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简介：作家走廊中国偶像杰斯·罗著汪雨申邵灵译

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简介：北京、上海、广州，原本是各大汽车厂商划定的一线市场城市名单，现在成了汽车限购城市目录

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简介：Quantumkeydistribution(QKD)isamajorresearchtopicbecauseitprovidesunconditionalsecurity.Unfortunately,manyimperfectionsremaininQKD’sexperimentalrealization.TheFaraday–Michelson(FM)QKDsystemisproposedtoeliminatetheseimperfectionsusingpolarization.However,thelongarm’sphasemodulator(PM)hasanunexpectedinsertionloss,meaningthatthestatesentisnolongerperfect.Inthisletter,weproposeanalternativeFM-QKDsystemstructure,andanalyzethesecurityandkeygenerationrateincomparisonwiththeoriginalsystemviadifferentanalysismethods.WefindanobviouskeyrateimprovementwhenthePMinsertionlossisnotextremelysmall.

简介：AbstractMucormycosis is a lethal human disease caused by fungi of the order Mucorales. Mucormycosis is caused by fungi mainly belonging to the genera Mucor, Rhizopus, and Lichtheimia, all of which belong to the order Mucorales. The number of individuals with mucormycosis-causing disorders has increased in recent years, hence, leading to the spread of mucormycosis. Throughout the coronavirus disease 2019 (COVID-19) pandemic, numerous cases of mucormycosis in COVID-19-infected patients have been reported worldwide, and the illness is now recognized as COVID-19-associated mucormycosis, with most of the cases being reported from India. Immunocompromised patients such as those with bone marrow sickness and uncontrolled diabetes are at a greater risk of developing mucormycosis. Genes, pathways, and other mechanisms have been studied in Mucorales, demonstrating a direct link between virulence and prospective therapeutic and diagnostic targets. This review discusses several proteins such as high-affinity iron permease (FTR1), calcineurin, spore coat protein (CotH), and ADP-ribosylation factors involved in the pathogenesis of mucormycosis that might prove to be viable target(s) for the development of novel diagnostic and therapeutic methods.

简介：Toaddressthephenomenonofsparkingduringtheedgeinductionheatingprocessinhotstripmills,thispaperusesnumericalsimulationtosystematicallyinvestigatethekeyfactorsinfluencingsparkingandtheireffects.Thedistributionofinducedcurrentdensityinthesteelplateaboverollerconveyortableduringtheheatingprocessiscalculatedandcomparedunderdifferentconditions,includingtherelativepositionsofthesteelplateandinductioncoil,thewidthofthesteelplate,andchangesinload.Theresultsshowthatwhenanarrowsteelplateisheatedorthesteelplateshiftstothesideoftheinductioncoil,sparkingbetweenthesteelplateandrollerconveyorismorelikelytooccur.

简介：AbstractBackground:The End Tuberculosis (TB) Strategy of the World Health Organization highlights the need for patient-centered care and social protection measures that alleviate the financial hardships faced by many TB patients. In China, TB treatments are paid for by earmarked government funds, social health insurance, medical assistance for the poor, and out-of-pocket payments from patients. As part of Phase III of the China-Gates TB project, this paper introduces multi-source financing of TB treatment in the three provinces of China and analyzes the challenges of moving towards universal coverage and its implications of multi-sectoral engagement for TB care.Main text:The new financing policies for TB treatment in the three provinces include increased reimbursement for TB outpatient care, linkage of TB treatment with local poverty alleviation programs, and use of local government funds to cover some costs to reduce out-of-pocket expenses. However, there are several challenges in reducing the financial burdens faced by TB patients. First, medical costs must be contained by reducing the profit-maximizing behaviors of hospitals. Second, treatment for TB and multi-drug resistant TB (MDR-TB) is only available at county hospitals and city or provincial hospitals, respectively, and these hospitals have low reimbursement rates and high co-payments. Third, many patients with TB and MDR-TB are at the edge of poverty, and therefore ineligible for medical assistance, which targets extremely poor individuals. In addition, the local governments of less developed provinces often face fiscal difficulties, making it challenging to use of local government funds to provide financial support for TB patients. We suggest that stakeholders at multiple sectors should engage in transparent and responsive communications, coordinate policy developments, and integrate resources to improve the integration of social protection schemes.Conclusions:The Chinese government is examining the establishment of multi-source financing for TB treatment by mobilization of funds from the government and social protection schemes. These efforts require strengthening the cooperation of multiple sectors and improving the accountability of different government agencies. All key stakeholders must take concrete actions in the near future to assure significant progress toward the goal of alleviating the financial burden faced by TB and MDR-TB patients.

