A HYDROGEN BONDING ASSISTED CATALYST SCREENED OUT VIA COMBINATORIAL CHEMISTRY STRATEGY

(整期优先)网络出版时间:2000-01-11
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Possibilitiesforenhancementofcatalyticreactionratebycombiningphasetransfercatalysisandhydrogenbondingofthecatalystwiththesubstrateandreagentwerestudied.Aphasetransfercatalystlibrarywithsixtypolystyrene-supportedquaternaryammoniumsaltcatalystswassynthesized.ThereductionofacetophenonebyNaBH4wasusedastheprobingreactiontoselectouttheostactivecatalystinthelibrarybyusingiterativemethod.whichwasthegel-typetriethanolamineaminsatingstronglyasicanionexchangeresinwiththecrosslinkingdegereeof2%Ahydrogenbondingassistedcatalyticmechanismwasproposedtoexplainthehighcatalyticactivityofthecatalyst.