简介:Staphylococcusepidermidisisoneoftheleadingpathogensofnosocomialinfections.Twenty-eightstrainsofbiofilm-negativeStaphylococcusepidermidis,ofwhichthirteenstrainsconsideredastheclinicalstrainswereisolatedfromcatheters,bloodandurineofpatientsinHuashanHospital(Shang-hai,China)andfifteenstrainsconsideredascommensalstrainswereisolatedfromtheskinofhealthystudentswhohadnocontactwithhospitalsinrecenthalfyear,wereinvestigatedfortheadherencetohumanumbilicalveinendothelialcelllineECV304andhumancervicaladenocareinomacelllineHela,respectively.Ourresultsshowedthattheclinicalstrainsweremuchmoreadhesivetobothcellsthancommensalones.Theendothelialadherencemaybeavirulencefactorassociatedwiththisbacterialpathogenesis.