简介:MicroRNAs(米尔)是被报导了正在答应诊断工具的小noncodingRNA。我们使用了量的即时反向的抄写PCR(RT-qPCR)分析在前列腺肿瘤的表示miRNAs取样决定它的预示的价值的差别。从2007~2009,肿瘤纸巾从73个激进的前列腺切除术标本被获得。差别表示了miR-96,-145和-221被TaqManRT-qPCR用所有73纸巾验证。预示的价值用Kaplan-Meier和考克斯回归分析以生物化学的复发被估计。为我们的耐心的队,吝啬的年龄是64.7年(50-76年),吝啬的前列腺特定的抗原(PSA)是7.5 ;ngml−1。在后续时期期间(平均数,19.4个月),73中的14个(19.2%;)病人们发展了生物化学的复发。miR-96,-145和-221的表示与对方一起强烈相关,但是在miRNA表示和clinicopathologic参数之间没有关联。用木头等级测试的Kaplan-Meier幸存曲线与病理学的舞台显示出减少的生物化学的没有复发的间隔(P<;0.001)。另外,有超过8的格利森分数的病人,6与格利森一起与那些相比得分,在Kaplan-Meier分析(P=0.001)显示出减少的生物化学的没有复发的间隔。然而,miR-96,-145和-221的表示没用考克斯在Kaplan-Meier幸存曲线或由multivariate分析与生物化学的复发间隔相关比例的危险回归模型也。在结论,我们没观察在miR-96,-145和-221和clinicopathologic参数的表达式之间的重要关联。为了在临床的实践作为一个诊断工具利用miRNA,更多的研究被需要理解miRNA机制,识别miRNA目标,并且进一步描绘miRNA,工作。
简介:<正>Purpose:Thepurposeofthisstudywastoexamineeffectsofasportversionofasemi-rigidanklebrace(ElementTM)andasoftanklebrace(ASO)onanklebiomechanicsandgroundreactionforces(GRFs)duringadroplandingactivityinsubjectswithchronicankleinstability(CADcomparedtohealthysubjectswithnohistoryofCAI.Methods:Tenhealthysubjectsand10subjectswhohadmultipleanklesprainsparticipatedinthestudyasthecontrolandunstablesubjects,respectively.TheCAIsubjectswereage,bodymassindexandgendermatchedwiththecontrolsubjects.Thearchindexandanklefunctionsofthesubjectsweremeasuredinasubjectscreeningsession.Duringthebiomechanicaltestsession,participantsperformedfivetrialsofdroplandingfrom0.6m,wearingnobrace(NB).Element?braceandASObrace.Simultaneousrecordingofthree-dimensionalkinematic(240Hz)andGRF(1200Hz)datawereperformed.Results:TheCAIsubjectshadloweranklefunctionalsurveyscores.ThearchindexanddeformityresultsshowedgreaterarchdeformityofElementTMagainstastaticloadthaninNBandASOduetogreaterinitialarchpositionheldbythebrace.CAIparticipantshadgreatereversionvelocitythanhealthycontrols.TheASObracereducedthefirstpeakverticalGRFwhereasElementTMincreased2ndpeakverticalGRF.ElementTMbracereducedeversionrangeofmotion(ROM)andpeakeversionvelocitycomparedtoNBandASO.Inaddition,ElementTMreduceddorsiflexionROMandincreasedpeakplantarflexionmomentcomparedtoNBandASO.Conclusion:Resultsofstaticarchmeasurementsanddynamicanklemotionsuggestthattherestrictionsofferedbybothbracesareinpartduetomoredorsiflexedanklepositionsatcontact,andhigherinitialarchpositionandstifferankleforElementTM.
简介:Particlesbehaviourwasmonitoredandanalyzedinastormwaterwetlandoveraperiodof4months(June-September,2009).Theresultsindicatedthattheparticlesbehaviourcanbeaffectedbymanyprocesses,suchassedimentation,resuspension,adsorptionandreleaseinstormwaterwetlandsduringdrydays.Duetotheeffectsofthesefactors,theparticlesremovalefficiencycalculatedbasedonthesettlingtheorywassignificantlyhigherthanthevalueobtainedusingthemeasuredparticlesnumberconcentration.Andthemeasuredefficiencyshowedaturningpointintherangeof2-4μm,whichwaswithinthecolloidalparticlesrange.Analysisofparticlesizedistributionshowedthatparticleswerefinerintheoutflowthaninflowduetosedimentationofthecoarseparticlesandresuspensionofthefineparticlesinthewetland.Particlesindifferentsizerangesplaydifferentrolesintheircontributiontoturbidityandtotalsuspendedsolidsconcentration.Thefinerparticles(lessthan10μm)showedacloserrelationshipwiththeturbiditywhilecoarserparticles(>4μm)weremorerelatedtototalsuspendedsolidconcentration.