简介：ThisstudywasperformedtoassesswhetherthereisanassociationbetweenelevatedFastingBloodGlucose(FBG)andhearingimpairmentinBangladeshipopulation.Atotalof142subjects(72withelevatedFBG;70control)wereincludedinthestudy.Themeanauditorythresholdsofthecontrolsubjectsat1,4,8and12kHzfrequencieswere6.35±0.35,10.07±0.91,27.57±1.82,51.28±3.01dBSPL(decibelsoundpressurelevel),respectivelyandthatofthesubjectswithelevatedFBGwere8.33±0.66,14.37±1.14,38.96±2.23,and71.11±2.96dB,respectively.TheauditorythresholdsofthesubjectswithelevatedFBGweresignificantly(p<0.05)higherthanthecontrolsubjectsatalltheabovefrequencies,althoughhearingimpairmentwasmostevidentlyobservedatanextra-high(12kHz)frequency.Subjectswithalongdurationofdiabetes(>10years)showedsignificantly(p<0.05)higherlevelofauditorythresholdsat8and12kHz,butnotat1and4kHzfrequencies,comparedtosubjectswithshorterdurationofdiabetes(
10years).Inaddition,basedonthedataofoddsratio,moreacuteimpairmentofhearingattheextra-highfrequencywasobservedindiabeticsubjectsofbotholder(>40years)andyounger(
40years)agegroupscomparedtotherespectivecontrols.Thebinarylogisticregressionanalysisshoweda5.79-foldincreaseintheoddsofextra-highfrequencyhearingimpairmentindiabeticsubjectsafteradjustmentforage,genderandBMI.Thisstudyprovidesconclusiveevidencethatauditorythresholdatanextra-highfrequencycouldbeasensitivemarkerforhearingimpairmentindiabeticsubjects.

简介：Theparameteridentificationmodeloflargescalechromatographyseparationprocessisproposed.ThephaseequilibriumconstantsandlumpedmasstransfercoefficientsofsugarandreducingsugaradsorptiononD1,D2andD3resinsaswellastheaxialdispersioncoefficientsofthefluidthroughpackedcolumnsaredeterminedbymeansofthepulse-responseexperimenttechniquewithaninertsubstanceasatracerandthechromatographymeasuringtechnique.Theelutioncurvecalculatedfromtheseparametersisgoodagreementwiththeexperimentalelutioncurve.Thesensitivityanalysisoftheseparametersiscarriedout,andtheresultshowsthattheelutioncurvesofchromatographyseparationaremoresensitivetothevariationsofthephaseequilibriumrelationshipthantothevariationoftheaxialdispersionaswellasthelumpedmasstransfercoefficients.

简介：吃糖一向被视为肥胖者的大忌，除此以外，一般读者可能还知道吃糖与蛀牙、与某些心血管疾病的关系。可你是否想到过吃糖与人的衰老也有关系呢？相信读过此文会另你大长见识。

简介：

简介：AbstractObjective:Rubicon is an inhibitory interacting protein of the autophagy-related protein Uvrag. We previously showed that Rubicon deficiency promotes autophagic flux in vivo and that autophagy can degrade lipid droplets. This study aimed to investigate the effects of Rubicon deficiency on fasting-induced hepatic steatosis.Methods:Two-month-old wild-type (WT) and Rubicon-deficient mice were subjected to feeding or fasting for 24 hours to induce hepatic steatosis. The distribution of liver lipid droplets was revealed by oil red O staining. Hepatic and plasma triglyceride, non-esterified fatty acid (NEFA), and cholesterol levels were detected using commercially available kits. Real-time reverse transcriptasepolymerase chain reaction was performed to analyze the mRNA expression of genes related to lipid metabolism in the liver. Western blot was conducted to assess autophagy-related protein levels in the liver. The animal experiments were approved by the Institutional Animal Care and Use Committee at Shanghai Jiao Tong University, China.Results:We showed that under fasting conditions, Rubicon-deficient mice had more lipid droplets in the liver than WT controls. Consistent with these results, the hepatic triglyceride, NEFA, and cholesterol levels in fasted Rubicon-deficient mice were significantly higher than those of fasted WT controls. The levels of SREBP-1, a key regulator of lipid synthesis, were significantly lower in livers from fasted WT mice than those of fed WT mice. However, the decrease in SREBP-1 in fasted mice was attenuated by Rubicon deficiency. Western blot analysis demonstrated that the fasting-induced increase in autophagic flux was amplified by Rubicon deficiency. Finally, we showed that Rubicon deficiency in mice led to elevated plasma triglyceride and NEFA acid levels under fasting conditions.Conclusion:Rubicon deficiency exacerbates fasting-induced hepatic steatosis in mice.

