简介:目的:建立BioOcular^TM角膜上皮模型EIT法评价眼用制剂包装材料眼刺激性的方法。方法:采用BioOcular^TM角膜上皮模型EIT法,通过对不同暴露时间,不同浸提条件,不同浸提浓度和不同浸提介质的比较分析,确定使用该方法进行眼用制剂包装材料眼刺激性的检测方法。结果:取样品内表面积120cm^2,剪碎,加入氯化钠注射液20mL,密封后,置高压蒸汽灭菌器内,在110℃保持30min。按BioOcular^TM角膜上皮模型EIT法进行检测,组织活性平均值应不低于80%。结论:该方法可以用于检测眼用制剂包装材料的眼刺激性。
简介:Objective:Establishnormativedatafortympanicelectrocochleography(TMECochG)parametersinnormalhearingadultswithoutMeniere'sdisease's(MD)symptoms.DescribeTMECochGvariablesthathelptodistinguishnormalfromMDears.Materialandmethods:Weenrolled100subjects(N?200ears),59females,agedbetween19and71yearsfrom09/2010to04/2014.Inclusioncriteria:normalotomicroscopy,hearingthresholds25dBnHLfrom250to4000Hz,normaltympanogram,nosymptomsofMDaccordingtotheAAO-HNS1995criteriaandGibson'sscore<7.Weexcludedsubjectswithdizziness,auralfullnessorothersymptomsofendolymphatichydrops.Thefollowingparameterswereanalyzed:SP/APamplituderatio,SP/AParearatioandthedifferencebetweenAPlatencywithrarefactionandcondensationstimuli.Results:Therewasnosignificantdifferencebetweenrightandleftears(Intraclasscorrelationcoefficient<0.6).SP/APamplituderatiovariedbetween0.084and0.356andSP/AParearatiobetween0.837and1.671(percentiles5and95).TheAPlatencydifferencetorarefactionandcondensationclickswasbetween0.0and0.333ms.Conclusion:NormativedataforTMECochGparameterswereestablishedin100normalhearingsubjectswithoutMD.Thesedatacanbeusedtodistinguishnormalfrompathologicalfindingsandinfollow-upofMDpatients.
简介:Anewthulium-dopedyttrium-aluminium-garnet(YAG)crystalwithvariedconcentrationsofTmwasgrownbyAnhuiInstituteofOpticsandFineMechan-ics,AcademiaSinica.Owingtoitssuperadvantagesofawiderangeoffrequenciesandhighefficience,thegarnetisconsideredtobeaneffectivetunableinfraredlasercrystalandmeetstherequirementsofcoherent
简介:WereportamonolithicTm:YLFmicrolaserinthisLetter.Inordertoimprovetherelaxationoscillationofthelaser,bothendsofthecrystalarecoated,makingtheTm:YLFcrystalitselfaresonantcavity.Themicrolaserispumpedbya792nmlaserdiodeoperatedinthecontinuouswave(CW)mode.Weobtainmaximumoutputpowersof7.78and10.4Watthetotalincidentpowerof43.6Wwithfocuslensesof37.5and40mm,respectively,correspondingtotheslopeefficienciesof25.6%and40.0%andtheoptical–opticalconversionefficienciesof17.8%and23.8%.Itisclearthattheamplitudeoftherelaxationoscillationissmallerandthebeamqualityisbetterwiththefocuslengthof37.5mm;however,thelaserwiththefocuslengthof40mmproducesahigheroutputpowerandamorestablewavelengthcenteringat1878.44nm.