简介：Thelackofefficientandnon-toxicgenedelivery,preferablywithnon-viralDNAvectors,isgenerallyregardedasamajorlimitationforgenetherapy.Inthisstudy,awheathistoneH4genewasclonedfromTriticumaestivum,sequenced,modifiedandexpressedinE.coli.ThewheathistoneH4geneandreconstructedH4TLgeneencodedwheathistoneH4andarecombinantproteinof141aminoacidswithanapproximatemolecularweightof15500.GelelectrophoresismobilityshiftassaysdemonstratedthatthepurifiedproteinhadhighaffinityforDNA.Mostsignificantly,thecomplexofplasmidpEGFP/C1withH4TLwastransfectedwithincreasedefficiencyintoMCF-7,HO8910,LNCap,A549andHeLacellsinvitro.Theseresultsdemonstratethatthetargetingofnon-viralvectorstotumor-specificreceptorsprovidesacheap,simpleandhighlyefficienttoolforgenedelivery.

简介：在这研究，新有点磁性、光的Fe3O4/CdTenanocomposites的准备被表明。SuperparamagneticFe3O4nanoparticles被铁、铁的离子的热水的一起沉淀首先综合，与丁氨二酸酸与tetramethylammonium氢氧化物(TMAOH)和化学激活由他们的表面的修正列在后面。修改表面的Fe3O4nanoparticles当时与CdTe量点(QD)是covalently涂的，它与mercaptoacetic酸(MPA)被修改，到通过Fe3O4和carboxyl的表面上的氨基的组的协作的Fe3O4/CdTe磁性、光的nanocomposites在CdTeQD上组织的形式。同样综合的nanocomposites的结构和性质被描绘。nanocomposites与40-50nm，黄绿色的排放特征和房间温度强磁性的一条平均直径拥有了结构，这被显示。荧光和nanocomposites的紫外力的吸收系列显示出CdTeQD与那些作比较的蓝移动。蓝移动的机制被介绍。nanocomposites与8.9emu/g的浸透磁化保留了铁磁性的性质。

简介：ThecrystalstructureofN-(2,3,4,6-tetra-O-acetyl-β-D-gly-cosyl)-thiocarbamicbenzoylhydrazine(C22H27N3O9S)wasdeterminedbyX-raydiffractonmethod.Thehexopyranosylringadoptsachairconformation.Alltheringsubstituentsareintheequatorialpositions.Theacetoxyl-methylgroupisinsynclinalconformation.TheSatomisinsynperiplanarconformationwhilethebenzoylhydrazinemoietyisanti-periplanar.Thethiocarbamicmoietyisalmostcompanarwiththebenzoylhydrazinegroup.Therearetwointramolecularhydrogenbondsandoneintermolecularhydrogenbondforeachmoleculeinthecrystalstructure.Themoleculesformanetworkstructurethroughintermolecularhydrogenbonds.

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简介：微波等离子体光源是一类重要的有较强激发能力的原子发射光谱光源，主要包括微波感生等离子体光源，电容耦合微波等离子体光源及微波等离子体炬光源。本文是微波等离子体光谱技术发展的第二部分，主要介绍了电容耦合微波等离子体光源及微波等离子体炬光源的结构原理和性能。并对它们的技术特点和进展进行评述。

简介：微波等离子体光源是一类有较强激发能力的原子发射光谱光源，主要包括微波感生等离子体光源（MIP），微波电容耦合等离子体光源及微波等离子体炬光源。文章分两部分，第一部分介绍了微波感生等离子体光源的结构原理和性能，并对它们的技术特点和进展进行评述。低功率微波感生等离子体光源用于直接测定溶液中某些痕量金属元素是比较困难的，如Pb，Hg，Se等元素，但它已成功地与气相色谱联用用于测定C，H，O，N，S等难激发的非金属元素。高功率磁场激发的氮一微波感生等离子体光源（N2-MIP），允许使用通用玻璃同心雾化器产生湿试液气溶胶直接进入等离子体核心，等离子体能稳定运行，其分析性能近似于商用ICP光源，且运行费用低廉，是有发展前景的一种新型原子发射光谱光源。

