Thispaperproposesanovelideathatclassifiesfaultsintotwodifferentkinds:seriousfaultsandsmallfaults,andtreatsthemwithdifferentstrategiesrespectively.Akindofartificialneuralnetwork(ANN)isproposedfordetectingseriousfaults,andvariablestructure(VS)model-followingcontrolisconstructedforaccommodatingsmallfaults.Theproposedframeworktakesbothadvantagesofqualitativewayandquantitativewayoffaultdetectionandaccommodation.Moreover,theuncertaintycaseisinvestigatedandtheVScontrollerismodified.Simulationresultsofaremotelypilotedaircraftwithcontrolactuatorfailuresillustratetheperformanceofthedevelopedalgorithm.