简介:我的HPNC6000用的是ATl9600(32MB)显卡的啊,但怎么玩起CS来还不如长城的T2000D呢?不是一样都用ATI9600的吗?还是我的机器问题?
简介:Theinflammatoryprocessplaysacentralroleinthedevelopmentandprogressionofnumerouspathologicalsituations,suchasinflammatoryboweldisease(IBD),autoimmuneandneurodegenerativediseases,metabolicsyndrome,andcardiovasculardisorders.IBDsinvolveinflammationofthegastrointestinalareaandmainlycompriseCrohn’sdisease(CD)andulcerativecolitis(UC).Bothpathologicalsituationsusuallyinvolverecurringorbloodydiarrhea,pain,fatigueandweightloss.ThereisatpresentnopharmacologicalcureforCDorUC.However,surgerymaybecurativeforUCpatients.Theprescribedtreatmentaimstoamelioratethesymptomsandpreventand/ordelaynewpainfulepisodes.Flavonoidcompoundsarealargefamilyofhydroxylatedpolyphenolicmoleculesabundantinplants,includingvegetablesandfruitswhicharethemajordietarysourcesofthesecompoundsforhumans,togetherwithwineandtea.Flavonoidsarebecomingverypopularbecausetheyhavemanyhealth-promotinganddisease-preventiveeffects.Mostinteresthasbeendirectedtowardstheantioxidantactivityofflavonoids,evidencingaremarkablefree-radicalscavengingcapacity.However,accumulatingevidencesuggeststhatflavonoidshavemanyotherbiologicalproperties,includinganti-inflammatory,antiviral,anticancer,andneuroprotectiveactivitiesthroughdifferentmechanismsofaction.ThepresentreviewanalyzestheavailabledataaboutthedifferenttypesofflavonoidsandtheirpotentialeffectivenessasadjuvanttherapyofIBDs.
简介:Inflammatorydemyelinatingpseudotumorusuallyoccursinthebrainandrarelyoccursinthespinalcord.Onimaging,inflammatorydemyelinatingpseudotumorappearsverysimilartointramedullarytumorssuchasgliomas.Itisoftenmisdiagnosedasintramedullarytumorandsurgicallyresected.Inviewofthis,theclinicalandmagneticresonanceimagingmanifestationsandthepathologicalfeaturesof36casesofinflammatorydemyelinatingpseudotumorinthespinalcordwereretrospectivelyanalyzedandsummarized.Mostofthesecasessufferedfromacuteorsubacuteonsetandexhibitedasensorimotordisorder.Amongthem,sixcasesweremisdiagnosedashavingintramedullarygliomas,andinflammatorydemyelinatingpseudotumorwasonlyidentifiedandpathologicallyconfirmedaftersurgicalresection.Lesionsinthecervicalandthoracicspinalcordwerecommon.Magneticresonanceimagingrevealededemaandspace-occupyinglesionstovaryingdegreesatthecervical-thoracicjunction,withapredominantfeatureofnon-closedrosette-likereinforcement(open-loopsign).Pathologicalexaminationshowedperivascularcuffingofpredominantlydenselymphocytes,anddemyelinationwasobservedinsixofthemisdiagnosedcases.Theseresultssuggestthattumor-likeinflammatorydemyelinatingdiseaseinthespinalcordisakindofspecialdemyelinatingdiseasethatcanbecategorizedasinflammatorypseudotumor.Thesesolitarylesionsareeasilyconfusedwithintramedullaryneoplasms.Patchyornon-closedreinforcement(open-ringsign)onmagneticresonanceimagingisthepredominantpropertyofinflammatorydemyelinatingpseudotumor,andinflammatorycellinfiltrationanddemyelinationareadditionalpathologicalproperties.