简介：4,5-Diphenyl,4,5-di(4-methylphenyl),4,5-di(4-methoxyphenyl)-2-(2,5-dimethylthioph-en-3-yl)imidazolesweresynthesized.Oxidationoftheobtainedimidazoleswithpotassiumferricyanideinwater-alcoholsolutionofalkaligavethecorrespondingdimers.ThestructureswerecharacterizedbyIR,1HNMR,massspectroscopyandelementalanalysis.Thedimersshowedphotochromisminsolutiononirradiation.

简介：Asimpleandefficientmethodhasbeendeveloped;benzil/benzoinundergoessmoothcondensationwithvarioussubstitutedaldehydeandammoniumacetateinthepresenceofpotassiumdihydrogenphosphate(KH_2PO_4)undermildreactionconditionstoaffordthecorrespondingtrisubstitutedimidazoleinexcellentyields.Themethodforsynthesisofproduct,thereactionmixturewasrefluxinethanolfor40-90min.Thepresentmethodissimple,efficient,andcost-effective.

简介：Twonovelcyclotriphosphazenederivativescontaining6-(4-hydroxyphenyl)-2,2'-bipyridine(hopbp)sidegroups,N_3P_3(dobp)_2(hopbp)_2(1)andN_3P_3(dobp)(hopbp)_4(2)(dobp=2,2'-dioxybiphenyl),weresynthesizedandcharacterized.Thesecompoundsdisplaystrongfluorescentemissionbothinsolutionandinsolidstate.Theirabsorptionandemissionspectraaresensitivetoproton:theadditionofHBF4tothemethanolanddichloromethanesolution(9∶1,volumeratio)ofcompound1ledtoared-shiftfrom350to460nmfortheemissionspectrum,andtheprocesswasalsocharacterizedbyisosbesticpointsofabsorptionspectraat267,287and313nm.

简介：Aseriesofethyl6-alkoxy-7-phenyl-4-hydroxy-3-quinolinecarboxylatesweredesignedandsynthesized.Theirstructureswereconfirmedby~1HNMR,~(13)CNMR,IRandHRMS.ThebiologicalactivitieswereprimarilyevaluatedagainstEimeriatenellaaccordingtoAnticoccidialIndex(ACI)methodinvivo.Theresultsshowedthatcompounds5e,5fand5iexhibitedanticoccidialactivitiesagainstE.tenellaat27mgkg~(-1).

简介：ThecrystalgrowthprocessofZn(Leu)SO4·0.5H2OformwaterandacetonewasinvestigatedusingaCalvetmicrocalorimeter.Theheatandtherateofheatproductionduringthecrystalgrowthprocessat293.15K,295.15K,298.15Kand300.15Kweremensured.Onthebasisofexperimentalandcalculatedresults,therateconstantandthekineticparameters(theactivationenergies,thepre-exponential)duringthecrystalgrowthprocesswereobtained.Theresultsshowthatthecrystalgrowthprocesswereobtainged.TheresultsshowthatthecrystalgrowthprocessaccordedwiththeBurton-Cabrera-Franddislocationtheory.

简介：Thetitlecomplex,[La(baec)1/2(H2btec)1/2(H2O)]n(H4btec=1,2,4,5-benzenetetracarboxylicacid)(1)wassynthesizedbythehydrothermalreactionof1,2,4,5-benzenetetracarboxylicdianhydridewithLa(NO3)3·6H2OinH2O,andcrystallizesinthetriclinicsystem,spacegroupP-1withα=0.64403(3)nm,b=0.94500(4)nm,c=0.96380(5)nm,α=88.535(2)°,β=100.314(2)°,γ=76.6470(10)°,V=1.69968(10)nm^3,Z=2,andfinalR=0.0274,Rw=0.0735.In1,eachLa(Ⅲ）ioniscoordinatedbyeightoxygenatomsfromsixcarboxylategroupsandonecoordinatedwatermolecule.TwodifferentcoordinstionmodesofH4btecwerePresentinthestructure,oneofwhichcontainstwoprotonatedcarboxylategrougpstobalancethecharge.

