简介:Theoperationprincipleofanarrayedwaveguidegrating(AWG)multiplexerisintroducedandthe4×4AWGwithfollowingdesignparametersisdiscussedindetail,suchasthechoiceofwavelength,theneighboringarrayedwaveguidedistanceΔL,thechannelfrequencyintervalΔf,andthefreespectralrange.Thestructureof4×4AWGisdesignedandtheresultofstimulatedtestisalsogiven.Analysisshowsthatthe4×4AWGischaracterizedbyawidedynamicrange,lowcrosstalk,betterspectrumproperties,andacompactstructure.
简介:Thetitlecompounds4,4'-oxobis(propham)((?)n)(C20H24N2O5,Mr.=372.41)wassynthesizedbytheadditionreactionofcorresponding4,4'-oxobisphenyldiisocyanatewithisopropanol.ThecrystalstructurewasdeterminedbyX-raydiffractionmethod.Thecrystalistriclinicsystem,spacegroupP-1witha=8.5107(17),b=9.1164(18),c=14.5701(3)A,α=80.44(3),β=85.25(3),γ=62.88(3)°,V=992.2(3)A3,Z=2,Dc=1.247g/cm3,F(000)=396,R=0.0520,wR2=0.1434for4336observedreflectionswith[I>2σ(I)].X-rayana...
简介:Themostimportantriskfactorforstrokeandneurodegenerationisaging.Infact,survivalafterstrokediminisheslargelywithaging.Infact,recoveryafterbrainarteryocclusionisdramaticallyworsenedbyaging,evennormalagingisassociatedwithneurondamageandcognitivedecline.Mechanismsinvolvedinaging-related,cognitivedeclineandsusceptibilitytoneurondamageinstrokeandneurodegenerationarelargelyunknown.Oneofthemostimportant
简介:目的:通过蛋白质组技术鉴定针刺抗哮喘血清中差异蛋白,明确针剌抗哮喘效应的物质基础。方法:采用蛋白质双向电泳技术,对针刺抗哮喘血清进行蛋白质组份差异分析,并对差异蛋白质点进行质谱鉴定。结果:双向电泳显示,与其它组相比,肾上腺切除哮喘模型针刺组血清与哮喘模型针刺组血清有一个明显深染的蛋白点(MW=44.1kD,PI=5.1),质谱结果为60S核糖体蛋白L13或假想蛋白FLJ32191;双向电泳显示,与其它组相比,肾上腺切除哮喘模型针刺组血清有两个高峰度蛋白点(MW=39.8kD,PI=4.9和MW=39.5kD,PI=5.0),质谱分析表明依次为锌指蛋白208、甲状腺激素受体相关蛋白;双向电泳显示,肾上腺切除哮喘模型针刺组血清中有两个明显区别于其他组的特有蛋白点(MW=17.3kD,PI〈4.5和16.9kD,PI〈4.5)。质谱分析表明依次为亲环蛋白A、锌指蛋白91。结论:针刺治疗哮喘,是整体调整的多靶点效应,与免疫调节、基因表达、蛋白质合成等密切相关。针刺应答蛋白质功能有待深入研究。
简介:Pleurotussajorcaju(P。sajorcaju),一朵可食、无毒的蘑菇,作为抗氧化剂被评估,antitumor,反煽动性并且antihypertensive活动。P。sajorcaju是糖类,饮食的纤维,必要氨基酸,矿物质,维生素B,folic酸和类固醇的好来源。反煽动性,immunomodulatory和止痛活动水并且P的菌丝体的methanolic摘录。sajorcaju被调查(数据没被显示出)。这发现建议那P提取。sajorcaju能对煽动性、自体免疫的疾病被使用。那么,P。为它的antiarthritic活动检验的sajorcaju。植物与水和甲醇镇定、独立提取。为antiarthritic活动500和1000mg
简介:Cancercellsarewelldocumentedtorewiretheirmetabolismandenergyproductionnetworkstosupportandenablerapidproliferation,continuousgrowth,survivalinharshconditions,invasion,metastasis,andresistancetocancertreatments.SinceDr.OttoWarburg’sdiscoveryaboutalteredcancercellmetabolismin1930,thousandsofstudieshaveshedlightonvariousaspectsofcancermetabolismwithacommongoaltofindnewwaysforeffectivelyeliminatingtumorcellsbytargetingtheirenergymetabolism.Thisreviewhighlightstheimportanceofthemainfeaturesofcancermetabolism,summarizesrecentremarkableadvancesinthisfield,andpointsoutthepotentialstotranslatethesescientificfindingsintolife-savingdiagnosisandtherapiestohelpcancerpatients.
简介:Atpresentwhatarethekeypointsfocusedintheresearchofloop-delayestimationforthedigitalpredistorterintheradiofrequency(RF)poweramplifiersystemisreducingitscomplexityofengineeringrealizationandimprovinganti-jammingabilityandcomputationalspeed.Besides,openingupitsapplicationscopeshouldbecontained.Forthesetargets,anovelmethodincludingintegerloopdelayestimationandfractionalpartisproposed.Theintegerpartappliesamplitude-differencesummationfunctionandthefractionaloneadoptsthemethodoffiniteimpulseresponse(FIR)linearinterpolation.Thealgorithmfindswideapplications.Whatismore,stronganti-jammingabilityandlowcomplexityarealsoitsmerits.Simulationresultssupporttheaboveopinion.Digitalpredistortion(DPD)systembasedonthisalgorithmachievesgoodperformance.
