简介：Background:Depressiondisordercoexistsinchronicdiseaseswithsomaticdiseasesandhashighmorbidity,disabilityandmortality.Currentresearcheshaveconfirmedthatdepressionmaybecausedbycoronaryheartdisease,hypertensionandheartfailure.Meanwhile,cardiovasculardiseasesmaycauseorworsendepression,leadingtoprolongedhospitalizationandcomplications.

简介：你的睡眠质量如何？是否有夜黑被噩梦惊醒的时候？科学研究证发现，我们正睡眠时，眼球仍然在迅速移动，那么这就表明你正在做梦，REM睡眠到底是怎么一回事？它与我们的大脑神经有何联系？相信读完下面的短文后，你就会找到答案的。

简介：γ-Aminobutyricacid(GABA)isamajorneurotransmitterandplaysimportantrolesinboththedevelopingandmaturecentralnervoussystem(CNS).OnewaythatGABAcanactisbybindingtofast,ionotropicGABAAreceptorsinneurons.ThebindingofGABAtoGABAAreceptorscausesaconformationalchangethatopensionchannels,

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简介：Studiesonbrain-evokedpotentialandcontingentnegativevariation(CNV)inmooddisorderremaincontroversial.Todate,noCNVdifferencebetweenunipolarandbipolardepressionhasbeenreported.Brain-evokedpotentialsweremeasuredinthepresentstudytoanalyzeCNVinthreesubtypesofmooddisorder(mania,unipolardepression,andbipolardepression),andtheseresultswerecomparedwithnormalcontrols.Inthemaniagroup,CNVamplitudeBwasgreaterthanincontrols,andthedepressiongroupexhibitedlowerCNVamplitudeBandsmallerA-S'2area,andprolongedpost-imperativenegativevariationlatency.TheCNVcomparisonbetweenunipolarandbipolardepressionfoundthattheprolongedpost-imperativenegativevariationlatencywasonlyinunipolardepression.Theseresultssuggestthatprolongedpost-imperativenegativevariationlatencyisacharacteristicofunipolardepression,andCNVamplitudechangeisastatecharacteristicofmooddisorderpatients.

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简介：Thestudyofneuronalplasticityunderpathologicalconditionsisnowamajorpointoffocusonthefieldofneurologicalrecovery.Aftertherepeatedfailureofacuteneuroprotectionstrategiesforstroketreatment,thedesignofstudiesaimedatpromotingthereconstructionofneuronalnetworkshasbecomeessential.Methodsforthedeliveryoftherapeuticagentsonasteadydosage,thuspreventingpharmacologicalpeaksorexcessivemanipulationofexperimentalanimals,arethusrequired.Additionally,methodsthatallowthevisualizationofneurologicalremodelingprocessesarefundamentaltotheunderstandingofhowatherapeuticagentexertsitsfunction.Herewedescribehowtheuseofminiosmoticpumpsforthesteadydeliveryofsuchagents,togetherwithtracttracerinjections,canbecombinedtounveilimportantinformationonhowthebrainchangesafterstrokeandhowtherapeuticagentspromotebrainremodelingrecovery.

简介：Strokeisaleadingcauseofdeathanddisabilityinadultsworldwide.Fordecades,theprimaryapproachandgoaloftherapyforstrokehasfocusedonneuroprotection,namelytreatingtheinjuredtissue,withinterventionsdesignedtoreducethevolumeofcerebralinfarction.Enormouseffortinthelaboratoryhasbeendevotedtothedevelopmentof

简介：ObjectiveToreportoutcomesofcochlearimplantation(CI)inachildwithauditoryneuropathyspectrumdisorder(ANSD)andtoprovidepreliminaryclinicalevidenceoftheefficacyofCIinANSDpatients.MethodsA4-year-oldboywithdiagnosedauditoryneuropathyspectrumdisorder(ANSD)receivedimplantationofaNucleusCI24Rafteranunsatisfactorytrialofamplification.Post-implantationperformanceinbothhearingsensitivityandspeechrecognitionwasassessedindifferentsessions.Aidedhearingthresholdsweretestedbybehavioralaudiometry.MandarinEarlySpeechPerceptionTest(MESP),MeaningfulAuditoryIntegrationScale(MAIS),categoryofauditoryperformance(CAP)andSpeechIntelligibilityRating(SIR)wereusedtoassessthebenefitsinauditoryskillsorspeechrecognitiontheboyobtainedfromCI.Thetestswereadministeredbeforesurgeryandat3monthsand7monthsafteropening.ResultsTheboydemonstratedimprovedauditorysensitivitybyusingCI.Concerningspeechrecognitionandcommunication,bothspeechaudiometryandquestionnairesshowedanobviousbenefitfromCI.ConclusionsCIhasworkedefficientlyinthisANSDboy.ButbecauseoflimitedunderstandingofANSDandrehabilitationeffectbycochlearimplantationinthiscondition,theclinicaldecisiontoimplantshouldbecautiousandonlyafterathoroughevaluation.Meanwhile,wellcontrolledandlongtermstudiesareneededtoconfirmtheefficacyofcochlearimplantationinpatientswithANSD.

