简介：Thepaperpresentsamulti-scalemodellingapproachforsimulatingmacromoleculesinfluidflows.Macromoleculetransportatlownumberdensitiesisfrequentlyencounteredinbiomedicaldevices,suchasseparators,detectionandanalysissystems.Accuratemodellingofthisprocessischallengingduetothewiderangeofphysicalscalesinvolved.Thecontinuumapproachisnotvalidforlowsoluteconcentrations,butthelargetimescalesofthefluidflowmakepurelymolecularsimulationsprohibitivelyexpensive.Apromisingmulti-scalemodellingstrategyisprovidedbythemeta-modellingapproachconsideredinthispaper.Meta-modelsarebasedonthecoupledsolutionoffluidflowequationsandequationsofmotionforasimplifiedmechanicalmodelofmacromolecules.Theapproachenablessimulationofindividualmacromoleculesatmacroscopictimescales.Meta-modelsoftenrelyonparticle-correctoralgorithms,whichimposelengthconstraintsonthemechanicalmodel.Lackofrobustnessoftheparticle-correctoralgorithmemployedcanleadtoslowconvergenceandnumericalinstability.AnewFAstLinearCOrrector(FALCO)algorithmisintroducedinthispaper,whichsignificantlyimprovescomputationalefficiencyincomparisonwiththewidelyusedSHAKEalgorithm.ValidationofthenewparticlecorrectoragainstasimpleanalyticsolutionisperformedandimprovedconvergenceisdemonstratedforssDNAmotioninalid-drivenmicro-cavity.

简介：Oneofmanyinterestingresearchactivitiesinbiofluidmechanicsisdedicatedtoinvestigationsoflocomotioninwater.Someofpropulsionmechanismsobservedintheunderwaterworldareusedinthedevelopmentprocessofunderwaterauto-nomicvehicles(AUV).Inordertocharacteriseseveralsolutionsaccordingtotheirmanoeuvrability,influenceonthesur-roundingfluidandenergeticefficiency,adetailedanalysisoffin-likemovementisindispensable.Inthecurrentpaperananalysisofundulatory,oscillatoryandcombinedfin-likemovementsbymeansofnumericalsimulationiscarriedout.TheconservationequationofmassandtheconservationequationofmomentumaresolvedwiththeFiniteVolumeMethod(FVM)byuseofthesoftwareCFX-10.0.Theundulatoryandoscillatoryfinmovementsaremodelledwithanequationthatisimplementedwithinanadditionalsubroutineandjoinedwiththemainsolver.Numericalsimulationsarecarriedoutinthecomputationaldomain,inwhichonefinisfixedinaflow-throughwaterduct.SimulationsarecarriedoutintherangeoftheRenumberupto105.Theresultsshowsignificantinfluenceofappliedfinmotiononthevelocitydistributioninthesurroundingfluid.

简介：Overthelastdecade,computationalmethodshavebeenintensivelyappliedtoavarietyofscientificresearchesandengi-neeringdesigns.Althoughthecomputationalfluiddynamics(CFD)methodhasplayedadominantroleinstudyingandsimu-latingtransportphenomenainvolvingfluidflowandheatandmasstransfers,inrecentyears,othernumericalmethodsforthesimulationsatmeso-andmicro-scaleshavealsobeenactivelyappliedtosolvethephysicsofcomplexflowandfluid-interfaceinteractions.Thispaperpresentsareviewofrecentadvancesinmulti-scalecomputationalsimulationofbiomimeticsrelatedfluidflowproblems.Thestate-of-the-artnumericaltechniques,suchaslatticeBoltzmannmethod(LBM),moleculardynamics(MD),andconventionalCFD,appliedtodifferentproblemssuchasfishflow,electro-osmosiseffectofearthwormmotion,andself-cleaninghydrophobicsurface,andthenumericalapproachesareintroduced.Thenewchallengingofmodellingbiomi-meticsproblemsindevelopingthephysicalconditionsofself-cleanhydrophobicsurfacesisdiscussed.