简介:摘要现代信息技术的快速发展,给教育事业带来了新的活力。Pad移动终端作为一种新的多媒体技术,它让移动学习成为可能,据此为美术教学开发的软件与日俱增。如何让平板电脑应用在美术教学中,是新时代美术教育应该思考的问题。
简介:摘要目的评估类风湿关节炎(RA)患者中抗PAD2自身抗体(α-PAD2)和抗PAD4自身抗体(α-PAD4)联合检测的临床应用价值。方法本研究收集了2018年11月至2019年11月北京大学人民医院住院的RA患者148例和非RA的关节炎对照(DC组)35例。同时收集了2019年6—7月北京大学人民医院体检的健康体检者44名。通过ELISA方法检测血清中α-PAD2和α-PAD4水平。根据需要,采用Mann-Whitney U检验、Kruskal-Wallis(KW)检验、χ²检验或Fisher精确检验进行统计学分析。相关性分析采用逻辑回归模型。结果α-PAD2和α-PAD4在RA组、DC组及HC组中的阳性率分别为26.4%(39/148)和20.9%(31/148)、5.7%(2/35)和5.7%(2/35)、4.5%(2/44)和2.3%(1/44)。α-PAD4阳性的RA患者较α-PAD4阴性患者病程更长(17.3±13.2年比8.6±10.2年,P<0.001),其肺间质性疾病(ILD)发生率更高(54.8%比25.6%,P=0.002)。α-PAD2与RA-ILD间未发现显著相关(OR:0.797,P=0.579),而α-PAD4与RA-ILD间存在显著相关(OR:3.521,P=0.002)。对于血清阳性的RA患者,α-PAD4抗体仅与RA-ILD呈现弱相关(OR:2.324,P=0.046),而联合检测α-PAD2和α-PAD4,即α-PAD2阴性同时α-PAD4阳性可以显著提高其与RA-ILD的相关性(OR:4.059,P=0.007)。结论α-PAD2存在于RA中,其对于RA的诊断具有一定的潜在价值。此外,α-PAD2联合α-PAD4检测可以增强α-PAD4对于RA-ILD风险的预测价值。因此,α-PAD2作为RA新的潜在生物标志物,可能作为现有RA血清学标志物的重要补充。
简介:Split-stepPadémethodandsplit-stepfouriermethodareappliedtothehigher-ordernonlinearSchrdingerequation.ItisprovedthatacombinationofPadéschemeandspectralmethodisthemosteffectivemethod,whichhasaspectral-likeresolutionandgoodstabilitynature.Inparticular,weproposeanunconditionalstableimplicitPadéschemetosolveoddordernonlinearequations.NumericalresultsdemonstratetheexcellentperformanceofPadéschemesforhighordernonlinearequations.
简介:Thecomputationalproblemsoftwospecialdeterminantsareinvestigated.Thosedeterminantsappearintheconstructionofthefunction-valuedPade-typeapproximationforcomputingFredholmintegralequationofthesecondkind.Themaintooltobeusedinthispaperisthewell-knownSchurcomplementtheorem.
简介:SometribologicalbehaviorbetweenmatureGampsocleisgratiosafootpadsandverticalflatsofdifferentmaterialswerestudiedinthiswork.stereomieroscope(SMS)andscanningelectronmicroscope(SEM)wereusedtomeasurethemorphologyoftheGampsocleisgratiosafootpads.Anatomicforcemicroscope(AFM)wasusedtomeasurethemorphologiesofthesurfacesofglassandawalldopedwithcalciumcarbonatematerial.TheattachingbehaviorofGampsocleisgratiosafeetonthetwoverticalsurfaceswasobserved.Theattachingforce(perpendiculartotheverticalsurface)andthestaticfrictionalforce(alongthedirectionofgravitation)ofGampsocleisgratiosafootpadsonaverticalglassweremeasured.Itwasshownthattheaverageattachingforceis50.59mNandthestaticfrictionalforceis259.10mN.ThephysicalmodelsoftheattachinginterfacebetweenGampsocleisgratiosafootpadsandthetwoverticalsurfaceswereproposed.Itwasobservedthatthefootpadsaresmoothinmacroscale;however,thepadsurfaceiscomposedbyapproximatehexagonalunitswithsizesof3μmto7μminmicroscale;theadjacentunitsareseparatedbynanoscalegrooves.TheObservationsshowedthattheGampsocleisgratiosacannotclimbtheverticalcalciumcarbonatewall;incontrast,theycaneasilyclimbtheverticalglasssurface.Basedonthefeaturesofthegeometricalmorphologiesofthefootpadsandtheglasssurface,wespeculatethattheattachingforceandstrongstaticfrictionalforceareattributedtotheinterinlaysbetweenthedeformableGampsocleisgratiosafootpadsandthenanoscalesharptipsoftheglasssurface.
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