Hormonesandtheirreceptorsregulatecellgrowth,differentiationandapoptosisandalsoplayimportantrolesinimmunefunction.Recentstudiesonthesubfamilyoftheorphannuclearreceptorsknownasretinoid-acidrelatedorphanreceptors(ROR)haveshedimportantinsightsontherolesofthisgroupofnuclearproteinsinthedevelopmentandfunctionoftheimmunesystem.RORαregulatesinflammatorycytokineproductioninbothinnateandadaptiveimmunesystemwhileRORγregulatesthenormaldevelopmentofTlymphocyterepertoireandsecondarylymphoidorgans.Cellular&MolecularImmunology.2004;1(6):401-407.
