简介：SmallRNA(sRNA)-mediatedpost-transcriptionalregulationdiffersfromprotein-mediatedregulation.Throughbasepairing,sRNAcanregulatethetargetmRNAinacatalyticorstoichiometricmanner.Sometheoreticalmodelswerebuiltforcomparisonoftheprotein-mediatedandsRNA-mediatedmodesinthesteady-statebehaviorsandnoiseproperties.ManyexperimentsdemonstratedthatasinglesRNAcanregulateseveralmRNAs,whichcausescrosstalkbetweenthetargets.Here,wefocusonsomemodelsinwhichtwotargetmRNAsaresilencedbythesamesRNAtodiscusstheircrosstalkfeatures.Additionally,thesequence-functionrelationshipofsRNAanditsroleinthekineticprocessofbase-pairinghavebeenhighlightedinmodelbuilding.

简介：SmallRNAhasrecentlydrawnmoreandmoreattention.Inthispaper,weconcentrateontheinfluenceofnoisesongenenetworkregulatedbysmallRNAusingchemicalLangevinequation.Itshowsthatthenoisecancauseoscillationwhentheoscillatedoesnotoccurinthecorrespondingdeterministicsystem.Thecoherenceofthenoiseinducedoscillationreachesamaximumforanoptimalintensityofnoise,andthecoherenceresonanceappearsaccordingly.Thefindingsimplyprobablyomnipresentimportanceofnoiseinthefunctioningprocessoflivingorganism.

简介：Recently,RNAprocessinghasemergedasanovelpathwaythatmaycontributetothemaintenanceofgenomestability[1].Alternativesplicingisakeymolecularmechanismforincreasingthefunctionaldiversityoftheeukaryoticproteomes,butitalsooftenalteredincancer.Mountingevidenceindicatesthatalternativesplicing,theprocessthatallowsproductionofmultiplemRNAvariantsfromeachgene,contributestotheheterogeneityofthedisease[2].Althoughthemechanismofalternativesplicingvariantincancerisunclear,thecancer-specificalternativesplicingvariantshavebeenobservedinavarietyofhumancancersandcancercelllinesandhavebeenconnectedtotumorgenesis.

简介：探讨了氨基酸结构与ＲＮＡ中碱基三字密码间的关系，找到了与决定氨基酸相应碱基三字码的主要因素，指出决定氨基酸三字码的第１，２个码的碱基的亲水性要与氨基酸的亲水性相匹配，强亲水性的碱基与强亲水性的氨基酸相应；第２个码的碱基的亲水性是决定其亲水性的主要因素，而第１个码的碱基亲水必屯有相当的影响，每种氨基酸的碱基三字码个数的多少，以及三字码中第３个码为何种碱基，都与氨基酸的化学结构密切相关，特别是与Ｒ（Ｒ

简介：Thefluorescencequenchingofnaphthalene(2)and1,3-di(α-naphthyl)propane(1)byRNAandbasesinmethanol-water(v:v=1:1)binarysolventsinthepresenceorabsenceofcyclodex-trin(CD)hasbeeninvestigated.Theresultsshowthatboththemonomerandexcimerfluorescenceof1canbequenchedbythesequenchers.Thequenchingandratesdependonthequencherandtem-perature.Itisshownthatthereisacriticaltemperature(Tc)foreachquencher.BelowTc,theexcimerfluorescencespectrashowvibrationalstructuresandtheStern-Volmerplotsarestraightlines(forura-cilandcytosine);whileabovetheTc,thevibrationalstructuresdisappearandtheStern-Volmerplotsdeviatefromlinearityandcurveupward.Theformerisastaticprocess;whilethelatterisamixtureofbothstaticanddynamicprocesses.Theadditionofα-CDhasnoeffectonthefinestructure,whereasβ-CDpreventstheappearanceofthisstructureefficiently.Thequenchingratesbothforthemonomerandexcimerof1bybasesexceptcytosineinthepresenceofβ-CDatambienttemperaturearenotchanged;thequenchingoffluorescenceof1byRNAinthepresenceofβ-CD,however,ishindered.Time-resolvedfluorescencestudyshowsthattheexcimerfinestructuresappearfromthezerotime.Theintensityoffinestructuresdependonthefractionofwater(φ)inbinarysolvents,anditisindependentofthepHvalueofthesolvents.ItissuggestedthatbasesandRNAinducedaggregates(perhapsmicrocrystal)areformed,inwhichthemotionofmolecules1islimited.

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