简介:摘要目的了解某社区死亡原因、死因顺位及平均死亡年龄等情况,为疾病预防工作提供科学依据。方法根据某社区派出所2016年死亡信息进行统计分析。结果该社区2016年死亡344人,其中男195人,死亡率839.79/10万,女149人,死亡率578.37/10万,男性死亡率高于女性(P<0.05);男性平均死亡年龄76±14.30岁,女性平均死亡年龄81±12.18岁,男性平均死亡年龄显著低于女性(P<0.05);前5位的死因依次为心血管疾病、恶性肿瘤、呼吸系统疾病、脑血管疾病、意外伤害。结论心血管疾病、恶性肿瘤、呼吸系统疾病、脑血管疾病、意外伤害是导致死亡的主要原因,应制定针对性的预防措施,卫生、政府及相关部门应给予高度重视。男性因慢性非传染性疾病影响健康的问题更为突出。
简介:摘要:目的 分析2016-2020年泉州市流感监测结果,研究我市流感病毒流行特征规律,为疾病防控提供依据。方法 针对2016-2020年泉州市10657例流感样病例(ILI)咽拭子标本,采用实时荧光定量RT-PCR技术进行病原检测及分型。结果 2016-2020年共检测10657例ILI,核酸阳性率为14.36%,H1N1、H3N2、Bv、By构成比分别为27.64%、31.57%、26.60%、14.18%;各年度间阳性率及其型别分布差异均有统计学意义
简介:3-去氮-NeplanocinA(3-DNPA,2)是具有很强抗病毒抗肿瘤活性的碳环核苷。发展其有效的合成路线,有助于其类似物的合成及进一步的生物活性研究。由2,4.二羟基-3-硝基吡啶起始的3-去氮嘌呤合成,采用-釜反应直接构建咪唑环,避免了中间体10被氧化;同时,碱基合成中副产物11.1的发现和结构确证,提示了一条合成1-去氮嘌呤的新方法。采用微波辅助方法提高了6-氯-3-去氮嘌呤12的肼解及随后的Boc保护制备17的反应产率;而后者提高了偶联反应N9异构体的比例。全部合成工作经十步反应得到3-DNPA,总收率11.2%。
简介:摘要目的研究分析2015年-2016年南县麻疹监测结果。方法应用描述性流行病学的方法对南县2015-2016年麻疹患者的临床资料进行研究。结果麻疹监测信息报告管理系统运转正常,系统疫警灵敏;南县2015年-2016年发热出疹性病例共59例,其中2015年38例,2016年21例,两年间每位麻疹监测病例第1份血清标本采集率、第2分血清标本采集率、标本3天内送达率和7天内报告率呈逐年上升趋势,麻疹监测系统运转质量较好;两年本县无麻疹爆发疫情及麻疹死亡病例;分布人群以一岁及以下散居儿童为主,两年间对南县人民医院、南县妇幼保院和南县中医院每旬开展病例主动搜索1次,均未发现漏报病例。结论麻疹监测在了解麻疹发病原因上起到重要作用,提高适龄儿童的麻疹疫苗接种率能有效降低麻疹的发病率,若能同时加强对散居儿童的管理将会有效控制麻疹的传播。
简介:Acutemyeloidleukemia(AML)isaclonaldisordercharacterizedbytheaccumulationofcomplexgenomicalterationsthatdefinethediseasepathophysiologyandoveralloutcome.RecentadvancesinsequencingtechnologieshavedescribedthemolecularlandscapeofAMLandidentifiedseveralsomaticalterationsthatimpactoverallsurvival.Despitealltheseadvancement,severalchallengesremainintranslatingthisinformationintoeffectivetherapy.HereinwewillreviewthemolecularlandscapeofAMLanddiscusstheimpactofthemostcommonsomaticmutationsondiseasebiologyandoutcome.
简介:AbstractBackground:Malaria surveillance system strengthening is essential in the progress towards malaria elimination. In Nigeria, more attention is being given to this recently as the country is striving towards achieving elimination. However, the surveillance system performance is fraught with challenges including poor data quality with varying magnitude by state. This study evaluated the operation of the Kano State malaria surveillance system and assessed its key attributes.Methods:An observational study design comprising a survey, record review and secondary data analysis, and mixed methods data collection approach were used. Four key stakeholders' and 35 Roll Back Malaria Focal Persons (RBMs) semi-structured interviews on operation of the system and attributes of the surveillance system, were conducted. We analyzed the abstracted 2013-2016 National Health Management Information System web-based malaria datasets. The surveillance system was evaluated using the "2001 United States Centers for Disease Control's updated guidelines for Evaluating Public Health Surveillance Systems". Data were described using means, standard deviation, frequencies and proportions. Chi-squared for linear trends was used.Results:Overall, 24 RBMs (68.6%) had ≤ 15-year experience on malaria surveillance, 29 (82.9%) had formal training on malaria surveillance; 32 RBMs (91.4%) reported case definitions were easy-to-use, reporting forms were easy-to-fill and data flow channels were clearly defined. Twenty-seven respondents (69.2%) reported data tools could accommodate changes and all RBMs understood malaria case definitions. All respondents (4 stakeholders and 34 RBMs [97.1%]) expressed willingness to continue using the system and 33 (84.6%) reported analyzed data were used for decision-making. Public health facilities constituted the main data source. Overall, 65.0% of funding were from partner agencies. Trend of malaria cases showed significant decline (χ2trend = 7.49; P = 0.0006). Timeliness of reporting was below the target (≥ 80%), except being 82% in 2012.Conclusions:Malaria surveillance system in Kano State was simple, flexible, acceptable, useful and donor-driven but the data were not representative of all health facilities. Timeliness of reporting was suboptimal. We recommended reporting from private health facilities, strengthening human resource capacity for supportive supervision and ensuring adequate government funding to enhance the system's representativeness and improve data quality.
简介:Theincidenceofpapillarythyroidcarcinoma(PTC)hasexponentiallyincreasedinrecentyears.Papillarythyroidmicrocarcinoma(PTMC)accountsforthemajorityofthereportedcasesofPTC.ThedebatesandcrucialissuesinPTMCmanagementhavereceivedresearchers'attention.TofurtherimprovetheclinicalmanagementofPTMCinChina,