简介：TheroleplayedbyDNAinmolecularbiologyisclearlyrecognizedtobevitaltolifeonthisplanet.8-oxo-7,8-dihydro-2deoxyguanosine(=8-OHdG),isprobablythemostimportantproductof"oxidativestress”inDNA.ItsconcentrationinDNAis,infact.aquantitativeanalysisofthedegreeofDNAdamagethatanorganismhasundergone.Duetotheimportanceof8-OHdGofnucleicacidginmutagenesis,carcinogenesisandaging,numerouschemicalandbiologicalinvestigationshavebeenmadeonthissubjectinthepasttime.Kuchinoandco-workershavefoundthat8-OHdGresidueinDNAismisreadingduringtheprocessofDNAreplication.Recently,somereportshavebeenpresentedonhigh8-OHdGlevelsinpatientssufferingfromvariousdiseasessuchaschronichepatitis,Fanconisanemia,diabetesmellitusandHelicobacterpyloriinfections.Asaresult,8-OHdGisausefulmarkerforthestudyofDNAdamagearisingfromreactiveoxygenspeciesandisofgreatsignificanceforcancerresearch.The8-OHdGlevelsinDNAcanhelpunderstandthemechanismofcarcinogensandleadtomoreeffectivetreatmentsformanydifferenttypesofcancer.Forthesereasons,ananalysisof8-OHdGwithquickness,lowcostandhighaccuracyisrequired.

简介：5氟尿嘧啶(5-FU)举办许多反肿瘤活动，广泛地适用于癌症的治疗。然而，由于它的狭窄的治疗学的索引在临床的实践决定5-FU的血浆集中是必要的。因此，一个简单、经济、敏感的高效的液体层析(HPLC)方法在人的血浆为5-FU的决心被开发并且验证。乙醇醋酸盐被选择为抽取试剂。色析法的分离在DiamonsilC18列上被执行(250公里獲汥?楷桴琠敨愠獤牯瑰潩?慲楴?楷桴畯?敭桴湡汯

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简介：Aseverythinghasanend,ourliveswillbeoveroneday.Noonecanescape,butwecanchoosethewayofendingourselves.LuYouqinghavelefttheworld,saying."Ihavenoregretallmylife.”Yeah,hewasun-abletochooseliveordiebutdeathisnothingtobeafraidof.Inhislast100days,hewrotedownallhisfeelingswithstrongwill.Weallappreciatehimfortellingusthemeaningoflife

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简介：我们处在一个变幻的时代，面对纷纭复杂的环境，人文，每时每刻都需要我们冷静思考，从容面对，从而更好地驾驶自己的人生，你周围的环境怎么样？是不是有很多倾心、赤诚相待的朋友？读此短篇，或许对你所启迪。

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简介：Theunifiedtheoreticalmomentexpressionsforelutionchromatographyandfrontalchromatographywhenthesorptionprocessisdescribedbyalinearmodelwerederived.Themomentexpressionsderivedbypreviousauthorscanbeobtainedfromtheseunifiedtheoreticalmomentexpressions.Inthispaper,amathematicalanalysishasbeencarriedoutsoastosetupaunifiedtheoreticalbasisforelutionandfrontalchromatography.

简介：Thepresentworkisaimedtostudythepharmacokineticparametersofoptimizedrepaglinidefloatingdrugdeliverysystem(FDDS)by24factorialdesigns,followedbycomparisonwithacommerciallyavailableformulation.Themaineffectsandinteractionsofformulationvariableswerestudiedbyusingnormalandparetocharts.Theoptimizedformulationshowsafickiandiffusiondrugreleasemechanism.Pharmacokineticparametersofthedesigneddrugdeliverysystemwereevaluatedinrabbitmodels.Meanwhileasimple,specifichighperformanceliquidchromatographicmethodwasdevelopedandvalidatedasperbiopharmaceuticalspecifications,thelinearitywasobservedattherangeof110-550ng/mL(r2=0.999).Byusingmethanol-phosphatebuffer(pH2.5)(70:30,v/v)asmobilephaseattheflowrateof1.0mL/minthevalidationshowsabetterretentiontimeof5.2minforrepaglinide.AndthesamevalidationmethodwasusedforpharmacokineticprofileanalysisofrepaglinidemarketedproductsandFDDS.Thecomparativepharmacokineticresultssuchastmax,half-life,areaunderthecurve,meanresidencetimeswereincreasedsignificantlyfortherepaglinideinFDDSthanthemarketedproductofrepaglinideexceptCmaxandeliminationrateconstant.

