简介：Angiogenesis在出生后的生命期间在胚胎的脉管的树的发展以及处于几个正常、病理学的条件起一个基本作用。Bloodsupply，由neovascularization建立了，在愈合弯屈期间为histogenesis是必要的以及变长的手足在骨胳的损伤sequalae的治疗广泛地适用。Butlittle注意对这个区域被给予了。这评论试图在机械应力下面总结angiogenesis规定，在愈合的创伤中的angiogenesis的过程和angiogenesis，特别地与紧张压力原则联合。

简介：客观：当在骨头织物工程(TE)和有钛蜂窝胃的公山羊的mandible的部分缺点的修理的脚手架增强了，调查使用自然poritos的可行性。方法：有在大约50%-65%的尺寸和孔的190-230μm的一个毛孔的自然poritos被塑造进小粒的形状5公里x5公里x在尺寸的5尼姑。扩展的自体同源的公山羊的髓间充质的干细胞被recombinant导致人的形态基因的protein-2(rhBMP2)到改进osteoblastic显型。然后，髓导出造骨细胞在4x10~7/ml的密度被播种进poritos并且在培植以前在vitro孵化了48个小时。然后，osteoblasticcells/poritos建筑群被植入进mandible的缺点，缺点被钛蜂窝胃增强。poritos的培植独自扮演了著名计算机生产厂商他控制。骨头新生被估计4，8，在用roentgenographicanalysis和组织学的观察的培植以后的16个星期在16个星期以后被做。结果：新骨头能是observedhistologically在表面上并且在在在cell-seedinggroup的所有标本的自然珊瑚的毛孔，而在控制组没有在构造的中心的成骨过程的证据。结果证明新骨头接枝16个星期成功地在培植以后被恢复。结论：当与髓移植的支架材料由TE方法导出造骨细胞，这研究建议使用多孔的珊瑚的可行性。借助于钛蜂窝胃加强，mandible的缺点能成功地被恢复。它显示出在诊所为骨头缺点的重建使用这个方法的潜力。

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简介：Objective:ToinvestigatethedynamicsofplasmacAMP/Cgmpinpatientsduringcardiacsurgery,anditsrelationshiptotraumaticstress.Methods:Sixteenpatients,aged19.31years±10.4years,whounderwentanopenheartoperationwithcardiopulmonarybypass(CPB)andhypothermiawereservedassubjects.Thearterialplasmaconcentrationsofcyclicadenosinemonophosphate(Camp)andcyclicguanosinemonophosphate(Cgmp)weremeasuredbyradioimmunoassay2hoursbeforeoperation,afterheparinization,20minutesfollowingCPB,attheendoftheoperation,and24and72hourspostoperatively,respectively.Thepatients'preoperativebloodsampleswereheparinizedandthevenousbloodsamplesof30healthyblooddonorsweretakentomeasurethelevelsofCampandcGMPasheparinandnormalcontrolsseparately.Results:Therewerenostatisticaldifferenceamongtheheparincontrol,preoperativelevelandnormalcontrol.ThepeakvaluesofCampandCgmpoccurredduringCPBandplasmaCamplevelschangedsynchronouslywithintensitiesofoperativestimulustohumanbody.HowevercGMPlevelwasmainlyrelatedtotheoperativestimulustotheheartandCPB.TheCampvaluewaspositivelycorrelatedwiththeCgmpvalue(r=0.6313,P＜0.001).Conclusions:Dynamicvariationofplasmacyclicribonucleotidecanbeconsideredasareferenceparameterforintensityoftraumaticstress.

简介：Objective:Toobservetheeffectsofthermalstressonproliferationofhumanvascularendothelialcells(VECs)andexploreitssignificance.Methods:ChangesofVECsproliferationwereinvestigatedwith3H-TdRincorporationmethodafterECV304wastreatedat43℃for2hours,whileexpressionsofintercellularadhesionmolecule-1(ICAM-1),inhibitorofdifferentiation-1(ID1),andP16andP21proteinsweredeterminedbyWesternBlotting.Results:TheeffectofinhibitionofVECsgrowthafterthermalstresswasdetectedby3H-TdRincorporationexperiment.WesternblottingshowedICAM-1,amarkerofactivatedendothelialcells,wasincreasedmarkedlyafterthermalstress.ExpressionofID1proteindeclinedgraduallywithincreasingexpressionsofitsdownstreamgenes,P16andP21followingthethermalstress.Conclusions:ThermalstresscouldstronglyactivateVECsandinhibitproliferationofVECsthroughID1,thusdownregulatingcyclin-dependentkinaseinhibitors,P16andP21,whichmightbeanessentialpathwayforrecoveryofVECsafterthermalstress.

