简介:AbstractGenomoviridae is a virus family belonging to circular replication associated protein encoding ssDNA (CRESS-DNA) viruses, which have diverse genomic architecture and are widely distributed among different ecosystems. In this study, we characterized 39 novel genomovirus genomes including 3 from wild egrets, 9 from wild cranes, as well as 27 from wild finches in three different types of cloacal swabs of wild bird sampled in the station of Xinqing bird ringing, Maoershan Nature Reserve in Heilongjiang Province, Changbai Mountain in Jilin Province, and Hangzhou Wetland Park in Zhejiang Province, China. Here, using a Rep sequence phylogeny-based analysis, we divided the 39 genomoviruses into 8 genera within the family Genomoviridae, including Gemycircularvirus (n =20), Gemykibivirus (n =3), Gemygorvirus (n =2), Gemyvongvirus (n =2), Gemykolovirus (n =3), Gemykrogvirus (n =6), Gemytondvirus (n=1), Gemyduguivirus (n=1) and one unclassified genomovirus. The 39 genomovirus genomes belong to 36 species (27 of which are new) based on the currently accepted genomovirus pairwise nucleotide sequence identity species demarcation threshold of 78%. Overall, the research enriches our knowledge of CRESS-DNA viral diversity in China and emphasizes the prevalence of genomoviruses in nature.
简介:Wepresentasimulationofthemagnetizationcurves,energy,probability,andtorquelandscapesofuniaxialsystemswithuptofiveanisotropyconstants.ThetotalenergyusedinthesimulationisthesumoftheanisotropyandZeemanenergies.Theexchangeinteractionisnotconsideredinthepresentworkinwhichwetreatsingle-domain-particlesystemswithinaclassicalmechanics-basedmodel.Diversefeaturesofthecalculatedmagnetizationcurvesarehighlightedforthestudiedsystems.Thesediversefeaturesarestronglydependentonthesignandmagnitudeofthesimulationparameters.Themodelisversatileenoughtohandlebothhypotheticalandrealmaterialsystems,e.g.HoFe11TiandY2Co17.
简介:Wolbachia是感染大量节肢动物和丝虫的线虫的细胞内部的共生者。蚜虫从事与他们的endosymbionts的多样、复杂的关系。Wolbachia的四超群(A,B,M和N)以前在蚜虫和超群M被检测,N仅仅在蚜虫被发现。在这研究,我们在中国在蚜虫的自然人口检测了并且描述Wolbachia感染。三超群(A,B和M)在检验蚜虫种类被发现。超群M是优势的,而超群A和B仅仅在某些种类被检测。超群N没在这研究被发现。也就是,有在蚜虫的Wolbachia的四个感染模式有超群M的感染独自一个,有超群A和M,有超群B和M的合作感染,和有超群A,B和M的合作感染的合作感染。仅仅有超群M的感染的模式是通用的并且在所有评估亚科被发现。仅仅二个亚科,Aphidinae和Lachninae,表明了介绍所有四个感染模式。三个模式在Calaphidinae被观察(M,A&M,B&M)并且Eriosomatinae(M,B&M,A&B&M)。二个模式在Anoeciinae被观察(M,A&M)并且Greenideinae(M,B&M),并且一仅仅模式(M)在Aphidoidea的留下的家庭或亚科被观察。这些结果显示在中国蚜虫的Wolbachia感染是普遍的。种系发生的分析建议超群M在中国在蚜虫的所有主人种类之中很快并且最近散布了的那Wolbachia。为这传播和它的机制的原因在他们的蚜虫主人上与Wolbachia的可能的效果一起被讨论。
简介:Wnt-1induciblesignalingpathway-1(WISP-1),alsoknownasCCN-4,belongstotheconnectivetissuegrowthfactor(CTGF)family.WISP-1isprimarilyexpressedinembryonicstemcellsandisinvolvedinadultorgandevelopment.WISP-1participatesinmanycellularprocesses,includingproliferation,differentiation,apoptosisandadhesion.Inaddition,WISP-1playsanimportantroleindiversepathophysiologicalprocesses,suchasembryonicdevelopment,inflammation,injuryrepairsandcancers.RecentstudiesshowedthatWISP-1washighlycorrelatedwithtumorprogressionandmalignanttransformation,whereasitplayedanoncogenicroleincolorectalcancer,cholangiocarcinoma,hepatocellularcarcinomaandbreastcancer.However,interestingly,WISP-1exertsatumorsuppressingroleinlungandprostatecancers.WISP-1promotescellproliferation,adhesion,motility,invasion,metastasisandepithelial-to-mesenchymaltransitionviaparticularsignalingpathways.Inthisreview,wediscussedthestructure,expressionprofile,functions,clinicalsignificanceandpotentialmechanismsofWISP-1incancerandnon-neoplasticdiseases.