简介：Aimingattheproblemssuchasmorerepeatedlydesignandlongerdesigncycle,inthispaper,thesimilaritytheorywasintroducedtothedesignprocessofthekeystructuresofflotationmachine.TheimpellerandU-shapedtankofflotationmachinesystemwereanalyzedassimilarityunit.Meanwhile,thelevelofsimilarityoftheunitsandthesimilarityofthesystemwerecalculated.BasedontheanalysisoftheimpellerandthesizeofU-shapedtank,thesimilaritycriteriawerederived.Thederivedconclusionsare:(1)Therelationshipbetweenthediameteroftheimpellerandthevolumeofthetankwaspowerfunctionandcalculatedasthesimilaritycriteriaoftheimpeller;(2)TherelationshipbetweentheratiobetweentheU-shapedtank’scross-sectionalareaandimpeller’sdiameterandthevolumeofthetankwaspowerfunctionandcalculatedasthesimilaritycriterionsoftheU-shapedtank.Usingthesimilaritycriterioncombinedwithcomputertechnologyanddatabasetechnologytorealizepartandsystemserializationdesign.Theresultsshowthattheresearchcanavoidrepeatedlydesign,shortendesigncycle,andraisethedesignefficiency.

简介：在热带气旋(TC)的最近的趋势和可变性频率和紧张为影响了中国的TC被检验，与影响的那些TC的特别焦点，瓷器给经济地区调音(例如，长江三角洲，珀尔河三角洲，和北京天津区域)。结果证明微弱地影响中国的TC的频率在1980年代和2000年代期间衰退了，由细微增加列在后面。TC频率的时间系列在过去的60年期间在26年的时期显示出不足道的变化；这些变化显著地与ENSO活动被相关。当影响长江三角洲的TC的频率不是时，影响珍珠河三角洲区域的TC的频率强烈与ENSO周期被相关。TC频率为不同紧张的TC不同地变化。影响中国的热带暴风雨(TS)在全部的数字是小的，但是清楚地在频率增加了。严重热带暴风雨(圣)的频率，台风(TY)，严重台风(猪圈)，和影响中国的超级台风(超级TY)在1970年代期间显著地衰退了，猪圈和超级TY的1980年代，而是数字在2000年代上增加了。影响中国的TC的典型紧张在60年的timeframe上衰退了，但是在最近的10年(20002010)增加了。TC的紧张的这增加特别地影响了长江三角洲区域，它经历了猪圈和超级TY的增加的数字。这些趋势特别地在完整的60年的分析时期和最近的10年的时期期间在一般来说影响两个中国的TC和长江三角洲的最大的紧张的变化被观察；然而，这些趋势没在TC的平均紧张的变化被观察。由对比，极端紧张和影响珍珠河三角洲的TC的平均紧张在整个分析时期减少了，包括最近的十年。

简介：Historically,mastcellswereknownasakeycelltypeinvolvedintypeIhypersensitivity.Untillasttwodecades,thiscelltypewasrecognizedtobewidelyinvolvedinanumberofnon-allergicdiseasesincludinginflammatoryboweldisease(IBD).MarkedlyincreasednumbersofmastcellswereobservedinthemucosaoftheileumandcolonofpatientswithIBD,whichwasaccompaniedbygreatchangesofthecontentinmastcellssuchasdramaticallyincreasedexpressionofTNFα,IL-16andsubstanceP.TheevidenceofmastcelldegranulationwasfoundinthewallofintestinefrompatientswithIBDwithimmunohistochemistrytechnique.ThehighlyelevatedhistamineandtryptaselevelsweredetectedinmucosaofpatientswithIBD,stronglysuggestingthatmastcelldegranulationisinvolvedinthepathogenesisofIBD.However,littleisknownoftheactionsofhistamine,tryptase,chymaseandcarboxypeptidaseinIBD.Overthelastdecade,heparinhasbeenusedtotreatIBDinclinicalpractice.Thelowmolecularweightheparin(LMWH)waseffectiveasadjuvanttherapy,andthepatientsshowedgoodclinicalandlaboratoryresponsewithnoseriousadverseeffects.TherolesofPGD2,LTC4,PAFandmastcellcytokinesinIBDwerealsodiscussed.Recently,aseriesofexperimentswithdispersedcolonmastcellssuggestedthereshouldbeatleasttwopathwaysinmanformastcellstoamplifytheirownactivation-degranulationsignalsinanautocrineorparacrinemanner.Thehypothesisisthatmastcellsecretogoguesinducemastcelldegranulation,releasehistamine,thenstimulatetheadjacentmastcellsorpositivelyfeedbacktofurtherstimulateitshostmastcellsthroughH1receptor.Whereasreleasedtryptaseactssimilarlytohistamine,butactivatesmastcellsthroughitsreceptorPAR-2.Theconnectionsbetweencurrentanti-IBDtherapiesorpotentialtherapiesforIBDwithmastcellswerediscussed,implicatingfurtherthatmastcellisakeycelltypethatisinvolvedinthepathogenesisofIBD.Inconclusion,whilepathoge