简介：Platinum-basedanticanceragentsarewidelyusedasfirst-linedrugsincancerchemotherapyforvarioussolidtumors.However,greatsideeffectsandoccurrenceofresistanceremainasthemajordrawbacksforalmostalltheplatinumdrugsdeveloped.Toconquertheseproblems,newstrategiesshouldbeadoptedforplatinumdrugbasedchemotherapy.Modernnanotechnologyhasbeenwidelyemployedinthedeliveryofvarioustherapeuticsanddiagnostic.Itprovidesthepossibilityoftargeteddeliveryofacertainanticancerdrugtothetumorsite,whichcouldminimizetoxicityandoptimizethedrugefficacy.Here,inthisreview,wefocusedontherecentprogressinpolymerbaseddrugdeliverysystemsforplatinum-basedcombinationtherapy.

简介：TanshinoneIIAisapharmacologicallyactivecompoundisolatedfromDanshen(Salviamiltiorrhiza),atraditionalChineseherbalmedicineforthemanagementofcardiacdiseasesandotherdisorders.Butitsunderlyingmolecularmechanismsofactionarestillunclear.ThepresentinvestigationutilizedadataminingapproachbasedonnetworkpharmacologytouncoverthepotentialproteintargetsofTanshinoneIIA.Networkpharmacology,anintegratedmultidisciplinarystudy,incorporatessystemsbiology,networkanalysis,connectivity,redundancy,andpleiotropy,providingpowerfulnewtoolsandinsightsintoelucidatingthefinedetailsofdrug-targetinteractions.Inthepresentstudy,twoseparatedrug-targetnetworksforTanshinoneIIAwereconstructedusingtheAgilentLiteratureSearch(ALS)andSTITCH(searchtoolforinteractionsofchemicals)methods.AnalysisoftheALS-constructednetworkrevealedatargetnetworkwithascale-freetopologyandfivetopnodes(proteintargets)correspondingtoFos,Jun,Src,phosphatidylinositol-4,5-bisphosphate3-kinase,catalyticsubunitalpha(PIK3CA),andmitogen-activatedproteinkinasekinase1(MAP2K1),whereasanalysisoftheSTITCH-constructednetworkrevealedthreetopnodescorrespondingtocytochromeP4503A4(CYP3A4),cytochromeP450A1(CYP1A1),andnuclearfactorkappaB1(NFκB1).Thediscrepancieswereprobablyduetothedifferencesinthedivergentcomputerminingtoolsanddatabasesemployedbythetwomethods.However,itisconceivablethatalleightproteinsmediateimportantbiologicalfunctionsofTanshinoneIIA,contributingtoitsoveralldrug-targetnetwork.Inconclusion,thecurrentresultsmayassistindevelopingacomprehensiveunderstandingofthemolecularmechanismsandsignalingpathwaysofinasimple,compact,andvisualmanner.

简介：Risingworldwidecancerincidenceandresistancetocurrentanti-cancerdrugsnecessitatetheneedfornewpharmaceuticalcompoundsanddrugdeliverysystem.Malfunctionoftheimmunesystem,particularlyinthetumormicroenvironment,causestumorgrowthandenhancestumorprogression.Thus,cancerimmunotherapycanbeanappropriateapproachtoprovokethesystemicimmunesystemtocombattumorexpansion.Texosomes,whichareendogenousnanovesiclesreleasedbyalltumorcells,contributetocell-cellcommunicationandmodifythephenotypicfeaturesofrecipientcellsduetothetexosomes'abilitytotransportbiologicalcomponents.Forthisreason,texosome-baseddeliverysystemcanbeavaluablestrategyfortherapeuticpurposes.Toimprovethepharmaceuticalbehaviorofthissystemandtofacilitateitsuseinmedicalapplications,biotechnologyapproachesandmimetictechniqueshavebeenutilized.Inthisreview,wepresentthedevelopmenthistoryoftexosome-baseddeliverysystemsanddiscusstheadvantagesanddisadvantagesofeachsystem.

简介：以处方笺配药和推荐销售一般用医药品为核心大多数的日本连锁药店是依靠大量进货以及以提供折扣实现大量销售得以扩大发展的。但是，随着竞争企业的多门店化发展、以及其他业界企业的参与加入，再加上高龄人口增多而引致的商圈狭小化，