简介：AbstractGastric cancer (GC) is a common malignancy and is the third leading cause of cancer-related death. At present, there is no simple and effective screening method for early-stage GC, and the treatment results and prognosis are poor. With the continuous improvement of molecular biology techniques, research on circular RNA (circRNA) has gradually expanded over time. Much data supports the role of circRNA in tumorigenesis. Moreover, due to its structural specificity and biological stability, circRNA is anticipated to be a potential biomarker for tumor diagnosis. Studies have confirmed that circRNA can participate in the proliferation, invasion, metastasis, and apoptosis of GC. These findings will lead to novel directions for the diagnosis and treatment of GC. This article reviews the structure and function of circRNA, summarizes the current studies on circRNA, and discusses the potential diagnostic value of circRNA in GC.

简介：Objective:ThepresentstudyaimedtoinvestigatecircularRNA(circRNA)expressioninuvealmelanoma(UM).Methods:First,weusedmicroarraytocomparetheexpressionprofilesofcircRNAinfiveUMsamplesandfivenormaluveatissues.Next,bioinformaticsanalyses,includinggeneontology(GO)analysisandpathwayanalysis,wereappliedtostudythesedifferentiallyexpressedcircRNAstopredictpathogenicpathwaysthatmaybeinvolved.Quantitativereal-timepolymerasechainreaction(qRT-PCR)in20UMsamplesand20normaluveasampleswasusedtoconfirmthecircRNAexpressionprofilesobtainedfromthemicroarraydata.Finally,weanalyzedtheinteractionbetweenvalidatedcircRNAsandtheirpotentialcancer-associatedmiRNAtargets.Results:Intotal,50,579circRNAs[foldchange(FC)≥2.0;P<0.05],including20,654up-regulatedand29,925down-regulatedcircRNAs,wereidentifiedasdifferentiallyexpressedbetweenUMtissuesandnormaluveatissues.WeusedqRT-PCRtoverifysevendysregulatedcircRNAsindicatedbythemicroarraydata,includinghsacirc0119873,hsacirc0128533,hsacirc0047924,hsacirc0103232,hsa-circRNA10628-6,hsacirc0032148andhsacirc0133460,whichmaybepromisingcandidatestostudyfuturemolecularmechanisms.Conclusions:Thisstudyexplored,forthefirsttime,theabnormalexpressionofcircRNAsinUManddescribedtheexpressionprofileofcircRNAs,providinganewpotentialtargetforthemechanismofUMandfuturetreatmentofUM.

简介：AbstractBackground:Previous studies have demonstrated that various circular RNAs are involved in the malignant proliferation of cancers, such as liver cancer, lung cancer, breast cancer, and others. The potential role of circular RNAs in glioblastoma, however, is still uncertain. In this study, we aimed to study the potential role of hsa_circ _01844 in glioblastoma.Methods:Using reverse transcription-polymerase chain reaction (RT-PCR) method, hsa_circ_01844 expression was measured in five glioblastoma samples and five normal brain samples. To evaluate the potential function of hsa_circ_01844 in glioblastoma, hsa_circ_01844 was overexpressed in glioblastoma cell lines (U251 and U87 cells). Using these two cell lines, in vitro experiments including the flow cytometry assay, 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazolium bromide assay, Transwell assay, and cell apoptosis assay were performed to investigate the role of hsa_circ_01844 in glioblastoma. Student t test and one-way analysis of variance were used for statistical analysis.Results:The expression of circular RNA hsa_circ_01844 was lower in glioblastoma tissues when compared with the normal brain tissues by RT-PCR method (0.034 ± 0.036 vs. 1.630 ± 0.891, P < 0.001). Using two glioblastoma cell lines, we found that overexpression of hsa_circ_01844 in glioblastoma cells suppressed their proliferation, colony formation, migration, and increased the apoptotic rate compared with empty vector group and blank control group (all P < 0.05).Conclusion:Hsa_circ_01844 shows decreased expression in glioblastoma and its overexpression induces apoptosis and inhibits proliferation, migration, and invasion of glioblastoma cells.

