简介:Personalizedcancermedicinehasseensignificantimprovementsoverthepastdecade.RecentElsevierconference:Miamiwintersymposium2015(MWS2015)'TowardsPersonalizedCancerMedicine'meetingwasdedicatedtothisexcitingfield,andfocusedonnewprogressinpersonalizeddrugdevelopmentandantibodydrugagainstcheckpointpathway.Thismeetingreportsummarizesthekeydevelopmentspresentedanddiscussedatthemeeting,withafocusonimmunotherapy,especiallyontheCTLA-4andPD-1/PD-L1pathways.Themonoclonalantibodydrugsinterveningthesecheckpointpathwayshavethepotentialtoplayalargerroleinpersonalizemedicinewithinthenearfuture.Hereweintendedtoprovideacomprehensivesummaryaboutongoingtrendsandfutureperspectivesonpersonalizedmedicineincancertherapy.
简介:Aparadoxincancerresearchisthatthemajorityofpatientsenrolledinclinicaltrialsarerelativelyyoungandfitwhiletypicalpatientsindailypracticeareelderlyandhavecomorbiditiesandimpairedorganfunction.Giventhesedifferences,manymajorstudiesprovideanimperfectguidetooptimizingthetreatmentofthemajorityofpatients.Sincecancerincidenceishighlycorrelatedwithage,andsincetheworld'spopulationisrapidlyageing,thisproblemcanonlyincrease.Forthisreason,oncologistsandgeriatriciansneedtocollaborateindevelopingtoolstosystematicallyassessthehealthstatusofelderlypatientsandtheirfitnesstoreceivecancertherapiesofvariousintensity.Tailoringanti-cancertreatmentsandsupportivecaretoindividualneedsshouldbeseenaspartofthemovetowardspersonalizedmedicine.Achievingthisgoalisasmuchofachallengetodevelopingandmiddle-incomecountriesasitistowesternnations.The2015annualconferenceoftheInternationalSocietyofGeriatricOncology(SIOG)heldinPrague,CzechRepublic,November2015andhadaglobalfocusonadvancingthescienceofgeriatriconcologyandsupportivecare.Centraltothisapproachisthesystematicassessmentoflifeexpectancy,independentfunctioning,andthephysicalandpsychologicalhealthofoldercancerpatients.Theassumptionbehindcomprehensivegeriatricassessmentisthatelderlycancerpatientshavecomplexneeds.Theimplicationisthateffectiveinterventionwillrequireamultidisciplinaryteam.Examplesofeffectivegeriatricassessment,multidisciplinaryworkingandsupportivecarewerepresentedattheSIOGconference.