简介：AbstractBackground:Brain arteriovenous malformations (BAVMs) are abnormal vessels that are apt to rupture, causing life-threatening intracranial hemorrhage (ICH). The estimated prevalence of BAVMs is 0.05% among otherwise healthy individuals. In this study, we aim to investigate the mutational spectrum of syndromic genes in sporadic BAVM.Methods:We recruited a cohort of 150 patients with BAVM and performed whole-exome sequencing on their peripheral blood DNA. To explore the mutational spectrum of syndromic genes in sporadic brain arteriovenous malformation, we selected six genes according to the Online Mendelian Inheritance in Man (OMIM) and literature. All variants in the six candidate genes were extracted and underwent filtering for qualifying variants.Results:There are a total of four patients with rare variants in hereditary hemorrhagic telangiectasia-related genes. In addition, we identified two patients have the variant of RASA1 gene in our database, which are also rare mutations that are absent from population databases. However, we did not find any patients with GNAQ mutations in our database.Conclusions:In conclusion, we demonstrated that variants in syndromic vascular malformations play important roles in the etiology of sporadic BAVM.

简介：Inubiquitouscomputing,datashouldbeabletobeaccessedfromanylocation,andthecorrectnessofdatabecomesvitalduringthecommunication.Supposethatmanyuserssigndifferentmessagesrespectively,beforeforwardingorsendingthesemessages,thentheverifiermustspendalotofcomputingtimetoverifytheirsignatures.Consequently,theaggregatesignatureschemeisaneffectivemethodofimprovingefficiencyinthiskindofsystems,whichprovidestheconveniencefortheverifier.Inthispaper,weproposeanewcertificatelessaggregatesignatureschemewhichisefficientingeneratingasignatureandverification.ThisschemeisprovablysecureundertheextendedcomputationalDiffie-Hellmanassumption.

简介：Quantumalgorithmsbringgreatchallengestoclassicalpublickeycryptosystems,whichmakescryptosystemsbasedonnon-commutativealgebraicsystemshoptopic.Thebraidgroups,whicharenon-commutative,haveattractedmuchattentionasanewplatformforconstructingquantumattack-resistantcryptosystems.Aringsignatureschemeisproposedbasedonthedifficultyoftherootextractionproblemoverbraidgroups,whichcanresistexistentialforgeryagainsttheadaptivelycho-sen-messageattackundertherandomoraclemodel.

简介：多代理签名是一位原来的签名人托付签署能力到一个代理组的一个计划。在计划，仅仅在代理组的所有代理签名人的合作能代表原来的签名人创造签名。Jin和皮脂腺囊瘤第一定义无证书的多代理签名(CLMPS)的正式安全模型并且建议了一个具体CLMPS计划。然而，他们的构造有三个问题：加强的安全模型的定义是不精密的，具体签名计划有一个安全缺陷，并且安全的证明是有瑕疵的。与进一步的考虑，一个补救加强的安全模型被重新定义，并且一个改进计划是也存在地求婚了，它是unforgeable对适应地，选择保证，选择消息和选择身份在随机的神谕攻击。处于这个条件，计算Diffie-Hellman(CDH)假设被用来为我们的CLMPS计划证明安全完整。

简介：Digitalsignatureisoneofthemostimportantcryptographicprimitives.WeproposedanewdigitalsignatureschemebasedonCatalano’strapdoor.SinceCatalano’strapdoorismoreefficientthanexistingtrapdoorsinnumbertheory,ourschemeneednotmodularexponentiationbutseveralmodularmultiplicationsinthesigningalgorithm.Wealsoprovedourschemeisprovablysecureagainstadap-tivelychosenmessageattackbyusingtheForkinglemma.

简介：Aggregatesignaturesareausefulprimitivewhichallowsaggregatingmanysignaturesondifferentmessagescomputedbydifferentusersintoasingleandconstant-lengthsignatureandadaptstoMobileAdhocNETwork(MANETs)verymuch.JuminSong,etal.presentedanID-basedaggregatesignature,appliedittoMANETsandproposedasecureroutingscheme.Inthiswork,weanalyzeJuminSong,etal.’saggregatesignatureschemeandfindsomelimitationsonitsbatchverification.Inaddition,inthiswork,weapplyCraigGentry,etal.’sID-basedaggregatesignaturetoon-demandroutingpro-tocoltopresentasecureroutingscheme.Ourschemenotonlyprovidessoundauthenticationandasecureroutingprotocolinadhocnetworks,butalsomeetsthenatureofMANETs.

