简介：AbstractBackground:Endotoxin tolerance (ET) is a protective phenomenon in which pre-treatment with a tolerance dose of lipopolysaccharide (LPS) leads to dramatically elevated survival. Accumulating evidence has shown that peripheral T cells contribute to the induction of ET. However, what happens to T cell development in the thymus under ET conditions remains unclear. The purpose of this study was to analyze the alterations in thymocyte populations (double-positive [DP] and single-positive [SP] cells) under ET conditions.Methods:Mice were intraperitoneally injected with LPS at a concentration of 5 mg/kg to establish an LPS tolerance model and were divided into two groups: a group examined 72 h after LPS injection (72-h group) and a group examined 8 days after LPS injection (8-day group). Injection of phosphate-buffered saline was used as a control (control group). Changes in thymus weight, cell counts, and morphology were detected in the three groups. Moreover, surface molecules such as CD4, CD8, CD44, CD69, and CD62L were analyzed using flow cytometry. Furthermore, proliferation, apoptosis, cytokine production, and extracellular signal-regulated kinase (ERK) pathway signaling were analyzed in thymocyte populations. The polymorphism and length of the T-cell receptor (TCR) β chain complementarity-determining region 3 (CDR3) were analyzed using capillary electrophoresis DNA laser scanning analysis (ABI 3730).Results:Thymus weight and cell counts were decreased in the early stage but recovered by the late stage in a murine model of LPS-induced ET. Moreover, the proportions of DP cells (control: 72.130 ± 4.074, 72-h: 10.600 ± 3.517, 8-day: 84.770 ± 2.228), CD4+ SP cells (control: 15.770 ± 4.419, 72-h: 44.670 ± 3.089, 8-day: 6.367 ± 0.513), and CD8+ SP cells (control: 7.000 ± 1.916, 72-h: 34.030 ± 3.850, 8-day: 5.133 ± 0.647) were obviously different at different stages of ET. The polymorphism and length of TCR β chain CDR3 also changed obviously, indicating the occurrence of TCR rearrangement and thymocyte diversification. Further analysis showed that the expression of surface molecules, including CD44, CD69, and CD62L, on thymocyte populations (DP and SP cells) were changed to different degrees. Finally, the proliferation, apoptosis, cytokine production, and ERK pathway signaling of thymocyte populations were changed significantly.Conclusion:These data reveal that alterations in thymocyte populations might contribute to the establishment of ET.

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简介：摘要:目的：探究放射性131碘对甲状腺功能亢进的治疗效果。方法：108例甲状腺功能亢进患者，随机平分为对比组、I131组。对比TSH、FT3和FT4水平、疗效和不良反应情况。结果：在TSH水平上，对比组（0.27±0.10）mU/L

简介：【摘要】目的：探究在甲状腺功能亢进症治疗中应用柴胡疏肝散加味辅助治疗方法对FT3,FT4及TSH水平的影响。方法：2020.1-2020.12，80例甲状腺功能亢进患者，随机分组法，每组40例。甲巯咪唑片治疗法用于对照组，柴胡疏肝散加味治疗法用于观察组。结果：治疗前两组甲状腺激素水平对比无差异（P＞0.05）；治疗后，观察组TSH水平高于对照组，FT3、FT4水平低于对照组，临床治疗有效率高于对照组（P＜0.05）。结论：在甲状腺功能亢进症疾病治疗中应用柴胡疏肝散加味辅助治疗临床治疗效果显著。

简介：摘要：香烟生产制造中，香精香料是基础原料，对这些原料进行质量控制，才能提高香烟产品的品质。文章从香烟生产中的电气自动控制技术入手，指出香精香料品质的影响因素，阐述了FT-NIR技术在品质控制中的应用，以供参考。

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简介：摘要目的探讨青年缺血性卒中急性期患者血清胆红素、游离三碘甲状腺原氨酸(FT3)水平变化及其临床意义。方法抽取2015年3月至2019年3月郑州大学第一附属医院收治的青年急性缺血性脑卒中患者100例为病例组，另抽取同期健康体检者100例为对照组。回顾性比较两组胆红素和FT3水平，病例组胆红素、FT3水平与患者出入院美国国立卫生研究院卒中量表(NIHSS)评分(预后评估)的关系行Pearson分析。结果病例组总胆红素、直接胆红素、间接胆红素及FT3水平低于对照组(t＝-8.718、-3.192、-8.320、-8.281，P<0.05)。Pearson分析结果显示，总胆红素、直接胆红素、间接胆红素、FT3水平与入院NIHSS评分均呈负相关(r＝-0.793、-0.222、-0.269、-0.531，P<0.05)，总胆红素、FT3水平与出入院NIHSS评分差值呈正相关(r＝0.833、0.500，P<0.05)。结论青年缺血性卒中急性期胆红素和FT3水平降低，其降低程度可提示患者病情严重程度及短期预后情况。

简介：摘要：语音通信交换系统（Voice communication switching system）简称内话系统，是民航空中交通管理所使用的一种专用语音交换设备。在前级接入无线电甚高频/高频设备、各类电话设备、网络传输设备，集成后为管制部门提供地/地和地/空综合性的通信保障服务，业内俗称内话系统。本文对新疆乌鲁木齐空管中心使用奥地利飞坤公司生产的Frequentis 3020X Rel. 7.1 语音通信交换系统进行介绍，结合多年系统运行使用过程中出现的特殊案例现象进行详细分析，以期对业内同类设备的维护工作提供借鉴。