简介:Thecentralnervoussystem(CNS)containsthetwomostimportantorgans,thebrainandspinalcord,fortheorchestrationofthementalandphysicalactivitiesoflife.Becauseofitsimportance,thehumanbodyhasevolvedbarriersystemstoprotectCNStissuefromtheexternalenvironment.Thisbarrierisamembranecomposedoftightlyapposedcellsandisselectivelypermeabletospecificmoleculesbywayofmembranetransporters.Themajorbarriersinthebrainandtheircorrespondingcellularconstituentsarethebloodbrainbarrier(BBB)composedofendothelialcellsinbrain