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简介：Thenumberofcompletelysequencedarchaealgenomeshasbeensufficientforalarge-scalebioinformaticstudy.Wehaveconductedanalysesforeachcodingregionfrom36archaealgenomesusingtheoriginalCGSalgorithmbycalculatingthetotalGCcontent(G+C),GCcontentinfirst,secondandthirdcodonpositionsaswellasinfourfoldandtwofolddegeneratedsitesfromthirdcodonpositions,levelsofargininecodonusage(Arg2:AGA/G;Arg4:CGX),levelsofaminoacidusageandtheentropyofaminoacidcontentdistribution.InarchaealgenomeswithstrongGCpressure,arginineiscodedpreferablybyGC-richArg4codons,whereasinmostofarchaealgenomeswithG+C<0.6,arginineiscodedpreferablybyAT-richArg2codons.InthegenomeofHaloquadratumwalsbyi,whichiscloselyrelatedtoGC-richarchaea,GCcontenthasdecreasedmostlyinthirdcodonpositions,whileArg4>>Arg2biasstillpersists.Proteomesofarchaealspeciescarrycharacteristicaminoacidbiases:levelsofisoleucineandlysineareelevated,whilelevelsofalanine,histidine,glutamineandcytosinearerelativelydecreased.NumerousgenomicandproteomicbiasesobservedcanbeexplainedbythehypothesisofpreviouslyexistedstrongmutationalATpressureinthecommonpredecessorofallarchaea.

简介：Inthispaperanewsignaturescheme,calledPolicy-EndorsingAttribute-BasedSignature,isdevelopedtocorrespondwiththeexistingCiphertext-PolicyAttribute-BasedEncryption.Thissignatureprovidesapolicy-and-endorsementmechanism.Inthismechanismasingleuser,whoseattributessatisfythepredicate,endorsesthemessage.Thissignatureallowsthesignertoannouncehisendorsementusinganaccesspolicywithouthavingtorevealtheidentityofthesigner.Thesecurityofthissignature,selflessanonymityandexistentialunforgeability,isbasedontheStrongDiffie-HellmanassumptionandtheDecisionLinearassumptioninbilinearmapgroups.

简介：阀值签名起一个重要作用在现代电子社会散布一个单个权威的力量。以便增加功能并且改进阀值签名的效率，有签署当局区分的一个多政策阀值签名计划被建议。在计划，二个组能签名并且验证对方，因此计划是双向的签名并且验证。而且，二个组的阀值价值能随着签名文件的安全分类变化，每个自由签署者仅仅签署这个文件的小部分而不是整个的，为组签名建设的数据传播的带宽能因此被减少，组签名的尺寸等价于任何单个签名的。

简介：Inthispaper,asecureandincidentaldistortiontolerantsignaturemethodforimageauthenticationisproposed.ThegenerationofauthenticationsignatureisbasedonHotelling'sT-squareStatistic(HTS)viaPrincipalComponentAnalysis(PCA)ofblockDCTcoefficients.HTSvaluesofallblocksconstructauniqueandstable'block-edgeimage',i.e.,StructuralandStatisticalSignature(SSS).ThecharacteristicofSSSisthatitisshort,andcantoleratecontent-preservingmanipulationswhilekeepingsensitivetocontent-changingattacks,andlocatetamperingeasily.Duringsignaturematching,theFishercriterionisusedtoobtainoptimalthresholdforautomaticallyanduniversallydistinguishingincidentalmanipulationsfrommaliciousattacks.Moreover,thesecurityofSSSisachievedbyencryptionoftheDCTcoefficientswithchaoticsequencesbeforePCA.Experimentsshowthatthenovelmethodiseffectiveforauthentication.

简介：ＳｔｒｏｎｇＳｉｇｎａｔｕｒｅＤｅｐｅｎｄｅｎｃｅｏｆＹｒａｓｔＬｅｖｅｌｓｉｎ１６２Ｌｕ￥ＺｈａｎｇＹｕｈｕ；ＺｈｏｕＸｉａｏｈｏｎｇ；ＺｈａｏＱｉｎｇｚｈｏｎｇ；ＳｕｎＸｉａｎｇｆｕ；ＬｅｉＸｉａｎｇｇｕｏ；ＧｕｏＹｉｎｇｘｉａ?..

简介：TherootsofPaeoniaelactifloraPall.arewidelyconsumedascrudedrugsinAsiancountriesduetotheirremarkablebeneficialhealtheffects.Thepresentresearchwasundertakentoilluminatethedynamicchangesinmetabolitesandenzymesandfacilitateselectionoftheharvestingtimewhentheherbcanprovideoptimumhealthbenefits.P.lactiflorarootswereanalyzedat12stagesofgrowthformonoterpenoidglycosides,phenols,nucleosides,nucleobases,aminoacids,andpolysaccharidesbyhigh-performanceliquidchromatographywithphotodiodearraydetector,ultra-highpressureliquidchromatographycoupledwithtandemmassspectrometry,andUVspectrophotometry.Theenzymeactivitiesofplantβ-glucosidasesandesterasesweredeterminedbyUVmethods.ThetotalcontentofmonoterpenoidglycosidesandphenolspeakedinDecember.Fornucleosidesandnucleobases,thehighestcontentappearedinApril.ThemaximumphasicaccumulationofthetotalaminoacidstookplaceinMarch,andthecontentoftotalpolysaccharidesreachedapeakvalueinSeptember.December,April,andMarchwereselectedastheappropriateharvestingtimesforproducingnaturalmedicinalorhealthfoodproducts.Plantβ-glucosidasesandesterasesshowedthehighestactivityinDecemberandMay,respectively.Whentheactivityofβ-glucosidaseincreased,esteraseactivitydecreased,whilethecontentsofoxypaeonifloraandpaeoniflorinincreased.Whenesteraseactivityincreased,thecontentsofbenzoylpaeoniflorin,paeoniflorin,andgallicaciddecreased.Inconclusion,theresultsfromthepresentstudywouldbeusefulindeterminationofthesuitabletimeforharvestingP.lactiflorarootsformedicinalpurposes.