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简介:维生素D3起来调整的蛋白质(VDUP1)1是涉及维持细胞的动态平衡的多功能的蛋白质。VDUP1被许多压力导致。相反地,VDUP1经常在各种各样的肿瘤纸巾和房间线被减少。VDUP1的在表示上通过房间周期拘捕禁止房间增长。VDUP1与thioredoxin(Trx)交往并且否定地调整表示和涉及氧化还原作用规定的Trx的抗氧化剂功能。VDUP1-/-鼠标比野类型的鼠标更产生carcinogenesis并且在包括自然漂亮房间的开发和函数建立免疫系统是有缺点的。而且,VDUP1-/-mice表演损害了Kreb调停周期的丰满的酸利用。在这评论,我们在多样的细胞的回答,特别地与增长的它的关系,apoptosis,区别,和象癌症那样的疾病和压力相关的疾病讨论了VDUP1的多功能的角色。
简介:Background:Manytreespeciesintropicalforestshavedistributionstrackinglocalridge-slope-valleytopography.Previousworkina50-haplotinKorupNationalPark,Cameroon,demonstratedthat272species,or63%ofthosetested,weresignificantlyassociatedwithtopography.Methods:Weusedtwocensusesof329,000trees≥1cmdbhtoexaminedemographicvariationatthissitethatwouldaccountforthoseobservedhabitatpreferences.Wetestedtwopredictions.First,withinagiventopographichabitat,speciesspecializingonthathabitat(‘residents')shouldoutperformspeciesthatarespecialistsofotherhabitats(‘foreigners').Second,acrossdifferenttopographichabitats,speciesshouldperformbestinthehabitatonwhichtheyspecialize(‘home')comparedtootherhabitats(‘away').Species'performancewasestimatedusinggrowthandmortalityrates.Results:Inhierarchicalmodelswithspeciesidentityasarandomeffect,wefoundnoevidenceofademographicadvantagetoresidentspecies.Indeed,growthratesweremostoftenhigherforforeignspecies.Similarly,comparisonsofspeciesontheirhomevs.awayhabitatsrevealednosignofaperformanceadvantageonthehomehabitat.Conclusions:Werejectthehypothesisthatspeciesdistributionsalongaridge-valleycatenaatKoruparecausedbyspeciesdifferencesintrees≥1cmdbh.Sincetheremustbeademographiccauseforhabitatspecialization,weofferthreealternatives.First,thedemographicadvantagespecialistshaveathomeoccursatthereproductiveorseedlingstage,insizessmallerthanwecensusintheforestplot.Second,speciesmayhavehigherperformanceontheirpreferredhabitatwhendensityislow,butwhenpopulationbuildsup,therearenegativedensity-dependentfeedbacksthatreduceperformance.Third,demographicfilteringmaybeproducedbyextremeenvironmentalconditionsthatwedidnotobserveduringthecensusinterval.
简介:用树脂分的在结构上多样的bispropargyl醚,quinol,4,4-dihydroxy联本基,bisphenol--A,4,4-dihydroxydiphenyl酉同类,4,4-dihydroxydiphenylsulphone,trimethylindanebisphenol和tetramethylspirobiindanebisphenol被使用阶段转移准备催化剂。综合材料独立在鼹鼠比率(0.5:0.5)与4,4-bismaleimidodiphenyl甲烷(BMIM)被混合。材料热地被治好,结构的描述和这些cross-linked材料的热性质用Fourier变换被调查红外线(FTIR)分光光度计和thermogravimetric分析器(TGA)。在不同材料之中,调查polyMRPE,polyMBPEBPA和polyMSPE显示出300諟?牦的更高的发作降级温度吗?
简介:Environmentalpollutionanddecliningresourcesoffossilfuelsinrecentyears,haveincreaseddemandforbetterfueleconomyandlesspollutionforgroundtransportation.Amongthealternativesolutionsprovidedbyresearchersinrecentdecades,hybridelectricvehiclesconsistedofaninternalcombustionengineandanelectricmotorhavebeenconsideredasapromisingsolutionintheshort-term.Inthepresentstudy,fueleconomycharacteristicsofaparallelhybridelectricvehicleareinvestigatedbyusing...
简介:前列腺癌症是全球癌症相关的死亡的一个领先的原因,但是试图改善诊断并且开发新奇治疗被重要耐心的异质惊讶。在最近的年里,到几百个前列腺瘤的下一代的定序的应用程序定义新奇分子的子类型并且描绘了位于疾病开始和前进下面的广泛的genomic错误。在诊所观察的异质是由与复杂性流行的一处分子的风景的underpinned,现在是清楚的,在genomic重新整理和稀罕变化联合放大transcriptomic差异的地方。这评论把我们前列腺癌症‘的当前的理解;omic的包括拷贝数字变化的哨兵角色,oncogenic熔化基因,chromothripsis的潜在的影响,和在定义联系变化的子类型的突破的成长光谱。增加的证据建议损害经常在特定的细胞的功能和发信号的小径上集成的那genomic,还周期性的基因错误显得稀罕。因此,我们继续定义单个瘤染色体,是批评的,特别在他们的表示transcriptome的上下文。仅仅通过到瘤可变性罐头的瘤的改进描述,我们前进到精确治疗和个性化的肿瘤学的年龄。
简介:Olderadultfallsareasignificantpublichealthproblem,butonethatisamenabletopreventiveinterventions.1,2Despitetheprogressmadeinidentifyingriskfactors,developingefficacioushealth-relatedinterventions,andpromotingevidencebasedprogramsinthecommunity,muchworkremainsbeforethesestrategiesarebroadlyavailableandeffectivelyusedtoreducefall-relatedinjuries.3AsNewtonandScottFindlay4havepointedout,thetranslationofbasicscientificknowledgeintoclinicalstudies,andthetransformationofclinicalstudiesintoimprovementsinhealthservicesandpublichealthpractices,remainmajorobstaclestowidespreadadoption.