简介：利用直接法合成未见文献报道的K8[ZnMg（H2O）W11O39]·15H2O，通过ICP，IR和XRD等方法对其结构进行表征，结果表明所合成的配合物具有Keggin结构．采用化学热扩渗法对合成配合物进行稀土扩渗实验，经XPS测试表明，有微量的钆渗进配合物的体相，并与组成元素存在键合作用，导电性测试结果表明，扩渗后试样的导电率提高10^5倍，是一种优良的固体电解质，有望成为具有实用价值的功能材料．

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简介：利用杂化密度泛函方法B3LYP结合6-311＋＋g（2df,2p）基组研究了（H2O）m（HBr）n（m＋n≤4）混合团簇的结构及红外光谱.确定了团簇的稳定结构以及键能,发现分子间以红移氢键的形式结合形成混合团簇,且H2O分子个数为3时HBr发生解离.理论模拟了稳定结构的红外光谱,并分析了红外光谱主要吸收峰所对应的振动模式.通过自然键轨道（NBO）分析发现了红移氢键是由质子供体与质子受体间的超共轭作用决定的.

简介：首次采用体外抑制实验检测芦丁、异槲皮苷、紫云英苷、槲皮素4种黄酮化合物对5-脂氧合酶（5-LOX）抑制作用,4种化合物IC50值分别为44.18,94.17,172.49和468.45μmol/L.在超滤液质联用实验中测定4种化合物与5-LOX酶的结合率,其结果与体外抑制实验结果一致,表明芦丁对5-LOX有较强的抑制作用,其次为紫云英苷,而槲皮素和异槲皮苷对5-LOX几乎无作用.

简介：小说荧光灯coumarin-4H-pyran结合被各种各样的合成-ketoesters的三部件的反应在水的媒介与醛和malononitrile完成。除温和反应条件以外，运作的简洁，乏味的分离过程的缺席，因为催化剂是这个方法的突出的优点，便宜、无毒的商业地可得到的cationic表面活化剂cetyltrimethylammonium氯化物(CTAC)使用。

简介：Ahighlyeffcientandgeneralmethodforthesynthesisofpolyfunctionalized4H-pyransisestablishedthroughaone-potmulticomponentcyclocondensationofaromaticaldehydeswithCHacids,malononitrileandethylacetoacetateusingnanosilicasupportedtin(II)chlorideasacatalyst.InthismethodSnCl2/nanoSiO2wasusedasgreenandreusablecatalyst.Excellentyields,shortreactiontimes,simpleworkup,andinexpensivenessandcommerciallyavailabilityofthecatalystaretheadvantagesofthismethod.

简介：Rare-earthcompoundsolidsuperacidSO42-/TiO2/La3+wasprepared.Itscatalyticactivitywasexaminedunderdifferentsyntheticconditionsfortheesterificationofpropanoicacidandn-butylalcoholasprobingreaction.Theoptimumconditionswerealsofound,whichwerethepH=8,thedepositingtimewas24h,themassfractionofLa(NO3)3usedinsolidsuperacidwas5%,theconcentrationofH2SO4was1.25mol/L,thesoakingtimeinH2SO4was16handthecalciningtemperaturewas500°C.TheethyloleatewassynthesizedfromoleicacidandethanolinthepresenceofSO42-/TiO2/La3+.Theoptimumreactionconditionswereobtainedwhichwerethereactiontimewas6h,molarratioofoleicacidtoethanolwas1:4andthemassfractionofcatalystwas4%.

简介：Thetitlecomplexi-C4H9Co（salen）（Py）（Py=pyridine.salen=dianionofdisalicylideneethylenediamine）hasbeenfirstsynthesized.ItscrystalstructurehasbeendeterminedbyX-raydiffractionmethod.ThecrystsisaremonoclinicwithspacegroupP21/C.Theunitcellparametesarepresented.ThestructurehasbeenrefinedtoafinalRof0.038.