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简介:针灸在煽动性的肠疾病(IBD)的治疗的好治疗学的效果,而是它的功能的机制系统地没被解释。Metabolomics是象生活有机体的新陈代谢的反应一样包含代谢物的动态化学过程的科学学习。Metabolomics,有正直和动力学的一个研究方法,对应于针灸的全面规章的效果并且与繁体中文药(TCM)的全面概念和动态平衡的概念一致。在最近的年里,metabolomics广泛地被用于IBD的临床、试验性的学习,并且它的潜在的应用价值是一致地由研究人员承认了。在这篇文章,在针灸的metabolomics的申请地位被总结,并且由metabolomics在IBD的规定和控制学习针灸的机制的研究想法preliminarily被探索。
简介:AbstractBackground:Asthma is a heterogeneous disease with distinct prevalence and manifestation between sexes. This study was to identify sex-specific features of asthma via metabolomic analysis of sphingolipids.Methods:Forty-two asthma patients (27 women and 15 men) admitted to the Peking University Third Hospital from January 2015 to December 2015 were enrolled. Peripheral venous blood was collected for metabolomic analysis by targeted liquid chromatography-mass spectrometry. Sex hormones(estradiol, progesterone, testosterone, and androstenedione) and multiple inflammatory factors (periostin, leptin, IgE, IL-4, IL-5, IL-10, IL-13, IL-17A, and IFN-γ) were also assessed. The eosinophil percentage in induced sputum was also detected. All these data were applied to comparative analysis between sexes.Results:Testosterone was negatively related to periostin (ρ = -0.420, P = 0.009) and IL-5 (ρ = -0.540, P = 0.012), while estradiol was positively related to the blood eosinophil percentage (ρ = 0.384, P = 0.025). Among the eighteen species of sphingolipids detected in the 42 patients, five ceramide (Cer) species (Cer16:0, Cer:20:0, Cer22:0, Cer24:0, and Cer26:0) and one sphingomyelin (SM) species (SM38:0) were significantly higher in male than in female patients. Further investigation found that the correlation between Cer20:0 and IL-5 was positive in males (ρ = 0.943, P = 0.005) but negative in females (ρ = -0.561, P = 0.030).Conclusions:Testosterone was negatively correlated with eosinophil inflammatory factors, but estradiol was positively correlated. Male asthma patients had higher ceramide and sphingomyelin levels than female patients. Different sexes had opposite correlations with ceramide and IL-5, respectively, suggesting that therapeutic strategies targeting ceramide should be different between sexes.
简介:AbstractThe human gastrointestinal tract accommodates an entire micro-environment for divergent physiologic processes, the dysbiosis of this micro-ecology has a strong inter-action with the pathogenesis of inflammatory bowel disease (IBD). In the past few years, with the advances in the understanding of microbiome, its metabolites and further application of next generation sequencing, analysis of dynamic alteration of gut micro-environment was realized, which provides numerous information beyond simple microbiota structure or metabolites differences under chronic colitis status. The subsequent intervention strategies targeting the modulation of intestinal micro-environment have been explored as a potential therapy. In this review, we will summarize the recent knowledge about multi-dimensional dysbiosis, the inter-action between fungus and bacteria under inflamed mucosa, and the clinical application of probiotics and fecal microbiota transplantation as a promising therapeutic approach in IBD.
简介:客观:与严重煽动性的反应症候群(先生)在创伤的病人调查甲状腺荷尔蒙的引申。方法:有严重先生的五十个创伤的病人被注册并且根据他们是否介绍了multiorgandysfunction症候群(MODS)把组划分了成二。甲状腺荷尔蒙大小被拿,包括totaltriiodothyronine(TT3),全部的甲状腺素(TT4),免费triiodothyronine(FT3),免费甲状腺素(FT4)和甲状腺刺激荷尔蒙(TSH)。尖锐生理学和长期的健康评估Ⅱ(APACHEⅡ)20根据临床的数据被计算。恢复或恶化的结果被记录,以及从到时间甲状腺荷尔蒙的先生的发作的时间的长度被测量。结果:Euthyroid病了的症候群(S字)在45cases.TT3水平被介绍否定地与APACHEH分数被相关(r=-0.330,P<0。05),并且TT3/TT4value否定地与先生的持续时间被相关(r=-0.316,P<0.05)。没有MODS,在MODS病人的TT3,TT4和FT3levels是比那些显著地低的(P<0.05)。没有MODS,给低TT4或FT4的MODS病人比那些经常铺平更多(P<0.05)。与在正常TSH组的病人相比,有有的减少的TSH的病人降低T3,T4,恢复率和更高的APACHEⅡ分数,MODS发生,但是二个组之间没有差别(P>0.05).Conclusions:有严重先生的损伤病人有高可能性得到S字,它更经常并且严重地发生在MODS病人。它在甲状腺轴上显示出先生的影响。Withthe坚持和先生的恶化,有甲状腺荷尔蒙的进步减小。
简介:通过ubiquitin-proteasome系统的蛋白质降级是细胞内部的蛋白质的non-lysosomal解朊作用的主要小径。它在象房间周期的规定那样的许多基本细胞的过程起重要作用有免疫力、煽动性的回答的前进,分割,开发和区别,apoptosis,房间trafficking,和调整。这个系统的中央元素是到指向的蛋白质的ubiquitin的连接,它是然后由26Sproteasome认出了的共有原子价,腺苷triphosphate依赖的、多催化的朊酶。损坏,氧化,否则象控制许多批评细胞的函数的规章的蛋白质一样的错误褶层蛋白质在这降级进程的目标之中。这个系统的错误导致细胞的动态平衡的dysregulation和多重疾病的发展。在这评论,我们在煽动性、自体免疫的疾病的开发描述了基本生物化学和ubiquitin-proteasome系统,和它的复杂角色的分子的生物学。另外,与ubiquitin-proteasome系统有关的治疗和潜在的治疗学的目标也被讨论。细胞与分子的免疫学。2006;3(4):255-261。