BackgroundInclopidogrel-treatedpatientsundergoingpercutaneouscoronaryintervention(PCI),theeffectofconcomitantuseofPPIsonprognosisremainsunclear.MethodsFromJuly2010toJune2012,600patientsafterimplantationofdrug-elutingstent(DES)wereassignedto3groupsaccordingtothemedicaltherapy:group1(n=200)receivedduralantiplatelettherapy(DAPT)alone(aspirine100mgdailyplusclopidogrel75mgdaily),group2(n=199)receivedDAPTpluspantoprazole20mgdailywhilegroup3(n=201)receivedDAPTplusomeprazole20mgdailyfor1year.Theprimaryoutcomewasmajoradversecardiovascularevents(MACEs)whichcomposeofdeath,nonfatalmyocardialinfarction(MI),nonfatalstroke,targetvesselrevascularization(TVR)orstentthrombosis(ST)at1year.PlateletreactivitywasevaluatedforallpatientsbeforePCIand1yearafterPCI.ResultsTherewasnosignificantdifferenceintheplateletreactivityamongthe3groupsat1-yearfollow-up(27.3%versus29.9%versus29.3%,respectively,P=0.339).Neitherwastheresignificantdifferenceintheincidenceof1-yearMACEs(13%versus14.6%versus12.4%,respectively,P=0.809).ConclusionsConcomitantuseofpantoprazoleoromeprazoledidnotinfluenceplateletreactivityorclinicaleventsinpatientsreceivingDAPTafterimplantationofDES.
