简介：

简介：精索静脉曲张，男不孕的最重要的可对待的原因，是在场的在15%成年男性，有主要不孕的35%人，和有第二等的不孕的80%人。在另一方面，80%这些人不介绍不孕。因此，有需要区分正在施加从“是可对待的有害效果的精索静脉曲张；silent”；精索静脉曲张。尽管有精索静脉曲张的细胞的效果的成长证据，它的内在的分子的机制仍然正在逃避。Proteomics成为了一个有希望的区域决定精液的繁殖生物学以及改进男不孕的诊断。这评论试图与精索静脉曲张在病人在精液的血浆proteomics讨论state-of-art在承担这些研究，以及在精液的proteome上从证据的成长身体导出的未来眼界讨论挑战。

简介：backgroundStudieshavebeeninconsistentregardingwhetherhyperuricemia,eitherdiuretic-ornondiuretic-induced,isanindependentriskfactorforcardiovascularevents.Thestudyinvestigatedtheassociationofcardiovasculardiseasewithdiuretic-andnondiuretic-inducedelevatedserumuricacid.MethodsAcommunity-basedcross-sectionstudywasconductedin5,235treatedanduntreatedhypertensivepatientsaged40-75years.Conventionalriskfactors,serumuricacidandthepresenceofcardiovasculardiseaseweredetermined.Hyperuricemiawasdefinedasserumuricacidlevels≥420μmol/Linmenor≥360μmol/Linwomen.ResultsHyperuricemiawasmorecommoninmenthaninwomen(21.5%vs.10.2%,P<0.001).Afteradjustmentforageandotherconventionalriskfactors,hyperuricemiawasassociatedwithmetabolicsyndrome,decreasedcreatinineclearance,anduseofdiureticsinbothgenders,aswellasageinwomenandalcoholconsumptioninmen.Thepresenceofcoronaryarterydiseaseorstrokeincreasedsignificantlywiththeincreaseofquartilesofserumuricacid(8.0%,11.0%,13.4%,and16.8%,respectively,P<0.01),andthehighestserumuricacidquartilewasassociatedwitha1.8-foldriskforcardiovasculardisease(OR:1.83,95%CI:1.24-2.71)inuntreatedwomen.Butthisassociationwasnotobservedinuntreatedmenaswellasintreatedpatientsusingdiureticsinbothgenders.ConclusionsHyperuricemiaismarkedlyassociatedwithmetabolicsyndrome,decreasedcreatinineclearance,useofdiureticsbesidesalcoholconsumptioninmenandageinwomen.Elevatedserumuricacid,butnotthatdiuretic-induced,maybeassociatedwithincreasedtheriskofcardiovasculardiseaseinuntreatedhypertensivewomen.