简介：AnanalyticalsolutionforscatteringofincidentSHwavesbyacircular-archillwithaconcentriccirculartunnelwasderivedbyFourier-Besselseriesexpansionandauxiliaryfunctionstechnique.Thesolutionisreducedtosolvingasetofinfinitelinearalgebraicequationsfinally.Theaccuraciesofthenumericalresultsarecheckedbytheresidualerrorsofboundaryconditionswiththetruncationorderincreasing.Thenumericalresultsshowthattheexistenceanddimensionofthetunnelhavegreateffectonmotionofthegroundsurfacenearbyanddynamicstressconcentrationofthetunnel.

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简介：AsanewlydiscoveredtypeofRNA,circularRNAs(circRNAs)arewidespreadthroughouttheeukaryoticgenome.TheexpressionofcircRNAsisregulatedbybothcis-elementsandtrans-factors,andtheexpressionpatternofcircRNAsiscelltype-anddiseasespecific.Similartoothertypesofnon-codingRNAs,functionsofcircRNAsarealsoversatile.CircRNAshavebeenreportedpreviouslytofunctionasmicroRNA(miRNA)sponges,proteinsponges,codingRNAsorscaffoldsforproteincomplexes.Recently,severalcircRNAshavebeenreportedtoplayimportantrolesinhumanmalignancies,includingglioma.Here,wereviewedseveralreportsrelatedtocircRNAsandglioma,aswellasthepotentialdiagnosticandtherapeuticapplicationsofcircRNAsinbraincancer.Ingeneral,somecircRNAs,suchascircSMARCA5andcircCFH,arefoundtobeexpressedinagliomaspecificpattern,thesecircRNAsmaybeusedastumorbiomarkers.Inaddition,somecircRNAshavebeenfoundtoplayoncogenicrolesinglioma(e.g.,circNFIXandcircNT5E),whereasothershavebeenreportedtofunctionastumorsuppressors(e.g.,circFBXW7andcircSHPRH).Furthermore,circRNAisagoodtoolforproteinexpressionbecauseofitshigherstabilitycomparedtolinearRNAs.Thus,circRNAsmayalsobeanidealchoiceforgene/proteindeliveryinfuturebraincancertherapies.TherearesomechallengesincircRNAresearchingliomaandotherdiseases.ResearchrelatedtocircRNAsingliomaiscomparativelynewandmanymysteriesremaintobesolved.

简介：Circulareconomy(CE)hasbeenputforwardasanimportantenvironmentalandresourcestrategyinChina.Aimingatthehighutilizationrateofresourcesandreductionofpollutants,CEmeanstorealizeashiftoffundamentalparadigm.Withthemodeofproductionandconsumptionfromlineartorecyclingmodel,thepromotionrequirestransdisciplinaryresearcheswhichintegratetechnological,ecological,social-culturalandothersciences.Thepresentstudyfocusesontheimplementationofcirculareconomyfromaninstitutionalperspective.Institutionactsasacrucialfactorbyprovidingincentivesfortechnicalinnovation,leadinginvestmentorientationanddeterminingpolicyeffectiveness,etc.Thispapermainlydiscussesabout:firstly,thefeatureofinstitution,institutionalchangesandinstitutionalinnovationisarticulated,togetherwitheco-industrialparkstrategy,extendedproducer’sresponsibilityanddematerializationprincipleasinnovativeinstitutionalarrangements;secondly,aspolicyplaysgreatroleoninstitutionalchangingprocess,themechanismofpolicyimplementationisneededtoberelated;asaresult,coevolutionofinstitutionsandpoliciesisthuspresented;atlast,apilotattemptismadetofindoutsomeoperationalavenuesinaccomplishmentofCEthroughboththeoreticalandpracticalmethodology,specialresolutionsareputforwardaftersomeprojectingdifficultiesanddilem-masinChinaaredescribed.

简介：Thispaperproposesacircularthresholdquantumsecretsharing(TQSS)schemewithpolarizedsinglephotons.Apolarizedsinglephotonsequencerunscircularlyamonganytormoreofnpartiesandanytormoreofnpartiescanreconstructthesecretkeywhentheycollaborate.Itshowsthatentanglementisnotnecessaryforquantumsecretsharing.Moreover,thetheoreticefficiencyisimprovedtoapproach100%asthesinglephotonscarryingthesecretkeyaredeterministicallyforwardedamonganytormoreofnparties,andeachphotoncancarryonebitofinformationwithoutquantumstorage.Thisprotocolisfeasiblewithcurrenttechnology.

