简介：AbstractAntibody-drug conjugates (ADCs) combine the high specificity of monoclonal antibodies with the high anti-tumor activity of small molecular cytotoxic payloads. The anti-tumor activity of ADCs is mainly achieved by the direct blocking of the receptor by monoclonal antibodies, direct action and bystander effect of cytotoxic drugs, and antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity. ADCs have been used in adjuvant therapy and rescue treatment of human epidermal receptor 2 (HER2)-positive breast cancer, greatly improving the prognosis of breast cancer patients. Several ongoing clinical trials of ADC for breast cancer and other solid tumors proved the potential of ADCs will provide more promising treatment options for patients with malignant tumors. This review introduces the mechanism and latest clinical progress of ADC drugs approved for HER2-positive breast cancer to guide clinical practice and conduct research.

简介：Objective-TocomparetheconsistencyoftheresultsfromdetectingHIV-1antibodyinthepairedurineandserumspecimensfromdrugusersbyELISA.Methods:Thepairedurineandserumspecimensfrom273drugusersdetainedatadetoxificationunitwerecollected,andtheHIV-1antibodiesinthespecimensofthemwerescreenedbyurineandserumELISAkits,respectively.Results:Of273serumspecimens,94onesshowedpositivereactionandamong94counterparturinespecimens,93onesalsoappearedpositivereaction.Takingtheresultstogether,theconsistentrateofHIV-1antibodyscreenedbyurineandserumELISAkitswas99.6%.Conclusion:TheurineELISAkit,whichscreenedHIV-1antibodyofurineshowingalmostthesameresultstestedbyserumELISAkit,isreliable.ItisproposedthaturineELISAbeintroducedinmanyfields.

简介：IntroductionThereisnowanewwaytotreathypercholesterolemia,usingamonoclonalantibody(Evolocumab)thatbindstoandinhibitsPCSKA9.MostphysiciansknowthetermPCSK9buthavenoideawhatPCSK9standsfor(includingme).MypurposeforwritingthiseditorialistoeducatemyselfonwhatPCSK9isandwhatitdoes.MyhopeisthatIcanperhapseducatethosereadingthisdocumentaswell.

简介：为非强迫的优化在方法上介绍研究。学习的假设；主要结果；在简化Armijo类型下面的方法的集中性质衬里搜索。

简介：Theconjugategradientmethodforunconstrainedoptimizationproblemsvarieswithascalar.Inthisnote,ageneralconditionconcerningthescalarisgiven,whichensurestheglobalconvergenceofthemethodinthecaseofstrongWolfelinesearches.ItisalsodiscussedhowtousetheresulttoobtaintheconvergenceofthefamousFletcher-Reeves,andPolak-Ribiere-Polyakconjugategradientmethods.Thattheconditioncannotberelaxedinsomesenseismentioned.

简介：Themainpurposeofthispaperistoprovidearestartingdirectionforimprovingonthestandardconjugategradientmethod.Ifadrasticnon-quadraticbehaviouroftheobjectivefunctionisobservedintheneighbourofxk,thenarestartshouldbedone.Thescalingsymmetricrank-oneupdatewithDavidon’soptimalcriterionisappliedtogeneratetherestartingdirection.Itisprovedthattheconjugategradientmethodwiththisstrategyretainsthequadratictermination.Numericalexperimentsshowthatitissuccessful.

简介：为Hamiltonian微分方程的数字处理，symplectic综合者是最合适的选择，并且方法thal是结合一样到symplectic综合者份额好长期的行为。这笔记描绘线性多，方法是其内在的一步舞的步方法结合到一个symplectic综合者。寄生答案部件的围住的海角没被探讨。

简介：Somepropertiesofthepreconditionedgradientconjugatemethodaregiven.Itmayhappenthatlossofsignificantdigits,whenthenormofresidualisverysmall.Toavoidthis,avariantalgorithmwhichdoesnotusetheresidualisputforward.

简介：在这份报纸，我们在存在上解决一个问题结合线性多步方法(LMSM)的symplecticity，否定结果被获得。[从作者抽象]

简介：LetKbearight-continuousandnondecreasingfunction.AfunctionfanalyticintheunitdiskDbelongstothespaceDKifD|f(z)|2K(1-|z|2)dA(z)<∞.DecompositiontheoremsforDKspacesareestablishedinthispaper.Asanapplication,weobtainacharacterizationofinterpolationbyfunctionsinDKspaces.Furthermore,wecharacterizefunctionsinDKspacesbyconjugatepairs.

简介：Thispaperconsidersthefollowingquestion:GivenanAnosovendomorphismfonT~m,whetherfistopologicallyconjugatetosomehyperbolictotalendomorphism?ItiswellknownthattheanswerforAnosovdiffeomorphismsandexpandingendomorphismsisaffirmative.HweverfortheremainderAnosovendomorphisms,aquitedifferentanswerisobtainedinthispaper,i.e.,forgenericAnosovendomorphisms,theyarenottopologicallyconjugatetoanyhyperbolictoralendomorphism.

简介：TheobjectiveofthisstudyistoexploreapotentiallyeffectivetrainingmethodforthehospitalprofessionalstoeducatedrugusersandtoenhancetheirknowledgeofHIVinfection.Onehundredandsixtyonesubjects,whocamefrom13differentprovincesandwereadmittedinadrugreliefhospitalinBeijing,wererecruitedforthisstudy.Theaverageageofthesesubjectswas35.21±6.24yearold.Theaveragenumbersofyearsfordrugaddictionwere7years,andtheaveragenumbersofdrugrelieftreatmentreceivedinthepastwas5.5times.ThelevelofAIDSknowledgeofthesesubjects,includingpathogenicfactors,sourceofinfection,routeoftransmissionandpreventivemeasures,wereevaluatedbeforeandafterreceivingtheAIDSeducationaltrainingtothesedrugusers.Ourresultsshowedthattherewasastatisticallysignificantincrease(P＜0.01)intheknowledgeofHIVinfectionandpreventionamongthesesubjects.PositiveattitudeandbehavioraltendenciestowardHIVpreventionwerealsoimproved.Therefore,itisimperativeforthemedicalprofessionalstoincorporateAIDSeducationintodrugrelieftreatmenttoachievethemaximumeffectontheknowledgeofAIDSandimprovementofpositiveattitudesandbehaviorstowardHIVpreventionamongdrugusers.

简介：Drugdevelopmentinoncologyisundergoingasubstantialshiftnowadays.Thedriversforthisaremulti-factorial.Ontheoneside,drugdevelopmentisperformedmorerationallythanever,profitingfromthescientificadvancesinmolecularbiologyingeneralandtheelucidationofthevarious'omes'fromgenometometabolomeinparticular.Ontheotherside,itisbasedonenormoustechnologicalprogress,e.g.,inthefieldofgenome

简介：人被自然选择进化到目前在自然生物圈中的地位，因故人的生命是坚强的。于是，作为自然的主宰，人创造了许多是自然原本没有的“东西”，这些人为的“东西”既给纯朴的自然描绘上了华丽的色彩，同时也给自然带来了不少的灾难，源于这些灾难，人的生命随时随地都可能发生“差错”，这又折射出人生命的脆弱。为了保护自己，人便创造了医学，也发明了药物，以便能在这许许多多的“差错”之中拯救人的生命于危验。

简介：

简介：Inthispaperweconsidertheglobalconvergenceofanyconjugategradientmethodoftheformd1=-g1,dk+1=-gk+1+βkdk(k≥1)withanyβksatisfyingsumeconditions,andwiththestrongwolfelinesearchconditions.Undertheconvexassumptionontheobjectivefunction,weprevethedescenfpropertyandtheglobalconvergenceofthismethod.

简介：Thispaperderivesfirstordernecessaryandsufficientconditionsforunconstrainedconed.c.Programmingproblemswheretheunderlinedspaceispartiallyorderedwithrespecttoacone.Theseconditionsaregivenintermsofdirectionalderivativesandsubdifferentialsofthecomponentfunctions.Moreover,conjugatedualityforconed.c.Optimizationisdiscussedandweakdualitytheoremisprovedinamoregeneralpartiallyorderedlineartopologicalvectorspace(generalizingtheresultsin[11]).

简介：preconditioned结合坡度deconvolution方法联合稀少的deconvolution和最佳的preconditioned的实现结合坡度方法转换到思考系数。这个方法能提高地震数据处理的频率并且拓宽有效频率带宽。就地震信号的变化时间的性质而言，我们在deconvolution期间用多尺度的变化时间的小浪代替经常的小浪。数字测试证明这个方法能获得好申请结果。

简介：APRP-typesmoothingconjugategradientmethodforsolvinglargescalenonlinearcomplementarityproblems(NCP(F))isproposed.Ateachiteration,twoArmijolinesearchesareperformed,whichguaranteesthepositivepropertyofthesmoothingparameterandminimizesthemeritfunctionformedbyFischer-Burmeisterfunction,respectively.GlobalconvergenceisstudiedwhenF:R~n→R~nisacontinuouslydifferentiableP_0+R_0function.Numericalresultsshowthatthemethodisefficient.

简介：这研究的目的是评估各种各样的格子的潜力令人满意地模仿一部冷却电影的发展，用考虑完整的几何学的acoupled计算。30度的单个排的详细计算在一个扁平的盘子上绕行洞为吹0.764，1.01和1.54的比率被介绍。模拟结果与试验性的数据被作比较很好。二层的模型给了更精确的结果，但是比标准墙工作的消费了更计算的时间。有有y+的适当的值的墙函数的k-蔚骚乱模型对实际使用合适。结果为精确地在冷却电影以内描述热转移的影响显示出conjugate计算的重要性。关键词拍摄冷却-结合热转移-刮的比率CLC数字TK124