简介：

简介：Tostudytheeffectofthesugarchainsinglycoalkaloidsagainstcancercells,6-O-sulfatedsolamargineandacid-catalyzedhydrolyticproductsofα-solamargineandα-solasoninewereprepared.ThesulfationatO-6ofsolamarginewasproceededinfivesteps.The6-OHgroupwasfirstselectivelyprotectedwithDMT-Cl,andthenthesecondaryhydroxylgroupsonthesugarringwereacetylated.AftertheprotectivegroupDMTrwasremoved,thefree6-OHgroupwassulfated.Finally,theacetylgroupswereremovedtogive6-O-sulfatedsolamargineinagoodyield.Thehydrolysesofsolamargineandsolasoninewereperformedindilutedhydrogenchlorede.Threeandtwohydrolyzedproductswereobtainedfromsolamargineandsolasonine,respectively.TheantiproliferativeactivitiesagainstHCT-8tumorcellsoftwoglycoalkaloidsandtheirderivatieswereexaminedviaaMTTassay.Theresultsshowthatα-solamargineandα-solasonineexhibitstrongcytotoxicactivitieswithanIC50of10.63and11.97μmol/L,respectively,wherastheirderivatiesseemtobelessactivities.

简介：AbstractObjective:This article aimed to compare the peripheral blood flow intensity (BFI) in the maternal right and left kidney in uncomplicated third trimester pregnancies and to study possible associations between parenchymal BFI in the kidneys and maternal, labor and new-born characteristics.Methods:We conducted a prospective cohort study in third trimester pregnancies at Trondheim University Hospital, Norway, from January to April 2018. The BFI in the maternal kidneys was examined with color Doppler ultrasound and the peripheral BFI was calculated using the Pixel Flux-method which is a method based on pixel wise calculation of color in an image. Velocity was coded by the color bar in the ultrasound device. The peripheral BFI was calculated as the product of velocity and area encoded by all colored pixels divided by all pixels within the cortical layer by a software examining the color in each pixel of a standardized region of interest of the renal parenchyma in video-clips through a complete heart cycle. BFI (cm/s) was thus calculated as follows:The primary outcome measure was peripheral BFI in the renal cortex. We also examined associations between BFI in the entire cortex with maternal age, body mass index, blood pressure, pH in the umbilical artery, Apgar score after 5 minutes and birthweight.Results:In all, 51 pregnant women were included in the study, but 17 were excluded, mainly due to movement artifacts from the pulsating aorta, leaving 34 women in the final study population. We found significantly lower BFI in the cortex of the left kidney compared with the right kidney, 0.37 cm/s versus 0.69 cm/s, respectively (P = 0.04). Dividing into regions, the BFI was significantly lower in the proximal 25% of the left renal cortex compared to the corresponding right side (P= 0.01), and in the proximal 50% cortex (P= 0.02), but the differences were not significantly different in the distal 25% (P= 0.06) or in the distal 50% (P= 0.20) of the renal cortex.We observed a significant negative correlation between peripheral BFI in the left kidney and both systolic blood pressure (r = -0.38; P= 0.03) and diastolic blood pressure (r= -0.36; P= 0.04), and no significant correlations between BFI with maternal age, body mass index, blood pressure, pH in the umbilical artery, Apgar score after 5 minutes and birthweight in the left kidney (P > 0.05). We did not observe any significant correlations between BFI in the right kidney and maternal or new-born characteristics (P > 0.05).Conclusion:The BFI in the left renal cortex was lower compared with the right renal cortex, and BFI in the left renal cortex was negatively correlated with blood pressure, but not significantly correlated with maternal age, body mass index or newborn characteristics. We did not observe any significant correlations between BFI in the right kidney and maternal or new-born characteristics.