简介：时装是我们与自己的对话的方式，我们用经验与直觉去创作与表达所想，TONGLISIGNATURE2017秋冬系列所探究的，是“当下”与“自我”的双重关系。

简介：Inthispaper,weputforwardaweakblindquantumsignatureschemebasedonquantumentanglementswappingofBellstates.Differentfromtheexistingquantumsignatureschemes,ourschemecanoffertwo-stepverificationsecurityservicestoensurethevalidityoftheverification.Inordertoguaranteetheunconditionalsecurityofthescheme,thequantumkeydistributionprotocolandone-timepadencryptionalgorithmareemployedinourscheme.Besides,theentanglementswappingofBellstatesmechanismenhancesthesecurityofverificationcriteria.Theproposedschemehasthepropertiesofnonforgeability,nonrepudiation,lindness,andtraceability.

简介：SignatureDiamond极具艺术气息的靓丽外形是其最夺目之处．它的外形出自英国著名的工业设计师KennethGrange之手．SignatureDiamond的箱体是椭圆造型．采用多层夹板制造．内部同样设有Matrix矩阵加强结构。SignatureDiamond箱体顶端是一块倾斜的金属板，上面安放着用产自意大利的大理石制造的高音单元腔体．纯天然的花纹绝不会出现重复．因此每一只SignatureDiamond音箱都可谓是独一无二。

简介：Twosignaturesystemsbasedonsmartcardsandfingerprintfeaturesareproposed.Inonesignaturesystem,thecryptographickeyisstoredinthesmartcardandisonlyaccessiblewhenthesigner'sextractedfingerprintfeaturesmatchhisstoredtemplate.Toresistbeingtamperedonpublicchannel,theuser'smessageandthesignedmessageareencryptedbythesigner'spublickeyandtheuser'spublickey,respectively.Intheothersignaturesystem,thekeysaregeneratedbycombiningthesigner'sfingerprintfeatures,checkbits,andarememberablekey,andtherearenomatchingprocessandkeysstoredonthesmartcard.Additionally,thereisgenerallymorethanonepublickeyinthissystem,thatis,thereexistsomepseudopublickeysexceptarealone.

简介：Electronictransactionthroughe-paymentprotocolwillgrowtremendousinthecomingyears.Inthisarticle,byconverselyusingblindsignature,theauthorsproposeafairelectronicpaymentschemeforelectroniccommerce,whichcanensuretwoparticipants’rightsimultaneouslyinelectronictransactionprocess.Thisschemeisdifferentfromotherexistingschemesanditdoesnotrequirestrongtrustrelationbetweencustomerandmerchant.Inthescheme,asemi-trustedthirdparty(S-TTP)isinvolvedtoprovideafaircommerceenvironment.TheS-TTPtakespartintheprotocolon-lineandnosecureinformationaboutthebusinessisleaked.Moreover,theparticipantsdonotneedtoregistertoS-TTP.Thisschemedoesnotrequireinterventionofathirdpartyincaseofdispute,ifoneusercheatsorsimplycrashes.

简介：蛋白质领域被保存，在相互作用起一个重要作用在之中的机能上地独立的结构联系了蛋白质。域域相互作用最近被用来预言蛋白质蛋白质相互作用(PPI)。一般来说，一双领域的相互作用概率用训练得分功能被获得。令人满意阀值，当“交往”，带那些领域的蛋白质对被考虑。在这研究，蛋白质的签名内容被利用在Saccharomycescerevisiae，Caenorhabditiselegin，和人预言PPI对现代人。蛋白质签名模式的类似被获得，PPI预言基于二进制类似得分函数被拉。结果证明由建议途径的预言的真积极的率用最大的可能性评价方法比那高是约32%，导致在与一个测试集合相比操作的接收装置下面的区域的22%增加什么时候特征(巨鸟)曲线。当包含一个或二签名的蛋白质被移开时，预言的PPI对的敏感显著地增加了。预言的PPI对是平均，11更多半预定在0.95的信心水平比随机的选择交往，并且平均，4比那些由也预言更好预定种系发生的介绍或基因表达介绍。

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