简介：针刺内关．足三里．乳根和肩贞穴．温灸膻中．治疗了62例产后缺乳患者。经7次治疗．30例产妇乳汁分泌每天400mL以上．精神饱满；26例乳汁分泌每天250mL左右．需补充牛奶喂养婴儿；6例乳汁分泌无明显改善．挤压双侧乳房极少量乳汁分泌。

简介：Themanagementofneurologicaldisordershavehugeandincreasinghumanandeconomiccosts.Despitethis,thereisascarcityofeffectivetherapeutics,andthereisanextremeurgencyfornewandrealtreatments.Inthisshortreviewweanalyzesomepromisingadvancementsinthesearchofnewbioactivemoleculestargetingneuronalnitricoxidesynthase(nNOS),anenzymedeputedtothebiosynthesisofnitricoxide(NO).Indifferentconditionsofneuronaldamages,thismoleculeisoverproduced,contributingtothepathogenesisandprogressionofneuronaldiseases.TwomainapproachestomodulatenNOSarediscussed:afirstoneconsistinginthedirectinhibitionoftheenzymebymeansofsmallorganicmolecules,whichcanbealsoactiveagainstotherdifferenttargetsinvolvedinsuchdiseases.AsecondsectionisdedicatedtomoleculesabletopreventtheformationoftheternarycomplexN-methyl-D-aspartate(NMDA)-typeglutamatereceptors,postsynapticdensity-95(PSD95)protein-nNOS,whichisnecessarytoactivatethelatterforthebiosynthesisofNO.

简介：Concussion,ormildtraumaticbraininjury,incidencerateshavereachedepidemiclevelsandimpairedposturalcontrolisacardinalsymptom.Thepurposeofthisreviewistoprovideanoverviewofthelinearandnon-linearassessmentsofpost-concussionposturalcontrol.Thecurrentacuteevaluationforconcussionutilizesthesubjectivebalanceerrorscoringsystem(BESS)toassessposturalcontrol.Whilethesensitivityoftheoveralltestbatteryishigh,thesensitivityoftheBESSisunacceptablylowand,withrepeatadministration,isunabletoaccuratelyidentifyrecovery.Sophisticatedmeasuresofposturalcontrol,utilizingtraditionallinearassessments,haveidentifiedimpairmentsinposturalcontrolwellbeyondBESSrecovery.Bothassessmentsofquietstanceandgaithaveidentifiedlingeringimpairmentsforatleast1monthpost-concussion.Recently,theapplicationofnon-linearmetricstoconcussionrecoveryhavebeguntoreceivelimitedattentionwiththemostcommonlyutilizedmetricbeingapproximateentropy(ApEn).ApEn,mostcommonlyinthemedial-lateralplane,hassuccessfullyidentifiedimpairedposturalcontrolintheacutepost-concussiontimeframeevenwhenlinearassessmentsofinstrumentedmeasuresareequivalenttohealthypre-injuryvalues;unfortunatelythesestudieshavenotgonebeyondtheacutephaseofrecovery.Onestudyhasidentifiedlingeringdeficitsinposturalcontrol,utilizingShannonandRenyientropymetrics,whichpersistatleastthroughclinicalrecoveryandreturntoparticipation.Finally,limitedevidencefromtwostudiessuggestthatindividualswithaprevioushistoryofasingleconcussion,evenmonthsoryearsprior,maydisplayalteredApEnmetrics.Overall,non-linearmetricsprovideafertileareaforfuturestudytofurthertheunderstandingofposturalcontrolimpairmentsacutelypost-concussionandaddressthecurrentchallengeofsensitiveidentificationofrecovery.

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简介：由独立介绍混乱的四种基本类型进一个二维的三角形的格子，我们在结果的颤动决定混乱的每种类型的角色集体春天的网络。我们主要担心在波色子山峰和横向的Ioffe-Regel限制之间的波色子山峰和连接的起源。为混乱的所有类型，我们观察波色子山峰和Ioffe-Regel限制的出现。与增加混乱，波色子山峰频率BP,横向的Ioffe-Regel频率红外T,和纵的Ioffe-Regel频率红外L都减少。我们发现有二个方法让波色子山峰形成：发展从并且共存与(但是留下的独立人士)横向的货车胀起奇特没有并且与本地协作数字变化。仅仅当混乱是足够地强壮的并且引起本地协作的空间变化时，面对混乱，红外TBP,和红外TBP的一种单个类型数。而且如果没有位置的混乱，红外T红外L。因此，波色子山峰等价于横向的Ioffe-Regel限制的争论不是一般的。我们的结果两个都建议那本地协作数字和位置的混乱是必要的让争论成立，它实际上是为象在边际地堵塞的固体和结构的眼镜那样的很混乱的固体的盒子。我们进一步联合混乱的二种类型在本地协作数字和格子地点位置引起混乱。产生网络的震动的状态的密度类似于在边际地堵塞的固体的很好。然而，在波色子山峰之间的关系和横向的Ioffe-Regel限制仍然是不定的并且条件依赖者。因此，在混乱的不同类型之间的相互影响是复杂的，并且更多的深入的研究被要求整理它。

