简介：目前，铬过敏已与Cr（Ⅵ）过敏同义。然而，真正接触到的皮革制品中的铬可能包括Cr（Ⅲ）及Cr（Ⅵ）。本研究中，作者调查了一系列患者对Cr（Ⅲ）及Cr（Ⅵ）的反应性，以分析足部湿疹／接触皮革与Cr（Ⅲ）反应性的关系。2002年3月至2004年12月间，作者对连续收治的2211例疑有变态反应性接触性皮炎的患者进行斑贴试验，斑贴制剂为0．5％重铬酸钾[Cr（Ⅵ）]及13％三氯化铬[Cr（Ⅲ）]。共有71例患者（3．2％）对Cr（Ⅵ）发生阳性反应，其中31例同时对Cr（Ⅲ）发生阳性反应。没有Cr（Ⅵ）阴性患者对Cr（Ⅲ）发生阳性反应。作者发现Cr（Ⅵ）阳性同时伴发Cr（Ⅲ）阳性或可疑阳性的患者发生足部皮炎的危险性较仅Cr（Ⅵ）阳性而Cr（Ⅲ）阴性的患者高。危险性增加不是因为对Cr（Ⅵ）的敏感度较高。据报道皮革最常作为铬皮炎的可疑病因（54％）。然而，患有足部湿疹及对Cr（Ⅲ）发生阳性或可疑反应的Cr（Ⅵ）过敏者常对其他鞋部变应原发生阳性反应。因而，Cr（Ⅲ）过敏是对多种鞋部变应原过敏的一部分。

简介：Objective:AllelicpolymorphismsofCCR5△32、CCR2b-64I,CX3CR1-249I280MandSDF1-3’AassociatedwithHIV-1infectionanddiseaseprogressionwereinvestigatedinindigenousUygurpopulationsfromtheXinjiangUygurAutonomousRegionofChina.Mithods:Thestudypopulationcomprised316healthyUygursubjectswithanagerangeof1-80yearsold,fromwhomwholeperipheralbloodsampleswerecollectedandnonewereHIV-1seropositive.GenomicDNAsampleswerepurifiedusingaQiagenBloodKit.GenotypingoftheaforementionedfouralleleswasperformedusingPCRorPCR/RFLPassay,andfurtherconfirmedbydirectDNAsequencing.Results:TheallelicfrequenciesinChineseUygurpopulationwereasfollows:3.48%forCCR5△32;19.45%forCCR2b-64I;13.8%forCX3CRI-249I280Mhaplotype,and20.41%forSDFI-3’A.MutantalleledistributionsamongUygurpopulationswereinaccordancewiththeHardy-Weinbergequilibrium.NostatisticaldifferencewasfoundbetweenthefrequencyofthethreeHIVcoreceptorsandtheirrespectiveligandgenes.Conclusion:ThefrequencyofSDF1-3’AandCX3CR1-249I280MhaplotypemorecloselymatchedthehanChinese.ThefequencyofCCR5△32inUygurpopulationswasbetweenCaucasianandHanfrequencies,themorecloselymatchingthefrequencyinMedi-Asiapeople.NogeneticlinkagebetweenanytwoofthethreeHIVcoreceptorgeneswasfound,butobviousgeneticlinkagesexistedbetweenCX3CR1-249IandCX3CR1-280M,withevenhigherlinkagedegreesthanCaucasianpeople.