摘要
Deareditors,Neurodegenerativediseasesarenowassociatedwiththeglobalobesityanddiabetesepidemicinthedevelopinganddevelopedworld.Neurodegenerativediseasesareaheterogeneousgroupofdisorderswithcomplexfactorssuchasneurohumoral,endocrineandenvironmentalfactorsinvolvedininductionoftheseneurodegenerativediseases.Thefutureofscienceandmedicineinneurodegenerativediseasesisnowdependentonnutritionalgenomicswithinsulinresistanceamajorfactorintheinductionofneurodegenerativediseases.Nutritionalgenomicsnowinvolvestheanti-aginggeneSirtuin1(Sirt1)thatisimportanttothepreventionofinsulinresistancewithitscriticalinvolvementintheimmunesystem(Martins,2018a,b).Sirt1inactivationleadstotoxicimmunereactionsconnectedtotheaccelerationofneurondeathinvariouscommunities.Appetitecontrolwithrelevancetoimmunometabolismhasbecomeofcriticalimportancetothetreatmentofneurodegeneration(Figure1).NutritionaldietsactivatetheheatshockgeneSirt1topreventtheincreaseinheatshockproteinsconnectedtoautoimmunedisease,mitophagy(Martins,2018a,b)andirreversibleprogrammedcelldeathinglobalpopulations(Figure1).
出版日期
2019年04月14日（中国期刊网平台首次上网日期，不代表论文的发表时间）