简介：Cerebralpalsyisoneoftheimportantfactorsinchildren'sdisability.Patients'seatdysfunctionhasaseriousimpactontheirdailylifeandtheirfamily.However,thereiscurrentlynoeffectivetreatmentforthecerebralpalsyseatdysfunction.So,itisofimportancetosearchanewwaytomakeabreakthrough.Acupuncturehassignificantadvantagesinthetreatmentoffunctionaldisorders.Inthispaper,theliteratureaboutclinicalresearchofacupuncturetreatmentofcerebralpalsyseatdysfunctionaresummarized.Wehavecarriedonthemechanismanalysisofsportsmedicinerespectivelyfromthreeangles,includingtraditionalChinesemedicine,westernmedicineandtraditionalChineseandwesternmedicinecombinedwithsportsmedicine.WeconcludethatacupuncturingacupointsonDumeridian,BeishupointsandJiajipointshassignificanteffectonthefunctionofsittingunablechildrenwithcerebralpalsy,suchasstrengtheningthespleen,tonifyingthekidneyandpromotingYangqiandstimulatingthesensorynerveandsoon.Acupuncturingpointsforthetreatmentofcerebralpalsyprovidesalotofinspirationforhumanphysiologyresearchinthefutureandclinicaltreatmentofneurologicaldiseases.

简介：AbstractIn malaria-endemic regions, people often get exposed to various pathogens simultaneously, generating co-infection scenarios. In such scenarios, overlapping symptoms pose serious diagnostic challenges. The delayed diagnosis may lead to an increase in disease severity and catastrophic events. Recent coronavirus disease 2019 (COVID-19) pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has affected various areas globally, including malaria-endemic regions. The Plasmodium and SARS-CoV-2 co-infection and its effect on health are yet unexplored. We present a case report of a previously healthy, middle-aged individual from the malaria-endemic area who suffered SARS-CoV-2 and Plasmodium falciparum co-infection. The patient developed severe disease indications in a short time period. The patient showed neurological symptoms, altered hematological as well as liver-test parameters, and subsequent death in a narrow time span. We hereby discuss the various aspects of this case regarding treatment and hematological parameters. Further, we have put forward perspectives related to the mechanism behind severity and neurological symptoms in this fatal parasite-virus co-infection case. In malaria-endemic regions, due to overlapping symptoms, suspected COVID-19 patients should also be monitored for diagnosis of malaria without any delay. The SARS-CoV-2 and Plasmodium co-infection could increase the disease severity in a short time span. In treatment, dexamethasone may not help in severe cases having malaria as well as COVID-19 positive status and needs further exploration.

简介：Clinicaloutcomesarepositivelyassociatedwithhematomaabsorption.Themonocyte-macrophagescavengerreceptor,CD163,playsanimportantroleinthemetabolismofhemoglobin,andasolubleformofCD163ispresentinplasmaandothertissuefluids;therefore,wespeculatedthatserumCD163affectshematomaabsorptionafterintracerebralhemorrhage.Patientswithintracerebralhemorrhageweredividedintohigh-andlow-levelgroupsaccordingtotheaverageCD163level(1,977.79±832.91ng/mL).Comparedwiththehigh-levelgroup,thelow-levelgrouphadasignificantlyslowerhematomaabsorptionrate,andsignificantlyincreasedNationalInstitutesofHealthStrokeScalescoresandmodifiedRankinScalescores.TheseresultssuggestthatCD163promoteshematomaabsorptionandtherecoveryofneurologicalfunctioninpatientswithintracerebralhemorrhage.

简介：目的：观察疏肝理气、清心除烦中药结合针刺治疗广泛性焦虑症的疗效。方法：治疗组用针刺结合中药治疗40例，对照组采用口服多虑平治疗38例，治疗前、中、后均作焦虑自评量表（SAS）、副反应量表（TESS）评定。结果：治疗组与对照组总有效率分别为82．5％和84．2％，两组治疗前后SAS组内比较差异有统计学意义（P〈0．01），两组间痊愈显效率、总有效率及SAS评分比较无差异（P〉0．05），但副反应对照组显著高于治疗组（P〈0．01）。结论：针刺结合中药治疗广泛性焦虑症疗效确切，且毒副反应轻微。