简介:ThehugewinterstormofDecember23–29,2015deliveredheavyrainfallinabroadswathacrosstheUSA,delugingEast-CentralMissouri.Recordhighriverlevelsweresetatmanysites,butdamagesweremostpronouncedindevelopedfloodplainareas,particularlywherehighleveeswerebuiltorriverchannelsgreatlynarrowed.Anaverageof20cmofrainthatmostlyfellinthreedaysimpactedtheentire10300km2MeramecBasin.Comparedtothepriorrecordfloodof1982,thehighestrelativestage(+1.3m)onMeramecRiveroccurredatValleyParkproximalto(1)anewlevee,(2)alandfillinthefloodway,(3)largefloodplainconstructionfills,and(4)tributarycreekbasinsimpactedbysuburbansprawl.Eventhoughonlyasmallfractionofthe1.8millionkm2MississippiRiverwatershedaboveSt.Louisreceivedextraordinaryrainfallduringthisevent,thehugechannelizedrivernearandbelowSt.Louisrapidlyrosetosetthe3rd-highesttothehigheststagesever,exhibitingtheflashyresponsetypicalofamuchsmallerriver.
简介:2015年是极不平凡的一年,广大基层民警在各自岗位上经历了许多血与火的考验、苦与累的煎熬,或英勇、或悲壮,或喜悦、或感伤,或惊心动魄、或平淡无奇……无论喜怒哀乐,都值得回味和总结。想倾吐的话可能很多,请选择其中最难忘、最具纪念意义的一件事、一段经历或一个故事,写出来与大家一起分享。
简介:1.Generalsituationofrareearthmarket2015isthelastyearofthe"twelfth-fiveyear"andalsothekeyyearto,comprehensivelydeepenreform.AgreatprogresshasbeenmadeinChina’seconomicsystemreformduringtheperiod.Fromthepointofeconomicoperation,China’sindustrialeconomymadeasteadyprogress.Addedvalueofhigh-techindustryincreasedby10.4%duringthefirstthreequarters,4.2%higherthantheoverallindustrialgrowthrate.
简介:Livertransplantation(LT)isalife-savingtreatmentforpatientswithend-stageliverdiseaseandforpatientswithlivercellcancerrelatedtoliverdisease.Acuteandchronicliverdiseasesrelatedtohepatitisvirusesarebetweenthemainindicationsforlivertransplantation.Theriskofviralreinfectionaftertransplantationisthemainlimitingfactorintheseindications.Beforetheavailabilityofantiviralprophylaxis,hepatitisBvirus(HBV)recurrencewasuniversalinpatientswhowereHBVDNA-positivebeforetransplantation.ThenaturalhistoryofrecurrentHBVwasacceleratedbyimmunosuppression,anditprogressedrapidlytograftfailureanddeath.Introductionofpost-transplantprophylaxiswithimmunoglobulinalonefirst,andassociatedtoantiviraldrugslater,drasticallyreducedHBVrecurrence,resultinginexcellentlong-termoutcomes.Onthecontrary,recurrenceofhepatitisCisthemaincauseofgraftlossinmosttransplantprograms.Overall,patientandgraftsurvivalafterLTforhepatitisCvirus(HCV)-associatedcirrhosisisinferiorcomparedwithotherindications.However,successfulpretransplantorposttransplantantiviraltherapyhasbeenassociatedwithincreasedgraftandoverallsurvival.Untilrecently,thecombinationofpegylatedinterferonandribavirinwasthestandardofcareforthetreatmentofpatientswithchronichepatitisC.Highlyactiveantiviralcompoundshavebeendevelopedoverthepastdecade,thankstonewinvitrosystemstostudyHCVentry,replication,assembly,andrelease.