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简介：Itisdifficulttorealizethetransformationfromtradi-tionaleconomyindustrialsystemtocirculareconomyindustrialsystem.Regardingprimaryrawmaterialsastheindicators,theindustrialsystemhasbeenspecifiedaccordingtothedivergenceamongtheindicatorsandthecircularutilizationmodes.Incom-parisonwiththeassociationamongindustrialsystems,therela-tionshipamongindustrialsub-systemsisnamedasindustrialcross-linkinginthispaper.Theindustrialsystemwhichcouldcompletelyutilizeandrecycletheindicatorsshouldbeincreasedandstrengthened,andthecirculareconomyindustrialsystemwithcompleteindustrialassociationandindustrialcross-linkingshouldalsobeconstructed.Takingthedevelopmentofcircularagricul-turalsystembasingonthetraditionalagriculturalsystemasanexample,thetraditionalagriculturalproductsareregardedastheindicatorswhichhavebeendividedintofoodstuffandcropstrawswhichareusedtoproducefoodandarticlesforuse,likefertilizer,energyandpapersetc.Thewaytoconstructthecircularagricul-turalindustrialsystemistoincreasetheindustrialsystemsthatcouldutilizetheproductsgeneratedfromcropstraws,fecesandothercastoffsandtransformthewastewaterandothertrucksintoenvironmentalfriendlyproducts.Ithasalsobeenpointedoutthattheconstructionofcirculareconomyindustrialsystemiscondu-civetothefoundationofcircularindustrialeconomicsandtheestablishmentoftheconstructionlayoutofcirculareconomyandtheapplicationschemes.Suggestionstothetheoreticalandprac-ticalworkofthenextstephavealsobeenbroughtforwardinthispaper.

简介：Ecologicaleconomicsandsustainabledevelopmenteconomicsarethebasictheoriestoresearchoncirculareconomy.Throughthesystemicallyresearchontherelationshipofthethreeabove,thispaperthinksthatthereuseandrecycleofcirculareconomyisawaythatthestallismendedafterasheepislost.Althoughthereductiontechnicallycontrolstheproductionprocess,itcannotsolvethewastecausedbyblindproductionandexcesscompetition.Wehaveexperiencedvarietyobstacleswhenimplementingthecirculareconomy,whosemainreasonistheconflictbetweentheindividualrationandthesocialration.Therefore,onlywhentheindividualrationandsocialrationinclinetoconformity,thecooperatingNashequilibriumwillbeappeared.Inordertorealizetheharmonyofecology,economyandsociety,wehavetoexploreeffectiveevaluationtheory.Thispapercitesthe'fiveflowsofwealthoperationtheory'fromprofessorMaChuandongtosearchoperationmechanismofcirculareconomy,makesclearthedevelopingthoughtsofcirculareconomybasedontherealities,andbringsforwardsomecountermeasurestodevelopcirculareconomybasedontheabovetheoreticalanalysis.

简介：Theanalysisofthedataofmodeltestsoftwolargedeepwharvesandmonographicexperimentalstudiesshowthattwoaspectsaretobeimprovedsoastopredictthewaveupliftforcesonthebottomofacircularcylinder.Thefirstaspectistheupliftpressuredistributiononthebottom,andthesecondisthecorrectdeterminationofthephaseformaximumhorizontalwaveforces.Thesecondproblemhasbeensolved.Synthesizingtheresultsoftheoreticalanalysisandexperiments,wesuggestadiagramforthedeterminationofthephasewhenthemaximumhorizontalwaveforceappears.Onthebasis-efthediagramthesimultaneouswaveupliftforcescanbeobtainedforthestructuralstabilityanalysis.

简介：ＮＵＭＥＲＩＣＡＬ　ＳＩＭＵＬＡＴＩＯＮ　ＯＦ　ＤＩＳＣＯＮＴＩＮＵＯＵＳ　ＦＬＯＷ　ＩＮ　ＣＩＲＣＵＬＡＲ　ＣＯＮＤＵＩＴＳＮＵＭＥＲＩＣＡＬＳＩＭＵＬＡＴＩＯＮＯＦＤＩＳＣＯＮＴＩＮＵＯＵＳＦＬＯＷＩＮＣＩＲＣＵＬＡＲＣＯＮＤＵＩＴＳ￥ＭａｏＺｅ...