简介：无

简介：

简介：Ultrasonicbiophysicistsandphysicianshavecontinuouslyexhibitedgreatinterestinstudyingtheultrasonicpropertiesofblood.Itisshownthatcompressibilityofredcellappearstobeinverselypropor-tionalwithitshemoglobincontent.Amongultrasonicattenuationproducedbyredcellstructurelevelinblood,absorptionofredcellplayspredominantrole,viscousrelativemotionlossaccountsforlessthan15%,andcellscatteringcontributionisnegligible.Thecoagulationprocessofbloodisaccompaniedbysignificantchangeofsoundparameters.Themarkedadvantagehasbeenfoundintestofbloodcoagula-tionprocessbyusingultrasonictechniquethanthetraditionalviscousmethod.Bloodcoagulationcausessoundattenuation,soundbackscatteringandnonlinearityparameterB/Atoincrease,buttheattenuationfrequencydependencehardlychanges.Allofthesefindingsareofanimportantrealisticsignifi-cancefordevelopingultrasonicmedicine.

简介：

简介：

简介：

简介：Itisveryimportanttomaintainthelevelofmeanarterialpressure(MAP).TheMAPcontrolisappliedinmanyclinicalsituations,includinglimitingbleedingduringcardiacsurgeryandpromotinghealingforpatient'spost-surgery.Thispaperpresentsafuzzycontroller-basedmultiple-modeladaptivecontrolsystemforpostoperativebloodpressuremanagement.Multiple-modeladaptivecontrol(MMAC)algorithmisusedtoidentifythepatientmodel,anditisafeasiblesystemidentificationmethodeveninthepresenceoflargenoise.Fuzzycontrol(FC)methodisusedtodesigncontrollerbank.Eachfuzzycontrollerinthecontrollerbankisinfactanonlinearproportional-integral(PI)controller,whoseproportionalgainandintegralgainareadjustedcontinuouslyaccordingtoerrorandrateofchangeoferroroftheplantoutput,resultinginbetterdynamicandstablecontrolperformancethantheregularPIcontroller,especiallywhenanonlinearprocessisinvolved.Fordemonstration,anonlinear,pulsatile-flowpatientmodelisusedforsimulation,andtheresultsshowthattheadaptivecontrolsystemcaneffectivelyhandlethechangesinpatient'sdynamicsandprovidesatisfactoryperformanceinregulationofbloodpressureofhypertensionpatients.

简介：Thispaperpresentsthedevelopmentofthebloodflowsimulationintwodimensionsovertherealgeometryofthefemoralartery.TheNavier-Stokesequationsaresolvedusingthefiniteelementmethod,toobtainthedistributionsofthebloodpressureandflowvelocityinmultipleinstantsoftimeanddifferentplacesofthefemoralarteryandthusdeterminethecurrentconditionofthebloodvessels.Thevelocityfieldshowsalaminarbehavior,where,thevelocityishigherinthecenterofthearteryanddecreasesasthebloodflowapproachesarterywalls.Inspiteofallarteryandbloodflowpropertiesnotbeingconsidered,thevaluesofpressureandvelocityobtainedarewithinthenormalranges.Finallythemodelisusedtoverifyifthereexistirregularitiesinthebloodflowinbothhealthysubjectsandsickpatients.

简介：Onthebasisofthemedicalandmechanicalanalysisandexplanationsinthispaperthevisco-elasticsimplysupportedbeammodelisproposedtotreatthedisplacementwaveofthebloodvessels.Therelationshipsbetweenthedisplacementwaveandbloodvesselelasticityaswellastheviscousdissipationofthebloodandbloodvesselareobtained.ThecorrespondingrelationsofsuchkindsofpulsesinthetraditionalChinesemedicineassmoothpulse,surfacepulseanddeeppulsetothedisplacementwavesofbloodvesselsarealsofound.Thecomputationalresultsareingoodagreementwiththoseacquiredintheexperimentswithultrasonicwave.

简介：

简介：Thereexistmanymethodstomeasurebloodspeed,allofwhichhavesomeseriousshortcomings.Asfiberischaracterisedbytinydiameter,andlowlostratioofpowerandflexibility,itissuitableformeasuringbloodspeed.Itisprovedthatthespeedometerhashighspaceresolvingpower,hightimeresolvingpower,andoutstandingcapabilityofapproachingtarget,etc.

简介：无