简介：Objective:Toprovideanewmethodtoestimatetheeffectivenessofthoracolumbarvertebralfiniteelementmodel.Methods:amechanicalmodelofhumanthoracolumbarvertebraemotionsegmentwasmadeusingthree-dimensionalfiniteelementmethodandthestressdistributionofverticallycompressedthoracolumbarvertebraewasanalyzed,meanwhile,20patientswithburstfractureofthoracolumbarvertebraeweretestedbyCTtocalculatedaverageCTvalueatascertaineddifferentpointsofthoracolumbarvertebrae.Thecalculatedresultsandeffectivestressatthesamepositionwereanalyzedwithstraightlinecorrelation.Results:ThestresslevelofdifferentpositionofthoracolumbarvertebraeunderverticalcompressiveforcewaspositivelycorrelatedwiththecorrelativeCTvalue,andtheregressivestyle,Y-214.028±45.268x,r=0.7386,P<0.05(N=8)showedastatisticalsignificance.Conclusions:Tostudymechanismofthoracolumbarvertebraeinjuriesunderdifferentforceshasclinicalsignificance.

简介：Objective:Tostudythechangeofthestressshieldingrateofstress-relaxationplateinvivoanditsinfluenceonfracturehealing.Methods:Thediaphysesofbilateraltibiasin70NewZealandrabbitswereosteotomizedandfixedwithstressrelaxationplates(SRP,theSRPgroup)andrigidplates(RP,theRPgroup),respectively.Thefracturehealingprocessinthese2groupswasinvestigatedbyradiography,lightandpolarizedlightmicroscopyandbiomechanicaltestat2to48weekspostoperatively.Results:Earlyafterfixationthestressshieldingratewasabout70%inbothgroups.WhileintheSRPgroupthestressshieldingratedecreasedgraduallyastimepassed,whyichwassignificantlylowerthanthatoftheRPgroup(P<0.05)bytheendofthe8thpostoperativeweek,andstabilizedatthelevelofabout27%at36-48weeksafterfixation.AbundantexternalcallusassociatedwiththeformationofcartilaginouscalluscouldbeobservedintheSRPgroupat2-4weekspostoperatively.Thetransformationofthecallusintothelamellarbonebeganat8-12weeks,thecollagengraduallyarrangedinorder,andthemechanicalnatureoftheunitedbonewasgraduallystrengthened,too.IntheRPgroup,theexternalcalluswasscarceattheearlystageoffracturehealing,andthecallusremodelingatthelatestageoffracturehealingwasdominatedbyboneabsorption.Theultimatebendingstrength(UBS)wasonly57.95%ofthatofthenormalby48weeks.Conclusions:ThedecreaseofthestressshieldingrateofSRPinvivowaswellinterrelatedwiththetimeoffixation.TheapplicationofSRPcouldpromotethecallusformationandbonereconstructionthustofavortherecoveryofthemechanicalstrengthoftheunitedbone.

简介：Objective:Tostudytheinfluenceofstress-relaxationplateondisorganizationandrepairofthecortexbeneaththeplate.Methods:Awashermadeofviscoelasticpolyethylenewasplacedbetweenthescrewandthescrewholeofconventionalstainlessrigidplate(RP)toproduceastressrelaxationplate(SRP).BothSRPandRPwereappliedtoosteotomizedtibiain48NewZealandrabbits.HealingprocessofthefracturewitheitherSRPorRPfixation(control)wascomparativelystudiedwithpolarizedlightmicroscopy,insituhybridizationofcollagenmRNAandimmunohistochemicaltechniquefrom2to36weekspostoperatively.Results:ThestudyofplatedboneremodelingshowedthatthedegreeofcortexosteoporosisbeneaththeplatewassimilarbetweentheSRPandRPgroupwithin12weekspostoperatively.Incomparison,thedisorganizationofbonestructureinSRPgrouphappenedlaterandmilderthanthatofRPgroup,andtherepairprocessbeganat12weeksafterimplantation.Asaconsequence,theabsorptioncavitiesbecamesmallerandthestructureofcollagenfibersbecamewellorientedalongwiththesechangesbypolarizedlightmicroscopy.Inadditiontothese,theinsituhybridizationanalysisofcollagengenesandtheimmunohistochemicalstudyoftypeI,Ⅲcollagenat8to12weeksafterimplantation.fromthistimeon,thechangesabovebecamemoreevidentsignificantlybeforemostofcavitieswererepairedby36weeks.IncontrasttothechangesintheSRPgroup,noexpressionandsynthesisofanykindofcollagencouldbeobservedduring12to36weeksafterimplantationinRPgroup.Conclusions:Withoutremovaloftheboneplate,theSRPfixationnotonlyreducesthedegreeofplatedboneosteoporosis,butalsomakesthedisorganizedbonestructurerestoredtonormalintermsoftheexpressionandsynthesisoftypeIcollagenmRNAofosteoblastslyingonthesurfaceofabsorptioncavities.

简介：目的将创造膝系带并且到压力在不同的膝屈曲侧面的并行的系带(LCL)改变与或没有代替的运动的分析的有限元素模型调节的3-dimensional。four-major-ligament从一个成年人包含了膝标本的方法死于颅骨损害为与精确预先标记的可检测的系带插入脚印，地点和取向扫描的CT作好准备。扫描图象的CT与3-dimensional重建技术被变换成膝的一个3-dimensional模型并且由ANSYS的软件转变了成有限元素模型。模型用另外的科学家获得的试验性、数字的结果被验证。在五个不同的膝屈曲角度的LCL的自然压力变化(0