简介:Thatdaywehadanexam,andIfailed.Feelingsodepressed,Isetasidemylessonsandlookedoutofthewindow,hopingtofindacomfort.Tomygreatjoy,whatabeautifulduskIsaw!Rosycloudscoveredthewholeskyandeverythingseemedsopeaceful.Thesceneremindedmeofmyfriends,bringingmebacktothetimewhenwestudiedtogetherthreeyearsago.
简介:Theintroductionofdesigneroestrogensasatreatmentmedalityinhormonereplacementinwomenhasinvitedtoconsidertheconceptofcompoundswithselectiveandrogeniceffectsformalehonnonereplacementtherapy.Thefullspectrumoftheactionsoftestosteronemaynotbenecessaryofevenundesiredforcertainindicationsfortestosteronetreatment,Todefineforwhatindicationscertainandrogenicpropertiesaredesiredandundesiredmoreinsightinbasicandrogen(patho)physiologyisrequired.Thereisconvincingevidencethataromatizationofandrogeniccompoundstonestrogensmightbeanadvantageformaintenanceofbonemassanditmightalsomitigatenegativeeffectsofandrogensonbichemicalparametersofcardiovascularrisks:thepotentiallynegativeeffectsofoestmgensonprostatepathologyinageingmenneedsfurtherelucidation.Whiletheroleofdihydro-testosterone(DHT)forthemalesexualdifferentiationandforpubertalsexualmaturationisevident,itsroleinmatureandageingmalesseemslesssignificantormayevenbeharmful.Itis,however,ofnotethatanegativeeffectofDHTonprostatepathophysiolog~iscertainlynotproven.Formalecontraceptionaprogestationalagentwithstrongandrogenicpropertiesmightbeanasset.Formostoftheandrogenicactionsthecriticallevelsofandrogensarenotwellestablished.Thelatterisrelevantsincethelargeamountofandrogenmoleculesrequiredforitsbiologicalactions(ascomparedtooestrogens)isanimpedimentinandrogenreplacementmedalities.Theremayberoomformorebiopotentandrogenssincedeliveryoflargeamountsofandrogenmoleculestothecirculationposesproblemsfurtreatmentmodalities.(AsianJAndro11999Jun;1:21-28)
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简介:AbstractIntroduction:Scarring and non-scarring alopecias have rarely been described to occur together in the same patient. Distinguishing these two different types of alopecia is important as treatment and prognosis can be different.Case presentation:Here, we report the first case of simultaneous alopecia areata (AA) and central centrifugal cicatricial alopecia (CCCA) in a 35-year-old woman. New alopecic patches were noted on her frontal and vertex scalp. Biopsy of the frontal scalp revealed miniaturized hair follicles and dense lymphocytic infiltrate surrounding the hair bulbs, consistent with AA; while biopsy of the vertex scalp revealed decreased hair follicles, perifollicular fibroplasia with eccentric atrophy of the follicular epithelium, and premature desquamation of the inner root sheath at the level of the lower isthmus, consistent with CCCA.Discussion:Proposed mechanisms of these two alopecia types occurring together include loss of immune privilege, genetic predisposition, as well as unknown external factors that trigger an autoimmune lymphocytic response. Most recently, the peptidylarginine deiminase type III gene has been implicated in both diseases. Although treatment options can overlap between the two diseases, treatment response can differ and CCCA tends to have a worse prognosis.Conclusion:Awareness of this concomitant presentation of two alopecic types is important for appropriate treatment and prognostication.
简介:这研究的PurposeThe目的是比较在膝extensors.MethodsSixty的力量和力量上在一样的加速下面在各种各样的频率和振幅设置训练程序的8星期的整个身体的颤动的效果--四个年轻参加者随机与一样的加速(4g)被分到4个组中的1个:高频率和低振幅(n=16,32Hz,1mm)组,中等频率和中等振幅(n=16,18Hz,3mm)组,低频率和高振幅(n=16,3Hz,114mm)组织,并且控制n=16,没有颤动)组。参加者8星期与身体训练经历了的所有集中动态蹲,3个会议结果显示出的week.ResultsThe高频率和低振幅组在等轴的收缩力量和120摥琠?硥浡湩?桷瑥敨?显著地增加了?敭瑮污琠慲湩湩?湩整癲湥楴湯挠湡椠据敲獡?桴?敬敶?景倠?湩礠畯杮朠物獬?瑥潨獤?慳灭敬漠??朠物獬愠敧吗??
简介:TheadoptionoftransradialaccessintheUnitedStatesandinternationallyhasbeengrowingoverthepastfewyears.Inthepopulationofpatientspresentingwithacutecoronarysyndromes,particularlyST-elevationmyocardialinfarction,transradialaccesshasthebenefitoffewervascularandbleedingcomplicationsandlowermortalityratesovertransfemoralaccess.Wewillexaminethecurrentevidencesupportingtransradialaccessforseveralpatientpopulations,includingthosepatientspresentingwithacutecoronarysyndromes.Wewillreviewtheliteratureregardingthelearningcurvefortransradialaccesswithnewoperators,aswellasexperiencedtransfemoraloperatorsnewtotransradialaccess.Finally,wewillinvestigatetheroleoftransradialaccessinsame-daydischargeforstablepatientsundergoingpercutaneouscoronaryintervention.
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简介:AbstractBackground:Gastroparesis is a debilitating medical condition with limited treatment options. Gastric per-oral pyloromyotomy (G-POEM) has emerged as a promising treatment option with remarkable short-term clinical success shown in multiple studies. While the post-procedure protocol is not standardized across many centers, the majority of the centers observes these patients in the hospital after the procedure for monitoring. In this single-center prospective study, we evaluated the safety and feasibility of same day discharge after the G-POEM procedure.Methods:All the patients with refractory gastroparesis undergoing G-POEM from October 2019 to March 2020 were enrolled. A total of 25 patients were enrolled in the procedure. Based on the pre-defined criteria, patients were either discharged on the same day after the procedure or admitted to the hospital for further observation. The patient and procedure-related data were extracted from the chart review. Univariate analysis was performed (chi-squared test) on categorical variables after organizing categorical variables as numeric counts or percentages. The student t test was performed on continuous variables after reporting as mean and standard deviation. For analysis with a smaller sample size, Fisher exact and Mann–Whitney tests were used.Results:A total of 25 patients were enrolled. The technical success of G-POEM was 100% and clinical success was 80% (20/25) at 1-month follow-up. Of the 25 patients, 9 patients (36%) were discharged on the same day according to the procedure from the recovery unit. Of the remaining 16 patients who were admitted to the hospital post-procedure, 10 (40%) were admitted due to procedure-related causes while other admissions were either pre-planned or due to social reasons. The average Charlson comorbidity index was lower in the same day discharge group (P < 0.05). The number of patients requiring double myotomy was higher in the same day discharge group (P < 0.05). The overall complication rate of G-POEM in the study cohort was 12% (3/25) with all complications being mild without any severe adverse events.Conclusion:G-POEM is a safe and effective method of treatment for refractory GP with higher clinical success in short-term follow-up. The same day discharge after G-POEM is safe and feasible in >50% of patients with close periprocedural monitoring.