简介：Lornoxicam(6-chloro-4-hydroxy-2-methyl-N-2-pyridyl-2H-thieno-[2,3-e]-1,2-thiazine-3-carboxamide-1,1-dioxide)ispersistasanon-steroidalanti-inflammatorydrugoftheoxicamclasswithanalgesic,anti-inflammatoryandantipyreticproperties.Afast,accurateandsensitivechromatographicmethodforestimationofLornoxicamwasdevelopedasnoofficialmethodavailablefordetection.ThechromatographicseparationemploysisocraticelutionbyutilizinganinertsilODS-C18,250mm×4.6mm,5μmcolumns.Mobilephaseconsistingofsolvent(40mLacetonitrileand60mL0.1Mphosphatebuffer(pH6.8wasadjustedwithtriethylamine))endowedataflowrateof1.0mL/min.Theanalytewasdetectedandquantifiedat290nmusingUVdetector.ThemethodwasvalidatedaccordingtoICHguidelines,illustratingtobeaccurate(recovery99.08%-101.13%)andprecise(intraday(0.27-1.32)andinterday(0.59-1.59))withinthecorrespondinglinearrange(10-60μg/mL)withr20.9992.

简介：统一穿校服是学校良好风纪的体现，校服也是校园里一道流动的风景。但是最近有些人却认为这样的做法束缚了学生的个性发展，同时，学生们也对呆板的校服深表不满。

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简介：KevinBookoutarrivedattheUniversityofOklahomalastautumnaimingtomaketheOlympicsintheshotputorthediscussomeday.Healsohappenedtoplaybasketball.

简介：如果你留学的方向是美国人文学科或社会学科的博士．那么就来听听美国专家教你如何择校，如何获得名校教授的青睐。

简介：AnHPLCmethodforquantitativedeterminationofadrenalinehydrochlorideinjectionandnoradrenalinebitartrateinjectionwasestablishedandvalidatedwithasubstituteforthereferencesubstance.Phenylephrinehydrochloridewasselectedasthesubstituteforthereferencesubstanceofadrenalineandnoradrenalinebitartrate.Thecorrectionfactorofphenylephrinehydrochloridewithrespecttothereferencesubstanceofadrenalineandnoradrenalinebitartratewasdeterminedunderdefinedconditions.Adrenalinehydrochlorideinjectionandnoradrenalinebitartrateinjectionwerequantifiedbyassayingphenylephrinehydrochlorideandacorrectfactor.TheresultsindicatethattheHPLCmethodwiththesubstituteforreferencesubstancewasreliableandfeasibleforquantitativedeterminationofdrugs.

简介：Istakinganap(小憩)duringthedaygoodorbadforyourhealth?Manypeoplewhooftentakeanaptellusthatitcomeswith1.Firstofall,youaremoreefficient(高效的)afternapping.Yourememberthingsbetterandmake2mistakes.Also,youcanlearnthingsmoreeasilyaftertakinganap.Anapmay3yourself-confidence(自信)andmakeyoumoreactive.Itmayevencheeryouup.Buttherearesomesimple4youshouldfollowabouttakinganap.First,takeanapinthe5oftheday,abouteighthoursafteryouwakeupinthemorning.Next,a20-minutenapisbest.Ifyousleeplonger,youmay6intoadeepsleep.Afterwakingfromadeepsleep,youwillfeelworse.Also,youshouldsetanalarmclock.Thatway,youcanfullyrelax7yournap.Youwon’thavetokeep8theclocksoyoudon’toversleep.

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