简介:Aseriesofnewflavanonederivativesoffarrerolwasdesignedandsynthesizedasapotentinhibitorofvascularsmoothmusclecells(VSMCs)vegetationaccordingtoaconvenientmethod.Thestructuresofallthesynthesizedcompoundswereconfirmedby1HNMR,13CNMRandEIHR-MS.ThebiologicalactivitiesofthesecompoundsagainstVSMCsinvitrowereevaluated.Theassayresultsindicatethattwocompounds,5,7-dihydroxy-6,8-dimethyl-2-(2-nitrophenyl)chroman-4-one(7f)and2,3-dibromo-4,5-dihydroxydiphenylmethanone(7j)exhibitedhighactivityagainstVSMCsinvitrowithIC50valuesof9.9and6.7μmol/L,respectively,andthepreliminarystructure-activityrelationship(SAR)wasdescribed.
简介:AIMTo在导致的lipopolysaccharide(LPS)上调查asiatic酸(AA)的反煽动性的效果在人的角膜的上皮的房间(HCEC)的煽动性的反应.METHODSCell生存能力用数kit-8(CCK-8)的一个房间被测量试金。量的即时聚合酶链反应(qRT-PCR)被用来决定mRNAinterleukin-8(IL-8)的表示,interleukin-6(IL-6),interleukin-1(IL-1),肿瘤坏死factor-alpha(TNF-),和转变生长因素--(TGF-)在HCEC。细胞内部的反应的氧种类(ROS)用ROS试金工具包被测量。谷胱甘肽(GSH)集中用全部的GSH试金工具包被测量。Akt1和Aktphosphorylation(p-Akt1)层次被西方的弄污测量,immunofluorescence.RESULTSAA在高集中导致了毒性并且显著地在20的集中刺激了HCEC的增长
简介:Theeffectsoftwogeometricrefinementstrategieswidespreadinnaturalstructures,chiralityandself-similarhierarchy,onthein-planeelasticresponseoftwo-dimensionalhoneycombswerestudiedsystematically.Simpleclosed-formexpressionswerederivedfortheelasticmoduliofseveralchiral,antichiral,andhierarchicalhoneycombswithhexagonandsquarebasednetworks.Finiteelementanalysiswasemployedtovalidatetheanalyticalestimatesoftheelasticmoduli.Theresultswerealsocomparedwiththenumericalandexperimentaldataavailableintheliterature.WefoundthatintroducingahierarchicalrefinementincreasestheYoung'smodulusofhexagonbasedhoneycombswhiledecreasestheirshearmodulus.Forsquarebasedhoneycombs,hierarchyincreasestheshearmoduluswhiledecreasingtheirYoung'smodulus.IntroducingchiralitywasshowntoalwaysdecreasetheYoung'smodulusandPoisson'sratioofthestructure.However,chiralityremainstheonlyroutetoauxeticity.Inparticular,wefoundthatanti-tetra-chiralstructureswerecapableofsimultaneouslyexhibitinganisotropy,auxeticity,andremarkablylowshearmodulusasthemagnitudeofthechiralityoftheunitcellincreases.
简介:ToexplorethepolysaccharidesfromselectedseaweedsofAtlanticCanadaandtoevaluatetheirpotentialanti-influenzavirusactivities,polysaccharideswereisolatedfromseveralAtlanticCanadianseaweeds,includingthreeredalgae(Polysiphonialanosa,Furcellarialumbricalis,andPalmariapalmata),twobrownalgae(AscophyllumnodosumandFucusvesiculosus),andonegreenalga(Ulvalactuca)bysequentialextractionwithcoldwater,hotwater,andalkalisolutions.Thesepolysaccharideswereana-lyzedformonosaccharidecompositionandothergeneralchemicalproperties,andtheywereevaluatedforanti-influenzavirusactivities.Totalsugarcontentsinthesepolysaccharidesrangedfrom15.4%(inU.lactuca)to91.4%(inF.lumbricalis);sulfationlevelwasashighas17.6%inapolysaccharidefromU.lactuca,whereasitcouldnotbedetectedinanalikali-extractfromP.palmaria.Forpolysaccharidesfromredseaweeds,themainsugarunitsweresulfatedgalactans(agarorcarrageenan)forP.lanosa,F.lumbricalis,andxylansforP.palmata.Inbrownseaweeds,thepolysaccharideslargelycontainedsulfatedfucans,whereasthepolysaccharidesingreenseaweedweremainlycomposedofheteroglycuronans.ScreeningforantiviralactivityagainstinfluenzaA/PR/8/34(H1N1)virusrevealedthatbrownalgalpolysaccharideswereparticularlyeffective.SeaweedsfromAtlanticCanadaareagoodsourceofmarinepolysaccharideswithpotentialantiviralproperties.