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简介：ThesedimentationofcircularparticlesinaverticalchannelfilledwithOldroyd-BfluidwasstudiedbyanimprovedDistributedLagrangeMultiplier/fictitiousdomain(DLM)method.Thesedimentingbehaviorsoftwoparticlesarepresentedfirstly,whichshowsthat,whentheparticlesaredroppedinaviscoealsticfluid,thestableconfigurationistheonewheretheparticlesarealignedparalleltotheflowdirectionwhentheMachnumberMislessthan1andtheelasticitynumberEisgreaterthan1.ThisagreeswellwiththeknownexperimentalinRef.[1]andsimulationresultsinRef.[2].Oursimulationsalsoshowthat,asinNewtonianfluid,thesedimentationoftheparticleswillbeacceleratedduetotheinteractionbetweenparticlesinaviscoealsticfluid.

简介：AbstractCircular RNAs (circRNAs) constitute a novel class of endogenous noncoding RNAs characterized by a covalently closed structure and involved in multiple biological processes. The main biological functions and properties of circRNAs can be defined by five features: a "sponging" effect on other RNA species, post-transcriptional regulation, rolling circle translation, generation of pseudogenes, and splicing interference. Although circRNAs were first detected decades ago, the role of circRNAs and the mechanisms underlying their actions remain incompletely characterized. Recently, circRNAs were reported to play indispensable roles in regulating metabolic and signal transduction events controlling the proliferation, migration, and survival of cells. Importantly, many studies demonstrated that dysregulated circRNA expression is associated with the development of multiple diseases, including cancer. In this review, we summarize current knowledge on the roles and mechanisms of circRNAs in cancer and discuss their functions as oncogenes or tumor suppressors in different tumor types.

简介：OnAugust8,2005,Hohhotwasawardedthetitleof'ChineseDairyCapital'.NowdairyindustryisoneofthepillarindustriesinHohhot,withstrongdrivingeffecttothedevelopmentofsocialeconomy.However,thesustainabledevelopmentofdairyindustryinHohhotisthreatenedbyrapidscaleexpansionandrestrictionofenvi-ronmentalsupportingcapacity.Inaccordwiththeideasandrequirementsofthecirculareconomytheory,thispaperanalyzesdairyindustrypatternfromtwoaspectsandestablishestheindustrysystem.Thedairyindustrymainlyconsistsofcowbreedinganddairyprocess.Thecirculareconomymustsetaboutfromthetwoaspects.Forthemostpart,dairyprocessingshouldstartfromthetwomostkeylinks,namelypackingandwaterusing.

简介：Theinfluenceofcircularapertureontheintensityofhigh-orderharmonicgeneration(HHG)withintensefemtosecondlaserpulsewasstudiedbothexperimentallyandtheoretically.TheintensityvarietyofHHGwiththediameterofcircularaperturewasobservedinpulsedArgas.TheresultwasdiscussedandinterpretedintermsofthetheoryofHankeltransform.ItisfoundthatusingtheGaussianbeamtruncatedbyanaperturecouldenhancetheconversionefficiencyofHHGatcertainconditions.

简介：Wehaveobservedthecirculardichroismsignalofdilutegrapheneoxide（GO）,thensystematicallyinvestigatedthechiralityofGOandestablishedaprobablechiralunitmodel,ThisstudymayopenupanewfieldforunderstandingthestructureofGOandlaythefoundationforfabricationofGO-basedmaterials.

简介：Thepapertriestoexplorecirculareconomyfromtheviewpointofthesystemtheory.Circulareconomyisakindofcomplicatedeconomicactivity,anditisawhollynewecotypeeconomyproposedbyWesterncountriesaftertheyhadsummedupmanyexperiencesandlessonsfromtraditionaleconomy.Itisanentiretyandhasmanylayers.Itkeepsanopenanddynamicbalance.Becausethesystemtheoryisthetheoreticalfoundationofcirculareconomy,weshouldsystemicallyanalyzeandstudycirculareconomyfromthemacroscopicview,correctlygraspitsoperationallaws,improveitsservicefunctions,andrealizehumanbeings'sustainabledevelopment.Thepaperintroducesthecontentandgeneralcharacteristicsofthesystemtheoryandtheideaofcirculareconomy.Thenitanalyzescirculareconomybasedonthesystemtheory.Thepaperconcludesthattheintegrationofcirculareconomyandthesystemtheorycanpromotethefunctionsofcirculareconomy.