简介：ＳｉｌｉｃｏｎＰｈｏｔｏｄｉｏｄｅｗｉｔｈＶｅｒｙＳｍａｌＳｅｎｓｉｔｉｖｅＡｒｅａ①ＹＩＮＣｈａｎｇｓｏｎｇ，ＬＩＸｉａｏｊｕｎ（ＷｕｈａｎＵｎｉｖｅｒｓｉｔｙ，Ｗｕｈａｎ４３００７２，ＣＨＮ）Ａｂｓｔｒａｃｔ：ＴｈｅｓｉｌｉｃｏｎＰＮｊｕｎｃｔｉ...

简介：Viaseveraltechniquestomodifysensitivematrixforinhabitingtheleakageoffluorescentindicator,anewstablesensingmaterialformonitoringphosphateshasbeenpreparedandappliedtothemeasurementofphosphatesinartificialseawater.ItisbasedonthereactionofPO3-4withAl(Ⅲ)-Morinthatleadstothefluorescencequenchingofthecompositematrix.AtpHvalue4.0andthesalinityvalue25.0,theresponsetimeofoutputsignalhavingreachedthesteadystateislessthan300seconds.ItscalibrationgraphisgainedintherangeofH2PO-4massconcentrationfrom1.50to7.00μg/mLwiththelimitofdetection(3σ/K)0.02μg/mL.Whenitwasusedtomeasurephosphatesinartificialseawater,therecoveryrangedfrom96.78%to102.09%.Beingstoredunderthepropercondition,themembranesmaintainsensitivefor90-120days,andareabletobeusedfor50-80timeswithindicatorsupplement.

简介：Intramolecularvibrationsoflargemacromoleculesresideintheterahertzrange.Inparticular,proteinvibrationsarecloselyspacedinfrequency,resultinginanearlycontinuousvibrationaldensityofstates.Thisdensityofvibrationsinterfereswiththeidentificationofspecificabsorptionlinesandtheirsubsequentassociationwithspecificfunctionalmotions.Thischallengeiscompoundedwiththeabsorptionbeingdominatedbythesolventandlocalrelaxationalmotions.Astrategyforremovingtheisotropicrelaxationallossandisolatingspecificvibrationsistousealignedsamplesandpolarization-sensitivemeasurements.Here,wedemonstrateatechniquetorapidlyattaintheanisotropicresonantabsorbanceusingterahertztimedomainspectroscopyandaspinningsample.Thetechnique,modulatedorientation-sensitiveterahertzspectroscopy(MOSTS),hasanonzerosignalonlyforanisotropicsamples,asdemonstratedbyacomparisonbetweenasiliconwaferandawiregridpolarizer.Forsucroseandoxalicacidmolecularcrystals,theMOSTSresponseisinagreementwithmodeledresultsfortheintermolecularvibrations.Further,wedemonstratethat,eveninthepresenceofalargerelaxationalbackground,MOSTSisolatesunderlyingvibrationalresonances.

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简介：Byanalogueexperimentofexhaustgas,thesensitivecharacteristicsoftitaniatoair/fuelratiowasinvestigated.Theeffectsofsomeimpuri-tiesontheelectricconductivityofTiO2,thedeviationof（A/F）cfrom（A/F）sinnonequilibriumgassystemandtheself-catalyticoxidationofTiO2wereexplainedrespectively.Theeffectsofca-talyst,porosityandthicknessofsensorelementontheresponsetimewasalsoanalyzed.

简介：Atwo-dimensionalpositionsensitiveparauel-plateavalanchecounter(PPAC)witha100mm×100mmactiveareaisdevelopedfortheRadioactiveIon-BeamLineinLanzhou(RIBLL).ThedetectorconsistsofoneanodeplaneandtwocathodeswireplaneswhicharestripplanesforthePPACsusedinRIKEN~[1].TheanodeisaMylarfoilcoatedwithathinlayerofgoldoneachside.ThecathodeplanesXandYaremadeofgold-

简介：新benzoimidazole-naphthalimide衍生物4被综合，它的photophysical性质被学习。这混合物有选择地高度出现了并且敏感比色并且为氟化物阴离子的ratiometric察觉到能力。

