivoOVA-Texo-stimulatedCTLupregulatedmTORC1的活动小径相关的分子Akt，S6，eIF4E和T赌注，和有一个mTORC1禁止者的CTL的处理，rapamycin，显著地在CTL减少了OVA-Texo-induced增加。有趣地，发信号的OVA-Texo-mediatedCD40L在观察免疫学的效果起了一个关键作用。重要地，Gag-Texo疫苗在长期的感染导致了作呕特定的治疗学的免疫。因此，这研究应该为人的免疫不全在新治疗学的疫苗的发展有严肃的影响病毒(HIV-1)感染。