简介：背景：基于主观标准或预言规则，临床医生对预告测验概率的评价对深静脉的血栓(DVT)的诊断中央。为DVT诊断的预告测验概率评价从来没在怀孕女人被评估过。客观：为了为DVT诊断评估临床医生对预告测验概率的主观评价的精确性并且识别预言变量，那能与怀疑的DVT在怀孕女人被用于预告测验概率评价。设计：代表性的研究进行了超过7年(到2007年4月的2000年3月)。设定：在加拿大的5个加盟大学的、第三级的照顾中心。病人：194unselected怀孕女人与怀疑了第一DVT。干预：DVT的诊断在表示或在连续成像上与反常压缩ultrasonography被建立。由主观评价的预告测验概率被血栓专家在结果的知识前为每个病人记录。大小：主观预告测验概率评价的敏感，特性，否定预兆的价值，和可能性比率并且他们的相应95%CI根据DVT的诊断被计算。病人们是DVT积极如果他们在后续上在起始或连续的严峻或征兆的静脉的thromboembolism有诊断压缩ultrasonography。病人们是DVT否定如果他们在后续上在表示和没有静脉的thromboembolism有否定压缩ultrasonography。估计DVT的一条预言规则被导出，并且内部确认研究被做探索它的表演。结果：DVT的流行是8.8%。临床医生对预告测验概率的主观评价把病人分成了2个组：有DVT的低流行的低预告测验概率(三分之二个病人)(1.5%[95%CI，0.4%～5.4%])并且98.5%的否定预兆的价值(CI，94.6%～99.6%)，并且有DVT的更高的流行的非低的预告测验概率(24.6%[CI，15.5%～36.7%])。三个变量(在左腿的症状[L]，小牛圆周差别2厘米[E]，并且第一个三个月演讲[英尺])在怀孕病人的DVT是高度预兆的。限制：很少结果发生了。总的来说，17个事件在学习期间被诊断。导出的预言规则应该在把它用于临床的实践前在一件独立样品�

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简介：Theadenomatoidodontogenictumorischaracterizedbytheformationofduct-likestructuresandappearanceofeosinophilicmaterials.Eosinophilicmaterialsshowamorphousmassordropletsamongtheepithelialcells.Intheduct-likestructures,itshowsathinlayerofbasementmembranel...

简介：Eosinophiliculceroforalmucosa(EUOM)isanonspecificclinicalappearance,whichappearstobefrequentlyunrecognizedormisdiagnosedusuallyassquamouscellcarcinoma(SCC),especiallyinoldpatients.Itisarareself-limitedbenignulcerativedisease,anditischaracterizedwiththeinfiltrationofeosinophilicleukocytesmixedwithotherinflammatorycells,1,2suchasthemitoticallyactivelargemononuclearcellswithroundorovoidpalenucleus.Thiscelltype,ofteninterpretedasahistiocyte,confoundsthehistologicevaluationandoccasionallyleadstotheerroneousdiagnosisoflymphohistiocyticmalignantcondition.Althoughithasassumedthattraumaisanimportantetiologicfactor,theexactpathogenesisremainsunclear.3ThemorbidityofthisdiseaseislowandtherearefewChineseliteraturesaboutit,4soitisnecessarytopaymoreattentiontoit.Inthisarticle,3outof5casesofEUOMaremisdiagnosedasSCC,andwewillreporttherecordsinordertoidentifyitfromSCCwell.

简介：AbstractBackground:The eosinophilic chronic obstructive pulmonary disease (COPD) is known to be more sensitive to corticosteroid. The sputum microbiome has been shown to affect COPD prognosis, but its role in acute exacerbations of eosinophilic COPD is unclear. This study aimed to investigate the dynamic changes of the airway microbiome in patients with acute exacerbations of eosinophilic COPD.Methods:Fifty-seven patients with acute exacerbations of COPD from the First Affiliated Hospital of Guangxi Medical University between June 2017 and June 2018 were divided into two groups. Patients with eosinophils ≥300 cells/μL in the peripheral venous blood were assigned to the eosinophilic group (Eos) and the rest to the non-eosinophilic group (Noneos). All patients received similar treatment including inhaled budesonide according to the guidelines. The induced sputum microbiome was analyzed on the 1st and 7th day of treatment using the 16S ribosomal RNA (rRNA) method. The levels of interleukin (IL)-6 and IL-8 were measured in the plasma and the sensitivity to corticosteroids was determined in isolated peripheral blood mononuclear cells. Quantitative data were compared between the two groups using the independent samples t test or Mann-Whitney U test. Categorical data were evaluated using Chi-squared test or Fisher’s exact test.Results:Twenty-six patients were classified into Eos group and 31 patients were classified into Noneos group. Prior to treatment, the alpha diversity (Shannon index) (2.65 ± 0.63 vs. 2.56 ± 0.54, t = 0.328, P = 0.747) and the structure of the sputum microbiome were similar in the Eos group and the Noneos group. After 7 days of treatment, alpha diversity increased in both groups, while the microbiome richness (Ace index) was significantly lower in the Eos group (561.87 ± 109.13 vs. 767.88 ± 148.48, t = -3.535, P = 0.002). At the same time, IL-6 (12.09 ± 2.85 pg/mL vs. 15.54 ± 2.45 pg/mL, t = -4.913, P < 0.001) and IL-8 (63.64 ± 21.69 pg/mL vs. 78.97 ± 17.13 pg/mL, t = -2.981, P = 0.004) decreased more significantly in the Eos group, and the percentages of inhibition of IL-8 at dexamethasone concentrations 10-8 to 10-6 mol/L were significantly higher in the Eos group than those in the Noneos group (all P < 0.05).Conclusions:The induced sputum microbiome richness decreased more significantly following treatment in the Eos patients compared to the Noneos patients. The lower plasma inflammatory factor levels and the higher percentage of inhibition of IL-8 might be due to higher corticosteroid sensitivity in Eos patients.

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