简介：ThesynthesisofanewtypeofX-ray-sensitivecompound'di-(1-hydroxylundecyl)diselenide'anditsapplicationinthepreparationofanewtypeofliposomewithX-raysensitivitywasreported.Thisnewliposomewassynthesizedtoencapsulatedoxorubicinhydrochloride(Dox),withitsphysicalandchemicalproperties,stability,andradiationsensitivitydetermined.BasedonthepH-gradientmethod,liposomalDoxwaspreparedviaultrasonicemulsificationandthenpurifiedonaSephadexG50mini-column.UVspectrophotometryandliquidchromatographywereusedtodetecttheencapsulationefficiencyandradiationsensitivityoftheDox-loadedliposome.Theresultsshowthatthroughchangesinreleaserate,thisliposomeshowsarelativeradiosensitivity.Intermsofradiationsensitivity,thedrugleakrateoftheX-ray-sensitiveDox-loadedliposomeincreasedgraduallyandpeakedat65.4%undertheX-rayradiationofadoseof10Gyormorethan10Gy,whichissignificantlydifferentfromthatofordinaryliposomes.Meanwhile,X-ray-sensitiveDox-loadedliposomehasagooddispersionstability,withanaverageparticlesizeofapproximate120nm.TheefficiencyofthisliposomeencapsulatingDoxwas75.84%,slightlylowerthanthatofordinaryliposomes.TheX-ray-sensitiveDox-loadedliposomeexhibitedsuspensionstabilitywithin30dofstorageat4°C,withoutvisibleprecipitation.Di-(1-hydroxylundecyl)diselenideissafeandnoncytotoxicandcomparedwiththoseofsyntheticphospholipidsitssynthesisislowcostanddoesnotrequirecomplexconditions.

简介：Thesignalprocessingcircuitsofpositionsensitivedetector(PSD)withalternatinglightsourcearepresented.ThemeasuringdeviceofPSDwithalternatinglightsourcecaneffectivelyeliminatetheinterferencemadebylightnoisesignal.

简介：CunanoclusterswereelectrochemicallydepositedonthefilmofaNafion-solubilizedmulti-wallcarbonnanotubes(CNTs)modifiedglassycarbonelectrode(CNTs-GCE),whichfabricatedaCu-CNTscompositesensor(Cu-CNTs-GCE)todetectglucosewithnon-enzyme.Thelinearrangeis7.0×10-7to3.5×10-3mol/Lwithahighsensitivityof17.76μA/(mmolL),withalowdetectionlimit2.1×10-7mol/L,fastresponsetime(within5s),goodreproducibilityandstability.

简介：Non-destructivediagnosticmethodsareveryimportantforbeamadjustmentsandmonitors,especiallywhenthebeamintensityislessthan10~8ppsduringtheheavy-iontreatmentofcancer.NowthediagnosticdevicesofHIFRLcan’tsatisfytherequests,sowedecidetoconstructadetectingsystemoftheresidual-gasbeamprofile~([1,2]).ThesystemusesthePositionSensitiveDetector(PSD)~([3,4])basedonmicrochannelplate(MCP)to

简介：为软织物重建得到一种新支架材料，我们通过混合crosslinked准备了XLHA-PNIPAAm和XLHA-MC血管注射剂hydrogels哈(XLHA)并且二温度敏感的材料poly在降级不同(N-isopropylacrylamide)(PNIPAAm)并且methylcellulose(MC)分别地。我们测试了injectablility，酶的biodegradability，温度敏感，结构cytotoxicity和二血管注射剂hydrogels的溶血。我们的研究成功地获得了XLHA-PNIPAAm血管注射剂hydrogel的准备条件，并且验证了那补充说非可能减解的材料PNIPAAm能推迟降级哈更有效地比可能减解的材料MC。与5kGy剂量放射准备的PNIPAAm，MBAAm/NIPAAm(M/M)=0.015，单体concentration=3%与最慢酶的biodegradability生产了XLHA-PNIPAAm。DSC结果证明XLHA-PNIPAAm的温度敏感比XLHA-MC的更稳定。二合成hydrogels在cytotoxicity和溶血测试被限制，XLHA-PNIPAAmhydrogel的biocompatibility比XLHA-MChydrogel更好出现了。

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简介：AbstractBackground:Despite free diagnosis and treatment for tuberculosis (TB), the costs during treatment impose a significant financial burden on patients and their households. The study sought to identify the determinants for cata-strophic costs among patients with drug-sensitive TB (DSTB) and their households in Kenya.Methods:The data was collected during the 2017 Kenya national patient cost survey from a nationally representative sample (n= 1071). Treatment related costs and productivity losses were estimated. Total costs exceeding 20% of household income were defined as catastrophic and used as the outcome. Multivariable Poisson regression analysis was performed to measure the association between selected individual, household and disease characteristics and occurrence of catastrophic costs. A deterministic sensitivity analysis was carried using different thresholds and the significant predictors were explored.Results:The proportion of catastrophic costs among DSTB patients was 27% (n = 294). Patients with catastrophic costs had higher median productivity losses, 39 h [interquartile range (IQR): 20-104], and total median costs of USD 567 (IQR: 299-1144). The incidence of catastrophic costs had a dose response with household expenditure. The poorest quintile was 6.2 times [95% confidence intervals (CI): 4.0-9.7] more likely to incur catastrophic costs compared to the richest. The prevalence of catastrophic costs decreased with increasing household expenditure quintiles (proportion of catastrophic costs: 59.7%, 32.9%, 23.6%, 15.9%, and 9.5%) from the lowest quintile (Q1) to the highest quintile (Q5). Other determinants included hospitalization: prevalence ratio (PR)= 2.8 (95% CI: 1.8-4.5) and delayed treatment: PR = 1.5 (95% CI: 1.3-1.7). Protective factors included receiving care at a public health facility: PR = 0.8 (95% CI: 0.6-1.0), and a higher body mass index (BMI): PR= 0.97 (95% CI: 0.96-0.98). Pre TB expenditure, hospitalization and BMI were significant predictors in all sensitivity analysis scenarios.Conclusions:There are significant inequities in the occurrence of catastrophic costs. Social protection interventions in addition to existing medical and public health interventions are important to implement for patients most at risk of incurring catastrophic costs.

简介：BasedonLucovskyequation,theresponsesolutionof1-Dpositionsensitivedetector(PSD)isgivenundertheconditionofparallellightobliqueincidenceandGaussianbeamobliqueincidence,andtheresponsecharacteristicsareanalyzedbynumericalcalculation.Therelationbetweenobliqueincidentangleandoutputcurrentisintroducedandillustrated.

简介：Chitosan/，-glycerophosphate(CS/，-GP)当周围的温度增加了时，thermo敏感的hydrogels在低温度和半固体hydrogel介绍了可流动的答案状态。在这研究，metronidazole的不同集中包含了，CS并且，象不同的酸溶剂一样的-GP,，被选择从CS/在药版本行为上评估他们的影响，-GPhydrogels。在一个高原跟随的开始的3h期间有一个支撑的版本，这被发现。SEM图象证明药表面位于并且在hydrogels的内部。为药版本的这hydrogel的最佳的准备条件如下：1.8%(w/v)在HAc溶剂的CS，5.6%(w/v)，-GP和5g/Lmetronidazole封装。Cytotoxicity评估没发现有毒的效果。为了控制版本率，有球形的形状的2.5g/Lchitosanmicrospheres和光滑的表面，被合并，并且起始的版本进程被减轻，这被发现，当药集中没在版本率上有明显的效果时。metronidzole版本行为能根据实际应用被优化，这能被结束。

简介：CHAARTED是在荷尔蒙敏感的前列腺癌症独自除了雄激素剥夺治疗(ADT)对ADT与docetaxel的使用看早化疗的带ECOG的阶段III试用。在与ADT收到了化疗的那些在全面幸存显示出显著改进的试用的积极结果革命化了变形阉割敏感的前列腺癌症的治疗。除了全面幸存，第二等的端点象阉割抵抗的时间那样，PSA反应为收到了早化疗的病人也是重要的。